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Distribution of Fluoride in the Oral Cavity after Application of a Bioadhesive Fluoride-releasing Tablet

Department of Restorative Dentistry, Free University of Brussels, Laarbeeklaan 103, 1090 Brussels, Belgium

C. Bultmann

Department of Operative Dentistry and Periodontology, Medical Faculty, Technical University of Aachen, Germany

H.G. Gräber

Department of Operative Dentistry and Periodontology, Medical Faculty, Technical University of Aachen, Germany

Bioadhesive fluoride tablets are fluoride-releasing devices that can be applied to the oral mucosa by the patient and release fluoride for several hours. From earlier research, it is known that a single fluoride source in the mouth can lead to an uneven distribution of fluoride in the oral cavity. In this study, fluoride concentrations were determined at different sites of the oral cavities of 13 healthy human volunteers after the application of a bioadhesive fluoride tablet containing 0.5 mg fluoride. The sites were: (1) labial surfaces of the upper central incisors, (2) lingual surfaces of the lower central incisors, (3) labial surface of the first upper left molar, and (4) labial surface of the lower right first molar. The tablet was fixed either centrally on the palate or in the lower labial sulcus in two consecutive experiments. Saliva was sampled with polyethylene sponges 5, 10, 20, 30, 60, 120, 180, and 240 minutes after tablet insertion. Fluoride was determined electrochemically. It could be shown that the area under the curve (AUC) values were significantly (p < 0.05) higher after tablet insertion in the lower labial sulcus at sampling site 1, a trend (p = 0.06) could be calculated for sampling sites 2 and 3, and no difference was found at sampling site 4. Fluoride could be detected in concentrations above 0.01 mmol.L-1 at all sampling sites after tablet insertion in the lower labial sulcus. This location seems to be a more appropriate tablet location than the palate.

Key Words: slow-release • fluoride • saliva • drug monitoring.

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Journal of Dental Research, Vol. 77, No. 1, 68-72 (1998)
DOI: 10.1177/00220345980770010701


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Bottenberg, P. Articles by Gräber, H.G. Search for Related Content PubMed PubMed Citation Articles by Bottenberg, P. Articles by Gräber, H.G. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Social Bookmarking                         What's this?