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Evidence of Chemical Bonding at Biomaterial-Hard Tissue Interfaces

Department of Biomaterials Science, Hiroshima University Faculty of Dentistry, 1-2-3 Kasumi, Minami-Ku, Hiroshima 734-8553, Japan;

B. Van Meerbeek

BIOMAT-Department of Operative Dentistry and Dental Materials, School of Dentistry, Oral Pathology and Maxillo-Facial Surgery, Catholic University of Leuven, Kapucijnenvoer 7, B-3000, Leuven, Belgium

Y. Nakayama

National Space Development Agency of Japan (NASDA), Sengen 2-1-1, Tsukuba, lbaraki 305-8505, Japan

J. Snauwaert

Laboratory for Chemical and Biological Dynamics, Department of Chemistry, Catholic University of Leuven, Celestijnenlaan 200D, B-3001 Heverlee, Belgium

L. Hellemans

Laboratory for Chemical and Biological Dynamics, Department of Chemistry, Catholic University of Leuven, Celestijnenlaan 200D, B-3001 Heverlee, Belgium

P. Lambrechts

BIOMAT-Department of Operative Dentistry and Dental Materials, School of Dentistry, Oral Pathology and Maxillo-Facial Surgery, Catholic University of Leuven, Kapucijnenvoer 7, B-3000, Leuven, Belgium

G. Vanherle

BIOMAT-Department of Operative Dentistry and Dental Materials, School of Dentistry, Oral Pathology and Maxillo-Facial Surgery, Catholic University of Leuven, Kapucijnenvoer 7, B-3000, Leuven, Belgium

K. Wakasa

Department of Biomaterials Science, Hiroshima University Faculty of Dentistry, 1-2-3 Kasumi, Minami-Ku, Hiroshima 734-8553, Japan;

For many years, glass-polyalkenoate cements have been described as possessing the unique properties of self-adherence to human hard tissues, such as bones or teeth. However, direct experimental evidence to prove the existence of chemical bonding has not been advanced. X-ray Photoelectron Spectroscopy (XPS) was used to analyze the chemical interaction of a synthesized polyalkenoic acid with enamel and synthetic hydroxyapatite. For both enamel and hydroxyapatite, the peak representing the carboxyl groups of the polyalkenoic acid was detected to have significantly shifted to a lower binding energy. De-convolution of this shifted peak disclosed two components with a peak representing unreacted carboxyl groups and a peak suggesting chemical bonding to hydroxyapatite. On average, 67.5% of the carboxyl groups of the polyalkenoic acid were measured to have bonded to hydroxyapatite. XPS of hydroxyapatite also disclosed its surface to be enriched in calcium and decreased in phosphorus, indicating that phosphorus was extracted at a relatively higher rate than calcium. Analysis of these data supports the mechanism in which carboxylic groups replace phosphate ions (PO ₄^3-) of the substrate and make ionic bonds with calcium ions of hydroxyapatite. It is concluded that an ultrathin layer of a polyalkenoic acid can be prepared on a hydroxyapatite-based substrate by careful removal of non-bonded molecules. With this specimen-processing method, XPS not only provided direct evidence of chemical bonding, but also enabled us to quantify the percentages of functional groups of the polyalkenoic acids that bonded to calcium of hydroxyapatite.

Key Words: polyalkenoic acid • enamel • hydroxyapatite • chemical bonding • interface.

REFERENCES

• Akinmade AO, Nicholson JW (1993). Glass-ionomer cements as adhesives. Part I: Fundamental aspects and their clinical relevance. J Mater Sci Mater Med 4:93-101.
• Briggs D., Seah MP ( 1990). Practical surface analysis. Vol. 1. Auger and x-ray photoelectron spectroscopy. 2nd ed. New York: John Wiley & Sons.
• Degrange M., Roulet JF (1997). Minimally invasive restorations with bonding. Chicago: Quintessence Publishing.
• Esker AR, Mengel C., Wegner G. (1998). Ultrathin films of a polyelectrolyte with layered architecture. Science 280:892-895.[Medline] [Order article via Infotrieve]
• Gladys S., Van Meerbeek B., Braem M., Lambrechts P., Vanherle G. (1997). Comparative physico-mechanical characterization of new hybrid restorative materials with conventional glass-ionomer and resin composite restorative materials. J Dent Res 76:883-894.
• Kent BE, Lewis BG, Wilson AD (1979). Glass ionomer cement formulations: I. The preparation of novel fluoroaluminosilicate glasses high in fluorine. J Dent Res 58:1607-1619.
• Knight J. (1998). Tight fit. Joint implants could last decades if disguised as bone. New Sci 158(2140):15.
• Lin A., McIntyre NS, Davidson RD (1992). Studies on the adhesion of glass-ionomer cements to dentin. J Dent Res 71:1836-1841.
• Nakabayashi N., Pashley DH (1998). Hybridization of dental hard tissues. Tokyo: Quintessence Publishing.
• Peppas NA, Langer R. (1994). New challenges in biomaterials. Science 263:1715-1720.[Abstract/Free Full Text]
• Smith DC (1968). A new dental cement. Br Dent J 124:381-384.[Medline] [Order article via Infotrieve]
• Titley KC, Smith DC, Chernecky R. (1996). SEM observations of the reactions of the components of a light-activated glass polyalkenoate (ionomer) cement on bovine dentine. J Dent 24:411-416.[Medline] [Order article via Infotrieve]
• Vaidyanathan J., Vaidyanathan TK, Schulman A. (1984). Demineralization and ion binding action of polycarboxylate cement liquid on human dental enamel. J Biomed Mater Res 18:871-880.[Medline] [Order article via Infotrieve]
• Wilson AD, Kent BE ( 1972). A new translucent cement for dentistry. The glass ionomer cement. Br Dent J 132:133-135.[CrossRef][Medline] [Order article via Infotrieve]
• Wilson AD, Prosser HJ, Powis DM (1983). Mechanism of adhesion of polyelectrolyte cements to hydroxyapatite. J Dent Res 62:590-592.
• Wood D., Hill R. ( 1991). Glass ceramic approach to controlling the properties of a glass-ionomer bone cement. Biomaterials 12:164-170.
• Zasadzinski JA, Viswanathan R., Madsen L., Gamaes J., Schwartz DK (1994). Langmuir-Blodgett films. Science 263:1726-1733.[Abstract/Free Full Text]

Journal of Dental Research, Vol. 79, No. 2, 709-714 (2000)
DOI: 10.1177/00220345000790020301


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