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Age, Dental Infections, and Coronary Heart Disease
K.J. Mattila
Dept. of Medicine, Division of Cardiology and Division of Infectious Diseases, Helsinki University Central Hospital, Haartmaninkatu 4, 00290, Helsinki, Finland
S. Asikainen
; Depts. of Periodontology and Oral Radiology, Institute of Dentistry, University of Helsinki
J. Wolf
; Depts. of Periodontology and Oral Radiology, Institute of Dentistry, University of Helsinki
H. Jousimies-Somer
Anaerobic Reference Laboratory, National Public Health Institute, Helsinki, Finland
V. Valtonen
Dept. of Medicine, Division of Cardiology and Division of Infectious Diseases, Helsinki University Central Hospital, Haartmaninkatu 4, 00290, Helsinki, Finland
M. Nieminen
Dept. of Medicine, Division of Cardiology and Division of Infectious Diseases, Helsinki University Central Hospital, Haartmaninkatu 4, 00290, Helsinki, Finland
Epidemiological and intervention studies have suggested that infections are risk factors for coronary heart disease (CHD). Dental infections have appeared as cardiovascular risk factors in cross-sectional and in follow-up studies, and the association has been independent of the "classic" coronary risk factors. This case-control study aimed at detailed assessment of the dental pathology found in various CHD categories (including elderly patients). Altogether, 85 patients with proven coronary heart disease and 53 random controls, matched for sex, age, geographic area, and socio-economic status, were compared with regard to dental status, assessed blindly with four separate scores, and to the "classic" coronary risk factors (seven of the controls had CHD, and they were not included in the analyses). The dental indices were higher among CHD patients than in the controls, but, contrary to previous studies, the differences were not significant (between the CHD patients and their matched controls or among the different CHD categories). This result could not be explained by potential confounding factors. The participants in the present study were older and had more often undergone recent dental treatment in comparison with subjects in our earlier studies. Age correlated with the severity of dental infections only in the random controls but not in the coronary patients who, although young, already had high dental scores. We believe that the higher age of the participants in the present study is the most likely reason for the results. Other possible explanations include an age-related selection bias among older CHD patients, and the fact that those participating in studies like this may have better general health and thus also less severe dental infections. Thus, the role of dental infections as a coronary risk factor varies according to the characteristics of the population studied.
Key Words: dental infections • periodontitis • coronary heart disease.
REFERENCES
- Armitage P., Berry G. (1994). Intraclass correlation. In: Statistical methods in medical research. 3rd ed. London: Blackwell Science Ltd, pp. 273-276.
- Asikainen S., Jousimies-Somer H., Kanervo A., Saxen L. (1986). Actinobacillus actinomycetemcomitans and clinical periodontal status in Finnish juvenile periodontitis patients. J Periodontol 57:91-93.[Medline]
[Order article via Infotrieve]
- Beck J., Garcia R., Heiss G., Vokonas PS, Offenbacher S. (1996). Periodontal disease and cardiovascular disease. J Periodontol 67(Suppl 10):1123-1137.[Medline]
[Order article via Infotrieve]
- DeStefano F., Anda RF, Kahn HS, Williamson DF, Russell CM (1993). Dental disease and risk of coronary heart disease and mortality. BMJ 306:688-691.[Abstract/Free Full Text]
- Funk JL, Feingold KR, Moser AH, Grunfeld C. (1993). Lipopolysaccharide stimulation of RAW 264.7 macrophages induces lipid accumulation and foam cell formation. Atherosclerosis 98:67-82.[CrossRef][Medline]
[Order article via Infotrieve]
- Genco R., Chadda S., Grossi S., Dunford R., Taylor G., Knowler W., et al. (1997). Periodontal disease is a predictor of cardiovascular disease in a native American population (abstract). J Dent Res 76(Spec Iss):408.
