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Tony Melcher's Contributions to the Regeneration of the Periodontium

MRC Group in Periodontal Physiology, Faculty of Dentistry, Room 244, 150 College Street, University of Toronto, Toronto, ON, Canada M5S 3E8

The impact of Tony Melcher's scientific work on periodontal regeneration is discussed in light of his interests in cellular domains and bone healing, the physiology of the periodontal ligament, and his development of organ and cell culture methods. Collectively, his scientific accomplishments have pointed us in new directions for approaching periodontal regeneration and have helped to create new research opportunities, many of which were previously unrecognized. Tony's scientific ideas are insightful, numerous, and compelling; his ability to make these ideas come alive and relevant to clinical problems has been a major influence in shaping our current thinking on the biology of the periodontium and on periodontal regeneration.

Key Words: periodontium • bone • cell cultur, • wound healing • periodontal ligament

REFERENCES

• Bellows CG, Melcher AH, Brunette DM (1980). Orientation of calvaria and periodontal ligament cells in vitro by pairs of demineralized dentine particles. J Cell Sci 44:59-73. Bellows CG, Melcher AH, Aubin JE (1981). Contraction and organization of collagen gels by cells cultured from periodontal ligament, gingiva and bone suggest functional differences between cell types. J Cell Sci 50:299-314.
• Bellows CG, MeIcher AH, Bhargava U., Aubin JE (1982). Fibroblasts contracting three-dimensional collagen gels exhibit ullrastructure consistent with either contraction or protein secretion. J Ultrastruct Res 78:178-192.[CrossRef][Medline] [Order article via Infotrieve]
• Birek C., Aubin JE, Bhargava U., Brunette DM, Melcher AH (1982). Dome formation by oral epithelia in vitro. In Vitro 18:382-392.[Medline] [Order article via Infotrieve]
• Boyko GA, Melcher AH, Brunette DM (1981). Formation of new periodontal ligament by periodontal ligament cells implanted in vivo after culture in vitro. A preliminary study of transplanted roots in the dogs. J Periodont Res 16-73-88.[Medline] [Order article via Infotrieve]
• Brunette DM, Melcher AH, Moe HK ( 1976). Culture and origin of epithelium-like and fibroblast-like cells from porcine periodontal ligament explants and cell suspensions. Arch Oral Biol 21:393-400.[CrossRef][Medline] [Order article via Infotrieve]
• Brunette DM, Kanoza RJ, Marinary Y., Chan J., Melcher AH (1977), Interactions between epithelial and fibroblast-like cells in cultures derived from monkey periodontal ligament. J Cell Sci 27:127-140.[Medline] [Order article via Infotrieve]
• Gould Trl, Melcher AH, Brunette DM (1980). Migration and division of periodontal ligament after wounding. J Periodont Res 15:20-42.[CrossRef][Medline] [Order article via Infotrieve]
• Maniatopoulos C., Sodek J., Melcher AH (1988). Bone formation in vitro by stromal cells obtained from bone marrow of young adult rats. Cell Tissue Res 254:317-330.[Medline] [Order article via Infotrieve]
• Melcher AH (1970). Repair of wounds in the periodontium of the rat. Influence of periodontal ligament on osteogenesis. Arch Oral Biol 15:1183-1204.[Medline] [Order article via Infotrieve]
• Melcher AH (1976). On the repair potential of periodontal tissues. J Periodontol 47:256-260.[Medline] [Order article via Infotrieve]
• Melcher AH, Bowen WH, editors (1969). The biology of the periodontium. London: Academic Press.
• Melcher AH, Dreyer CJ (1961). The experimental use of polytetrafluorethylene as an implant material. S Afr J Med Sci 26:125-128.[Medline] [Order article via Infotrieve]
• Melcher AH, Dreyer CJ (1962). Protection of the blood clot in healing circumscribed bone defects. J Bone Joint Surg (Br) 44(B):424-430.
• Melcher AH, Hodges GM (1968). In vitro culture of an organ containing mixed epithelial and connective tissues on a chemically defined medium. Nature (London) 219:301-302.[Medline] [Order article via Infotrieve]
• Melcher AH, Irving JT (1963). The effect of implanting various substances into artificially created circumscribed defects in rat femurs. J Bone Joint Surg (Br) 45(B):162-175.
• Melcher AH, Turnbull RS, Huddleston WJ (1973). In-vitro culture of periodontium of young adult mouse. Arch Oral Biol 18:933-939.[Medline] [Order article via Infotrieve]
• Melcher AH, Holowka S., Pharoah M., Lewin PK (1997). Non-invasive computed tomography and three-dimensional reconstruction of the dentition of a 2,800-year-old Egyptian mummy exhibiting extensive dental disease. Am J Phys Anthropol 103:329-340.[CrossRef][Medline] [Order article via Infotrieve]
• Ogiso B., Hughes FJ, Melcher AH, McCulloch CA (1991). Fibroblasts inhibit mineralised bone nodule formation by rat bone marrow stromal cells in vitro. J Cell Physiol 146:442-450.[CrossRef][Medline] [Order article via Infotrieve]
• Pitaru S., Melcher AH (1987). Orientation of gingival fibroblasts and newly synthesized collagen fibers in vitro. Resemblance to transseptal and dento-gingival fibers. J Periodont Res 18:483-500.
• Yen EH, Sodek J., Melcher AH (1979). The effect of oxygen partial pressure on protein synthesis and collagen hydroylation by mature periodontal tissues maintained in organ cultures. Biochem J 178:605-612.[Medline] [Order article via Infotrieve]

Journal of Dental Research, Vol. 78, No. 7, 1292-1297 (1999)
DOI: 10.1177/00220345990780070201


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by McCulloch, C. A. Search for Related Content PubMed PubMed Citation Articles by McCulloch, C. A. Social Bookmarking                         What's this?