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The Effect of a Fluoridated Toothpaste on Dentinal Lesions in Plaque-filled Grooves: An Intra-oral Crossover Study

Department of Cariulogy and Endodontology, Academic Centre for Dentistry Amsterdam (ACTA), 1066 EA Amsterdam, The Netherlands

J.J.M. Damen

Department of Cariulogy and Endodontology, Academic Centre for Dentistry Amsterdam (ACTA), 1066 EA Amsterdam, The Netherlands

J.M. ten Cate

Department of Cariulogy and Endodontology, Academic Centre for Dentistry Amsterdam (ACTA), 1066 EA Amsterdam, The Netherlands

Recently, we introduced an intra-oral dentin demineralization model to evaluate the efficacy of a fluoridated toothpaste at plaque-retention sites with limited access to salivary components and fluoride. Usage of the fluoridated toothpaste reduced mineral loss from grooves in sound dentin by 15% compared with a non-fluoridated toothpaste (Lagerweij et al., 1997). In the current study, preformed dentinal lesions were subjected to similar toothpaste treatments. To improve the power of the model in discriminating between toothpaste groups, we changed the design from monadic to crossover to reduce the influence of variation between the participants. Two sets of specimens were placed in the partial prostheses of 29 participants who used a toothpaste containing either 1000 ppm fluoride or no fluoride during two consecutive six-week periods. Changes in mineral content were analyzed by transverse microradiography. The average mineral loss after the non-fluoride period was 1785 vol% x µm (SD 2399), and 1335 vol% x µm (SD 2039) after the fluoride period, a 25% inhibition in demineralization. Analysis of variance showed that the demineralization was significantly influenced not only by the type of treatment (p < 0.001 level), but also by the participant (p < 0.001), the width of the groove (p < 0.001), and the depth into the groove where changes in mineral content were measured (p < 0.017). Twenty-one percent of all the lesions showed remineralization. No significant difference in the extent or the occurrence of remineralization was found between the treatments.

Key Words: caries • dentin • fluoride • grooves • toothpaste • Received October 9 • 1995 • Accepted April 24 • 1996

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Journal of Dental Research, Vol. 75, No. 9, 1687-1691 (1996)
DOI: 10.1177/00220345960750091101


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Lagerweij, M.D. Articles by ten Cate, J.M. Search for Related Content PubMed PubMed Citation Articles by Lagerweij, M.D. Articles by ten Cate, J.M. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Social Bookmarking                         What's this?