- Gupta S., Leatham EW, Carrington D., Mendall MA, Kaski JC, Camm AJ ( 1997). Elevated Chlamydia pneumoniae antibodies, cardiovascular events, and azithromycin in male survivors of myocardial infarction. Circulation 96:404-407.[Abstract/Free Full Text]
- Gurfinkel E., Bozovich G., Beck E., Testa E., Livellara B., Mautner B. (1999). Treatment with antibiotic roxithromycin in patients with acute non-Q-wave coronary syndromes. The final report of the ROXIS study. Eur Heart J 20:121-127.[Abstract/Free Full Text]
- Joshipura KJ, Rimm EB, Douglas CW, Trichopoulos D., Ascherto A., Willet CW (1996). Poor oral health and coronary heart disease. J Dent Res 75:1631-1636.
- Lowe Gdo, Kweider M., Murray GD, Kinane D., McGowan DA (1992). Fibrinogen and dental disease-a coronary risk factor. In: Fibrinogen-a "new" cardiovascular risk factor. Ernst E, Koenig W, Lowe GDO, Meade TW, editors. Vienna: Blackwell-MZV, pp. 457-472.
- Machin D., Campbell MJ (1987). Comparing two means. In: Statistical tables for the design of clinical trials. Oxford, UK: Blackwell Scientific Publications, pp. 79-89.
- Mattila KJ (1990). Infections and coronary heart disease (dissertation). Helsinki: University of Helsinki, Finland.
- Mattila KJ, Nieminen MS, Valtonen VV, Rasi VP, Kesaniemi YA, Syrjala SL, et al. (1989a). Association between dental health and acute myocardial infarction. BMJ 298:779-781.[Abstract/Free Full Text]
- Mattila K., Rasi V., Nieminen M., Valtonen V., Kesaniemi A., Syrjala S., et al. (1989b). Von Willebrand factor antigen and dental infections. Thromb Res 56:325-329.[CrossRef][Medline]
[Order article via Infotrieve]
- Mattila KJ, Valle MS, Valtonen W., Nieminen MS, Hietaniemi KL (1993). Dental infections and coronary atherosclerosis. Atherosclerosis 103:205-211.[Medline]
[Order article via Infotrieve]
- Mattila KJ, Valtonen W., Nieminen MS, Huttunen JK (1995). Dental infection and the risk of new coronary events: prospective study of patients with documented coronary artery disease. Clin Infect Dis 20:588-592.[Medline]
[Order article via Infotrieve]
- Mattila KJ, Valtonen W., Nieminen MS, Asikainen S. (1998). Role of infection as a risk factor for atherosclerosis, myocardial infarction, and stroke. Clin Infect Dis 26:719-734.[Medline]
[Order article via Infotrieve]
- Mattila KJ. Unpublished observations.
- Nyman A., Lindhe J. (1989). Examination of patients with periodontal disease. In: Textbook of clinical periodontology. 2nd ed. Lindhe J, editor. Copenhagen: Munksgaard, pp. 310-322.
- Paunio K., Tiekso J., Impivaara 0, Maki J. ( 1993). Missing teeth and ischaemic heart disease in men aged 45-64 years. Eur Heart J 14(Suppl K):54-56.[Medline]
[Order article via Infotrieve]
- Roivainen M., Alfthan G., Jousilahti P., Kimpimaki M., Hovi T., Tuomilehto J. (1998). Enterovirus infections as a possible risk factor for myocardial infarction. Circulation 98:2534-2537.[Abstract/Free Full Text]
- Suffredini AF, Harpel PC, Parrillo JE (1989). Promotion and subsequent inhibition of plasminogen activation after administration of intravenous endotoxin to normal subjects. N Engl J Med 320:1165-1172.[Abstract]
- Syrjanen J., Valtonen VV, livanainen M., Kaste M., Huttunen JK (1988). Preceding infection as an important risk factor for ischaemic brain infarction in young and middle aged patients. Br Med J 296:1156-1160.[Abstract/Free Full Text]
- Thompson SG, Kienast J., Pyke SD, Haverkate F., van de Loo JC (1995). Hemostatic factors and the risk of myocardial infarction or sudden death in patients with angina pectoris. European Concerted Action on Thrombosis and Disabilities Angina Pectoris Study Group. N Engl J Med 332:635-641.[Abstract/Free Full Text]
Journal of Dental Research, Vol. 79, No. 2,
756-760 (2000)
DOI: 10.1177/00220345000790020901
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