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Journal of Dental Research
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Occlusal Disharmonies Modulate Central Catecholaminergic Activity in the Rat

M.P. Areso

Department of Pharmacology, Faculty of Medicine and Odontology, University of the Basque Country, Apdo. 699-48080, Bilbao, Leioa, Bizkaia, Spain

M.T. Giralt

Department of Pharmacology, Faculty of Medicine and Odontology, University of the Basque Country, Apdo. 699-48080, Bilbao, Leioa, Bizkaia, Spain

B. Sainz

Department of Stomatology, Faculty of Medicine and Odontology, University of the Basque Country, Apdo. 699-48080, Bilbao, Leioa, Bizkaia, Spain

M. Prieto

Department of Pharmacology, Faculty of Medicine and Odontology, University of the Basque Country, Apdo. 699-48080, Bilbao, Leioa, Bizkaia, Spain

P. Garcia-Vallejo

Department of Stomatology, Faculty of Medicine and Odontology, University of the Basque Country, Apdo. 699-48080, Bilbao, Leioa, Bizkaia, Spain

F.M. Gómez

Department of Stomatology, Faculty of Medicine and Odontology, University of the Basque Country, Apdo. 699-48080, Bilbao, Leioa, Bizkaia, Spain

Occlusal disharmonies have classically been thought to be involved in the etiopathogenesis of bruxism, as have, more recently, alterations in central neurotransmission, particularly dopaminergic neurotransmission. However, the connection between these two factors has still not been established. In this study, we assessed the effects of diverse occlusal disharmonies, maintained for either 1 day or 14 days, on neurochemical indices of dopaminergic and noradrenergic activity in the striatum, frontal cortex, and hypothalamus of the rat. The in vivo activity of tyrosine hydroxylase, determined as the accumulation of 3,4-dihydroxyphenylalanine (DOPA), 30 min after the administration of 3-hydroxybenzylhydrazine, a DOPA decarboxylase inhibitor, and dopamine and noradrenaline contents were quantified by high-performance liquid chromatography with electrochemical detection. The wearing of an acrylic cap on both lower incisors for 1 day induced a significant increase in DOPA accumulation in the regions analyzed, with parallel increases in dopamine levels in the hypothalamus and dopamine and noradrenaline in the frontal cortex. After the cap was maintained for 14 days, DOPA accumulation tended to return to control values, except in the left striatum, thereby causing an imbalance between hemispheres. In contrast, 1 or 14 days after the lower left and the upper right incisors were cut, less pronounced changes in catecholaminergic neurotransmission were found in the brain areas studied. Moreover, the cutting of one lower incisor did not modify either DOPA accumulation or dopamine and noradrenaline contents in the striatum or hypothalamus. These results provide experimental evidence of a modulation of central catecholaminergic neurotransmission by occlusal disharmonies, being dependent on the nature of the incisal alteration and on the time during which it was maintained.

Key Words: occlusal disharmonies • DOPA accumulation • central catecholaminergic neurotransmission • bruxism

