This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Igar, K. Articles by Shinoda, H. Search for Related Content PubMed PubMed Citation Articles by Igar, K. Articles by Shinoda, H. Social Bookmarking                         What's this?

Inhibitory Effect of the Topical Administration of a Bisphosphonate (Risedronate) on Root Resorption Incident to Orthodontic Tooth Movement in Rats

Department of Orthodontics

H. Adachi

Department of Orthodontics

H. Mitani

Department of Orthodontics

H. Shinoda

Pharmacology, School of Dentistry, Tohoku University, 4-1 Seiryo-machi, Aoba-ku,Sendai, 980-77, Japan

Root resorption associated with tooth movement is an unsolved problem in orthodontics. If such root resorption could be prevented, it would be an important contribution toward reducing risk factors in orthodontic treatment. The purpose of this study was to examine the effects of the topical administration of a bisphosphonate, risedronate, which is known to be a potent blocker of bone resorption, on root resorption during tooth movement and on the repair of the resorbed root surface after tooth movement in rats. In the first experiment, both the right and left upper first molars were moved buccally with a standardized expansion spring under administration of risedronate. After day 7, extensive root resorption had occurred on the control side, and the area of root resorption reached a maximum on day 14. The topical administration of risedronate caused a significant and dose-dependent inhibition of root resorption after the orthodontic force was applied. In the second experiment, the right and left upper molars were first moved buccally for 3 weeks. Risedronate treatment began on the day the spring was removed. After the force was withdrawn, the resorbed root surfaces on both the control and risedronate-treated sides were gradually restored by apposition of repair cementum (cementoid). The topical administration of risedronate did not appear to inhibit the repair process of root resorption. These results suggest that the topical administration of risedronate may be useful in preventing root resorption of teeth during orthodontic treatment.

Key Words: bisphosphonate • root resorption • tooth movement • orthodontics • rats.

