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Journal of Dental Research
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CONCISE REVIEW Biological: Interleukin 1 Signal Transduction— Current Concepts and Relevance to Periodontitis

J.A. Boch

Department of Periodontology, Harvard School of Dental Medicine, Boston, MA 02115, New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, jboch{at}caregroup.harvard.edu

N. Wara-aswapati

Department of Periodontology, Faculty of Dentistry, Khon Kaen University, Thailand

P.E. Auron

Department of Medicine, Harvard Medical School, Boston, MA, New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115

This review examines a well-characterized factor, interleukin 1 (IL-1), that has recently received considerable attention. A level of understanding is emerging that goes beyond simple recognition that IL-1 plays a role in disease, and begins to explain the molecular mechanisms of function. This review summarizes some current information on the importance of IL-1 in periodontitis as well as the signal transduction of IL-1, from binding to its cell-surface receptors, to the activation of cytoplasmic mediators and transcription factors responsible for the induction of target genes. The effect of IL-1 signal transduction is ultimately the activation and repression of specific transcription factors that regulate genes responsible for cellular activities. As additional steps of signal transduction become better-characterized, these insights may facilitate the development of improved therapeutic approaches for controlling inflammation and connective tissue destruction in a variety of diseases.

Key Words: IL-1 • interleukin 1 • signal transduction • periodontitis

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Journal of Dental Research, Vol. 80, No. 2, 400-407 (2001)
DOI: 10.1177/00220345010800020101
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