REFERENCES

  • Abercrombie ED, Keefe KA, DiFrischia DS, Zigmond MJ (1989). Differential effect of stress on in vivo dopamine release in striatum, nucleus accumbens, and medial frontal cortex. J Neurochem 52:1655-1658.[Medline] [Order article via Infotrieve]
  • Adams F., Schwarting RK, Boix F., Huston JP (1991). Lateralized changes in behavior and striatal dopamine release following unilateral tactile stimulation of the perioral region: a microdialysis study. Brain Res 553:318-322.[Medline] [Order article via Infotrieve]
  • Amir I., Hermesh H., Gavish A. (1997). Bruxism secondary to antipsychptic drug exposure: a positive response to propranolol. Clin Neuropharmacol 20:86-89.[Medline] [Order article via Infotrieve]
  • Anisman H., Zacharko RM (1990). Multiple neurochemical and behavioral consequences of stressors: implications for depression. Pharmacol Ther 46:119-136.[CrossRef][Medline] [Order article via Infotrieve]
  • Ashcroft GW, Eccleston D., Waddell JL (1965). Recognition of amphetamine addicts (letter). Br Med J 1:57.[Free Full Text]
  • Baldessarini RJ (1996). Drugs and the treatment of psychiatric disorders. In: Goodman & Gilman's The pharmacological basis of therapeutics. Hardman JG, Limbird LE, editors. New York: McGraw-Hill, pp. 399-459.
  • Bleuler E. (1950). Dementia praecox or the group of schizophrenias. New York: International Universities Press.
  • Budtz-Jørgensen E. (1981). Occlusal dysfunction and stress. J Oral Rehabil 8:1-9.[CrossRef][Medline] [Order article via Infotrieve]
  • Carlson JN, Fitzgerald LW, Keller RW, Glick SD (1991). Side and region dependent changes in dopamine activation with various durations of restraint stress. Brain Res 550:313-318.[CrossRef][Medline] [Order article via Infotrieve]
  • Carlson JN, Fitzgerald LW, Keller RW Jr, Glick SD (1993). Lateralized changes in prefrontal cortical dopamine activity induced by controllable and uncontrollable stress in the rat. Brain Res 630:178-187.[CrossRef][Medline] [Order article via Infotrieve]
  • Carlsson A., Davis JN, Kehr W., Lindqvist M., Atack CV (1972). Simultaneous measurement of tyrosine and tryptophan hydroxylase activities in brain in vivo using an inhibitor of the aromatic amino acid decarboxylase. Naunyn Schmiedeberg's Arch Pharmacol 275:153-168.[CrossRef][Medline] [Order article via Infotrieve]
  • Casey DE (1995). Tardive dyskinesia: pathophysiology. In: Psychopharmacology. The fourth generation of progress. Bloom FE, Kupfer DJ, editors. New York: Raven Press, pp. 1497-1502.
  • Castro SL, Sved AF, Zigmond MJ (1996). Increased neostriatal tyrosine hydroxylation during stress: role of extracellular dopamine and excitatory amino acid. J Neurochem 66:824-833.[Medline] [Order article via Infotrieve]
  • Cenci MA, Kalen P., Mandel RJ, Bjorklund A. (1992). Regional differences in the regulation of dopamine and noradrenaline release in medial frontal cortex, nucleus accumbens and caudate-putamen: a microdialysis study in the rat. Brain Res 581:217-228.[CrossRef][Medline] [Order article via Infotrieve]
  • Ernst AM (1967). Mode of action of apomorphine and dexamphetamine on gnawing compulsion in rats. Psychopharmacologia 10:316-323.[CrossRef][Medline] [Order article via Infotrieve]
  • FitzGerald PM, Jankovic J., Glaze DG, Schultz R., Percy AK (1990). Extrapyramidal involvement in Rett's syndrome. Neurology 40:293-295.[Abstract/Free Full Text]
  • Ghika J., Regli F., Growdon JH (1993). Sensory symptoms in cranial dystonia: a potential role in the etiology? J Neurol Sci 116:142-147.[CrossRef][Medline] [Order article via Infotrieve]
  • Gomez FM, Areso MP, Giralt MT, Sainz B., Garcia-Vallejo P. (1998). Effects of dopaminergic drugs, occlusal disharmonies and chronic stress on non-functional masticatory activity in the rat assessed by incisal attrition. J Dent Res 77:1454-1464.
  • Hamba M., Hisamitsu H., Muro M. ( 1990). Nociceptive projection from tooth pulp to the lateral hypothalamus in rats. Brain Res Bull 25:355-364.[CrossRef][Medline] [Order article via Infotrieve]
  • Harper JA, Labuszewski T., Lidski TI (1979). Substantia nigra unit responses to trigeminal sensory stimulation. Exp Neurol 65:462470.[Medline] [Order article via Infotrieve]