REFERENCES

• Adachi H., Igarashi K., Mitani H., Shinoda H. (1994). Effects of topical administration of a bisphosphonate (risedronate) on orthodontic tooth movements in rats. J Dent Res 73:1478-1486.
• Andreasen JO (1988). Review of root resorption systems and models, Etiology of root resorption and the homeostatic mechanisms of the periodontal ligament. In: The biological mechanisms of tooth eruption and root resorption. Davidovitch Z, editor. Birmingham, AL: EBSCO Media, pp. 9-22.
• Brezniak N., Wasserstein A. (1993a). Root resorption after orthodontic treatment: Part 1. Literature review. Am J Orthod Dentofac Orthop 103:62-66.[Medline] [Order article via Infotrieve]
• Brezniak N., Wasserstein A. (1993b). Root resorption after orthodontic treatment: Part 2. Literature review. Am J Orthod Dentofac Orthop 103:138-146.[Medline] [Order article via Infotrieve]
• Brudvik P., Rygh P. ( 1993). The initial phase of orthodontic root resorption incident to local compression of the periodontal ligament. Eur J Orthod 15:249-263.[Abstract/Free Full Text]
• Engstrom C. (1988). Root resorption during orthodontic tooth movement and bone remodelling dynamics during hypocalcemia and treatment with bisphosphonate. In: The biological mechanisms of tooth eruption and root resorption. Davidovitch Z, editor. Birmingham, AL: EBSCO Media, pp. 391-397.
• Farrell L., Yen EHK, Brudvik P., Rygh P., Suga DM ( 1990). Identification of orthodontically induced root resorptive cells using TRAP stain (abstract). J Dent Res 69:201.
• Flanagan AM, Chambers TJ (1989). Dichloromethylene-bisphosphonate (Cl2MDP) inhibits bone resorption through injury to osteoclasts that resorb Cl2MDP-coated bone. Bone Miner 6:33-43.[CrossRef][Medline] [Order article via Infotrieve]
• Fleisch H. (1990). The possible use of bisphosphonates in osteoporosis. In: Osteoporosis: Physiological basis, assessment, and treatment. DeLuca HF, Mazess R, editors. Amsterdam: Elsevier Science Publishing Co., Inc., pp. 323-329.
• Fleisch H. (1991). Bisphosphonates pharmacology and use in the treatment of tumour-induced hypercalcaemic and metastatic bone disease. Drugs 42:919-944.[Medline] [Order article via Infotrieve]
• Fleisch H. (1993). Bisphosphonates in bone disease-From the laboratory to the patient. Berne: Herbert Fleisch.
• Furseth R. (1968). The resorption processes of human deciduous teeth studied by light microscopy, microradiography and electron microscopy. Arch Oral Biol 13:417-431.[CrossRef][Medline] [Order article via Infotrieve]
• Hughes DE, Wright KR, Uy HL, Sasaki A., Yoneda T., Roodman GD, et al. (1995). Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo. J Bone Miner Res 10:1478-1487.[Medline] [Order article via Infotrieve]
• Igarashi K., Mitani H., Adachi H., Shinoda H. (1994). Anchorage and retentive effects of a bisphosphonate (AHBuBP) on tooth movements in rats. Am J Orthod Dentofac Orthop 106:279-289.[Medline] [Order article via Infotrieve]
• Jung A., Bisaz S., Fleisch H. (1973). The binding of pyrophosphate and two bisphosphonates on hydroxyapatite crystals. Calcif Tissue Res 11:269-280.[Medline] [Order article via Infotrieve]
• Matsumoto Y. (1994). Morphological and functional properties of odontoclasts on dentine resorption. J Stomatol Soc Jpn 61:123-143.
• Miller SC, Jee WSS (1977). The comparative effects of dichloromethylene diphosphonate (Cl2MDP) and ethane-1-hydroxy-1,1-diphosphonate (EHDP) on growth and modeling of the rat tibia. Calcif Tissue Res 23:207-214.[CrossRef][Medline] [Order article via Infotrieve]
• Miihlbauer RC, Bauss F., Schenk R., Janner M., Bosies E., Strein K., et al. (1991). BM 21.0955, a potent new bisphosphonate to inhibit bone resorption. J Bone Min Res 6:1003-1011.[Medline] [Order article via Infotrieve]
• Plasmans CMI, Jap PHK, Kuijpers W., Slooff Tjjh (1980). Influence of a diphosphonate on the cellular aspect of young bone tissue. Calcif Tissue Int 32:247-266.[CrossRef][Medline] [Order article via Infotrieve]
• Sasaki T., Takahashi N., Watanabe C., Suzuki H., Higashi S., Suda T. ( 1988). Cytodifferentiation of odontoclasts in physiologic root resorption of human deciduous teeth. In: The biological mechanisms of tooth eruption and root resorption. Davidovitch Z, editor. Birmingham, AL: EBSCO Media, pp. 321-328.
• Sato M., Grasser W., Endo N., Akins R., Simmons H., Thompson DD, et al. (1991). Bisphosphonate action: Alendronate localization in rat bone and effects on osteoclast ultrastructure. J Clin Invest 88:2095-2105.[Medline] [Order article via Infotrieve]
• Schenk R., Merz WA, Miihlbauer R., Russell RGG, Fleisch H. (1973). Effect of ethane-1-hydroxy-1,1-diphosphonate (EHDP) and dichloromethylene diphosphonate (Cl2MDP) on the calcification and resorption of cartilage and bone in the tibial epiphysis and metaphysis of rats. Calcif Tissue Res 11:196-214.[Medline] [Order article via Infotrieve]
• Tronstad L. (1988). Root resorption-a multidisciplinary problem in dentistry. In: The biological mechanisms of tooth eruption and root resorption. Davidovitch Z, editor. Birmingham, AL: EBSCO Media, pp. 293-302.
• van der Pluijm G., Lowik Cwgm, de Groot H., Alblas MJ, van der Wee-Pals LJA, Bijvoet OLM, et al. (1991). Modulation of PTH-stimulated osteoclastic resorption by bisphosphonates in fetal mouse bone explants. J Bone Min Res 6:1203-1210.[Medline] [Order article via Infotrieve]
• Wesselink PR, Beertsen W. (1988). Initiating factors in dental root resorption. In: The biological mechanisms of tooth eruption and root resorption. Davidovitch Z, editor. Birmingham, AL: EBSCO Media, pp. 329-334.
• Wronski TJ, Yen C.-F, Scott KS (1991). Estrogen and diphosphonate treatment provide long-term protection against osteopenia in ovariectomized rats. J Bone Min Res 6:387-394.[Medline] [Order article via Infotrieve]

Journal of Dental Research, Vol. 75, No. 9, 1644-1649 (1996)
DOI: 10.1177/00220345960750090501


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				Y. Fujimura, H. Kitaura, M. Yoshimatsu, T. Eguchi, H. Kohara, Y. Morita, and N. Yoshida Influence of bisphosphonates on orthodontic tooth movement in mice Eur J Orthod, December 1, 2009; 31(6): 572 - 577. [Abstract] [Full Text] [PDF]

				O. Teronen, Y.T. Konttinen, C. Lindqvist, T. Salo, T. Ingman, A. Lauhio, Y. Ding, S. Santavirta, and T. Sorsa Human Neutrophil Collagenase MMP-8 in Peri-implant Sulcus Fluid and its Inhibition by Clodronate Journal of Dental Research, September 1, 1997; 76(9): 1529 - 1537. [Abstract] [PDF]

This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Igar, K. Articles by Shinoda, H. Search for Related Content PubMed PubMed Citation Articles by Igar, K. Articles by Shinoda, H. Social Bookmarking                         What's this?