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Inhibition of Tooth Eruption in the Rat by a Bisphosphonate

Department of Veterinary Anatomy and Cell Biology, School of Veterinary Medicine, Louisiana State University. Baton Rouge, Louisiana 70803-8408

G.E. Wise

Department of Veterinary Anatomy and Cell Biology, School of Veterinary Medicine, Louisiana State University. Baton Rouge, Louisiana 70803-8408

Studies of osteopetrotic rodents suggest that localized alveolar bone resorption must occur if the tooth is to To test this hypothesis directly, we injected postnatal rats with pamidronate, a bisphosphonate that reduces bone resorption by osteoclasts, The results of these experiments demonstrate that this bisphosphonate inhibits the time of tooth of both rat molars and incisors. Pamidronate does not inhibit the gene expression of the putative tooth eruption molecules, colony-stimulating factor-1 and c-fos, both of which are expressed in the dental follicle, the tissue that is required for eruption to occur. Pamidronate does increase the size of the osteoclasts, including an increase in the number of nuclei, suggesting that the precursor mononuclear cells can still fuse to form osteoclasts despite the reduced ability of the osteoclasts to resorb bone, Thus, we report the discovery of an agent that inhibits tooth eruption and also show that tooth eruption requires alveolar bone resorption.

Key Words: bone resorption • osteoclasts • pamidronate • tooth eruption.

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Journal of Dental Research, Vol. 77, No. 1, 8-15 (1998)
DOI: 10.1177/00220345980770011201


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Grier, R.L. Articles by Wise, G.E. Search for Related Content PubMed PubMed Citation Articles by Grier, R.L., IV Articles by Wise, G.E. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Social Bookmarking                         What's this?