  • Hierholzer J., Cordes M., Schelosky L., Richter W., Keske U., Venz S., et al. (1994). Dopamine receptor imaging with iodine-123-iodobenzamide SPECT in idiopathic rotational torticollis. J Nucl Med 35:1921-1927.[Abstract/Free Full Text]
  • Huston JP, Steiner H., Weiler H.-T, Morgan S., Schwarting RK (1990). The basal ganglia-orofacial system: studies on neurobehavioral plasticity and sensory-motor tuning. Neurosci Biobehav Rev 14:433-446.[Medline] [Order article via Infotrieve]
  • Iuvone PM, Dunn AJ ( 1986). Tyrosine hydroxylase activation in mesocortical 3,4-dihydroxyphenylethylamine neurons following footshock. J Neurochem 47:837-844.[Medline] [Order article via Infotrieve]
  • Keller RW Jr, Stricker EM, Zigmond MJ (1983). Environmental stimuli but not homeostatic challenges produce apparent increases in dopaminergic activity in the striatum: an analysis by in vivo voltammetry. Brain Res 279:159-170.[CrossRef][Medline] [Order article via Infotrieve]
  • Kelley AE, Lang CG, Gauthier AM (1988). Induction of oral stereotypy following amphetamine microinjection into a discrete subregion of the striatum. Psychopharmacology 95:556-559.[Medline] [Order article via Infotrieve]
  • Koshikawa N., Tomiyama K., Omiya K., de Beltran KK, Kobayashi M. (1990). Dopamine D-1 but not D-2 receptor stimulation of the dorsal striatum potentiates apomorphine-induced jaw movements in rats. Eur J Pharmacol 178:189-194.[Medline] [Order article via Infotrieve]
  • Kramarcy NR, Delanoy RL, Dunn AJ ( 1984). Footshock treatment activates catecholamine synthesis in slices of mouse brain regions. Brain Res 290:311-319.[Medline] [Order article via Infotrieve]
  • Krogh-Poulsen WG, Olsson A. (1966). Occlusal disharmonies and dysfunction of the stomatognathic system. Dent Clin North Am 10:627-635.
  • Landgren S., Olsson KA (1980). The effect of electrical stimulation in the hypothalamus on the monosynaptic jaw closing and the disynaptic jaw opening reflexes in the cat. Exp Brain Res 39:389-400.[Medline] [Order article via Infotrieve]
  • Lobbezoo F., Soucy J.-P, Montplaisir JY, Lavigne GJ (1996). Striatal D2 receptor binding in sleep bruxism: a controlled study with iodine-123-iodobenzamide and single-photon-emission computed tomography. J Dent Res 75:1804-1810.
  • Lobbezoo F., Soucy J.-P, Hartman NG, Montplaisir JY, Lavigne GJ (1997). Effects of the D2 receptor agonist bromocriptine on sleep bruxism: report of two single-patient clinical trials. J Dent Res 76:1610-1614.
  • Maeda H., Mogenson GJ (1982). Effects of peripheral stimulation on the activity of neurons in the ventral tegmental area, substantia nigra and midbrain reticular formation of rats. Brain Res Bull 8:7-14.[CrossRef][Medline] [Order article via Infotrieve]
  • Magee KR (1970). Bruxism related to levodopa therapy (letter). J Am Med Assoc 214:147.[Abstract/Free Full Text]
  • McEwen BS, Brinton RE, Sapolsky RM (1988). Glucocorticoid receptors and behavior: implications for the stress response.
  • Adv Exp Med Biol 245:35-45.
  • Murrin LC, Roth RH ( 1976). Dopaminergic neurons: effects of electrical stimulation on dopamine biosynthesis. Mol Pharmacol 12:463-475.[Abstract/Free Full Text]
  • Myers DE, Schooler NR, Zullo TG, Levin H. (1993). A retrospective study of the effects of edentulism on the severity rating of tardive dyskinesia. J Prosthet Dent 69:578-581.[Medline] [Order article via Infotrieve]
  • Nishioka GJ, Montgomery MT (1988). Masticatory muscle hyperactivity in temporomandibular disorders: is it an extrapyramidally expressed disorder? J Am Dent Assoc 116:514520. Okeson JP (1995). Occlusion and functional disorders of the masticatory sytem. Dent Clin North Am 39:285-300.
  • Pei Q., Zetterstrom T., Fillenz M. (1990). Tail pinch-induced changes in the turnover and release of dopamine and 5hydroxytryptamine in different brain regions of the rat. Neuroscience 35:133-138.[CrossRef][Medline] [Order article via Infotrieve]
  • Perlmutter JS, Stambuk MK, Markham J., Black KJ, McGee-Minnich L., Jankovic J., et al. (1997). Decreased [18F] spiperone binding in putamen in idiopathic focal dystonia. J Neurosci 17:843-850.[Abstract/Free Full Text]
  • Pi F., Garcia-Sevilla JA (1992). {alpha}2-autoreceptor-mediated modulation of tyrosine hydroxylase activity in noradrenergic regions of the rat brain in vivo. Naunyn-Schmiedeberg's Arch Pharmacol 345:653-660.[Medline] [Order article via Infotrieve]
  • Pohto P. (1977). A neuropharmacological approach to experimental bruxism. Proc Finn Dent Soc 73:1-13.[Medline] [Order article via Infotrieve]
  • Pohto P., Sunden-Kuronen B., Alanen E. (1979). Effect of occlusal interference, sedation and centrally acting muscle relaxants on apomorphine-induced oral dyskinesias in rats. Proc Finn Dent Soc 75:85-94.[Medline] [Order article via Infotrieve]
  • Reinhard JF Jr, Bannon MJ, Roth RH ( 1982). Acceleration by stress of dopamine synthesis and metabolism in prefrontal cortex: antagonism by diazepam. Naunyn Schmiedeberg's Arch Pharmacol 318:374-377.[CrossRef][Medline] [Order article via Infotrieve]
  • Rodriguez M., Castellano MA, Palarea MD (1990). Interhemispheric regulation of dopaminergic ascending systems. Life Sci 47:377-384.[CrossRef][Medline] [Order article via Infotrieve]
  • Roth RH, Elsworth JD (1995). Biochemical pharmacology of midbrain dopamine neurons. In: Psychopharmacology. The fourth generation of progress. Bloom FE, Kupfer DJ, editors. New York: Raven Press, pp. 227-243.
  • Rugh JD, Barghi N, Drago CJ (1984). Experimental occlusal discrepancies and nocturnal bruxism. J Prosthet Dent 51:548-553. Schneider JS, Lidsky TI (1981). Processing of somatosensory information in striatum of behaving cats. J Neurophysiol 45:841-851.
  • Schroder J, Bubeck B, Silvestri S, Demisch S, Sauer H (1997).
  • Schwarting RK, Steiner H., Huston JP (1990). Effects of hemivibrissotomy in the rat: time-dependent asymmetries in turning and biogenic amines induced by apomorphine. Pharmacol Biochem Behav 35:989-994.[Medline] [Order article via Infotrieve]
  • Schwarting RK, Pei G., Soderstrom S., Ebendal T., Huston JP (1994). Unilateral stimulation or removal of rat vibrissae: analysis of nerve growth factor and tyrosine hydroxylase mRNA in the rat. Behav Brain Res 60:63-71.[CrossRef][Medline] [Order article via Infotrieve]
  • Shibasaki T., Tsumori C., Hotta M., Imaki T., Yamada K., Demura H. (1995). The response pattern of noradrenaline release to repeated stress in the hypothalamic paraventricular nucleus differs according to the form of stress in rats. Brain Res 670:169-172.[CrossRef][Medline] [Order article via Infotrieve]
  • Shoji Y.-N, Bruce IC, Siu LY (1994). Electromyographic assessment of non-functional masseter muscle in an awake animal model. Cranio 12:110-113.[Medline] [Order article via Infotrieve]
  • Smith MA, Brady LS, Glowa J., Gold PW, Herkenham M. (1991). Effects of stress and adrenalectomy on tyrosine hydroxylase mRNA levels in the locus ceruleus by in situ hybridization. Brain Res 544:26-32.[CrossRef][Medline] [Order article via Infotrieve]
  • Steiner H, Weiler H-T, Morgan S, Huston JP (1992). Time-dependent neuroplasticity in mesostriatal projections after unilateral removal of vibrissae in the adult rat: compartment-specific effects on horseradish peroxidase transport and cell size. Neuroscience 47:793-806. Sunden-Kuronen B, Pohto P, Alanen E (1983). Influence of central dopaminergic and oral sensory stimulation on the tone of the rat masseter muscle. Acta Odontol Scand 41:159-166. Swiergiel AH, Peters G (1987). Injection of noradrenaline into the hypothalamic paraventricular nucleus produces vigorous gnawing in satiated rats. Life Sci 41:2251-2254.
  • Trub M, Mei N (1991). Effects of periodontal stimulation on VHM neurons in anesthetized rats. Brain Res Bull 27:29-34. Valentino RJ, Aston-Jones GS (1995). Physiological and anatomical determinants of locus coeruleus discharge. Behavioral and clinical implications. In: Psychopharmacology. The fourth generation of progress. Bloom FE, Kupfer DJ, editors. New York: Raven Press, pp. 373-385.
  • Weiner S, Shaikh MB, Siegel A (1993). Electromyographic activity in the masseter muscle resulting from stimulation of hypothalamic behavioral sites in the cat. J Orofac Pain 7:370-377. Wooten MP, Jankovic J (1990). Bruxism in cranial-cervical dystonia (abstract). Neurology 40(Suppl 1):142.

Journal of Dental Research, Vol. 78, No. 6, 1204-1213 (1999)
DOI: 10.1177/00220345990780060301
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