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Journal of Dental Research
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Bilateral Reflex Vasodilation in the Palatal Mucosa Evoked by Unilateral Tooth-pulp Stimulation in the Cat

In a previous study in cats, we found that electrical stimulation of the tooth pulp caused blood flow increases at various sites in the ipsilateral oral mucosa (upper and lower gingivae, lower lip, buccal mucosa and tongue, and, notably, bilaterally in the palatal mucosa). Tooth-pulp stimulation is well-known to induce severe pain and to evoke autonomic reflex responses in other organs and tissues. The purpose of this study was: to confirm that tooth-pulp stimulation may indeed induce autonomically mediated vasodilator responses in the feline oral mucosa away from the stimulated tooth, and to test our hypothesis that the reflex pathway involves parasympathetic vasodilator fibers as efferents. Dynamic changes in palatal mucosal blood flow (PMBF), with lower lip blood flow (LBF) as a control, were investigated in anesthetized, cervically sympathectomized cats by means of Laser Doppler Flowmetry. Unilateral electrical stimulation of the maxillarv canine tooth pulp produced hexamethonium-sensitive bilateral increases in PMBF in a stimulus-intensity-dependent manner, without an increase in systemic blood pressure; LBF increased only ipsilaterally. Bilateral section of the glossopharyngeal nerve roots had no effect on the vasodilator responses, while unilateral section of the facial nerve root or lesion of the pterygopalatine ganglion (PPG) abolished the response on that side. Intracranial electrical stimulation of the peripheral cut ends of the facial or glossopharyngeal nerve roots caused an increase in ipsilateral PMBF. These results indicate that unilateral tooth-pulp stimulation induces a bilateral reflex vasodilator response in the palatal mucosa mediated viaparasympathetic vasodilator fibers that emerge from the brain stem with the facial nerve and reach the blood vessels viaPPG. Although there is a dual innervation of the cat palatal mucosa by parasympathetic vasodilator fibers running viathe facial and glossopharyngeal nerve roots, the latter are not involved in the bilateral reflex responses.

Key Words: somato-parasympathetic reflex vasodilation • bilateral reflex vasodilation • palatal mucosal blood flow • tooth pulp stimulation.

REFERENCES

  • Aars H., Gazelius B., Edwall L., Olgart L. (1992). Effects of autonomic reflexes on tooth pulp blood flow in man. Acta Physiol Scand 146:433-429.
  • Anggard A. (1974). The effects of parasympathetic nerve stimulation on the microcirculation and secretion in the nasal mucosa of the cat. Acta Otolaryngol 78:98-105.[CrossRef][Medline] [Order article via Infotrieve]
  • Bell C., Janig W., Kummel H., Xu H. (1985). Differentiation of vasodilator and sudomotor responses in the cat paw pad to preganglionic sympathetic stimulation. J Physiol 364:93-104.[Abstract/Free Full Text]
  • Byers MR (1984). Dental sensory receptors. Int Rev Neurobiol 25:39-94.[Medline] [Order article via Infotrieve]
  • Chorobski J., Penfield W. (1932). Cerebral vasodilator nerves and their pathway from the medulla oblongata: with observations on the pial and intracerebral vascular plexus. Arch Neurol Psychiatry 28:1257-1289.[Abstract/Free Full Text]
  • Dellow PG, Morgan MJ (1969). Trigeminal nerve inputs and central blood pressure change in the cat. Arch Oral Biol 14:295-300.[Medline] [Order article via Infotrieve]
  • Fried K., Aldskogius H., Hildebrand C. (1988). Proportion of unmyelinated axons in rat molar and incisor tooth pulps following neonatal capsaicin treatment and/or sympathectomy. Brain Res 463:118-123.[CrossRef][Medline] [Order article via Infotrieve]
  • Izumi H., Karita K. (1991). Vasodilator responses following intracranial stimulation of the trigeminal, facial and glossopharyngeal nerves in cat gingiva. Brain Res 560:71-75.[Medline] [Order article via Infotrieve]
  • Izumi H., Karita K. (1992). Somatosensory stimulation causes autonomic vasodilation in cat lip. J Physiol (Lond) 450:191-202.[Abstract/Free Full Text]
  • Izumi H., Karita K. (1993a). Reflex vasodilation in the cat lip evoked by stimulation of vagal afferents. J Autonom Nerv Syst 42:215-223.[Medline] [Order article via Infotrieve]
  • Izumi H., Karita K. (1993b). Reflex vasodilation in the cat lip elicited by stimulation of nasal mucosa by chemical irritants. Am J Physiol 265:R733-R738.[Medline] [Order article via Infotrieve]
  • Johansson B. (1962). Circulatory responses to stimulation of somatic afferents, with special reference to depressor effects from muscular nerves. Acta Physiol Scand 57(Suppl 198):1-91.[CrossRef]
  • Karita K., Izumi H. (1992a). Somatosensory afferents in the parasympathetic vasodilator reflex in cat lip. J Autonom Nerv Syst 39:229-234.[CrossRef][Medline] [Order article via Infotrieve]
  • Karita K., Izumi H. (1992b). Innervation areas of afferents and efferents in somato-autonomic vasodilator reflex in the orofacial areas of the cat. Pain Res 7:105-114.
  • Karita K., Izumi H. (1994). Reflex vasodilation in cat lower lip elicited by noxious stimulation of the nasal mucosa. Pain Res 9:95-98 (in Japanese, abstract in English).
  • Kemppainen P., Leppanen H., Jyvasjarvi E., Pertovaara A. (1994). Blood flow increase in the orofacial area of humans induced by painful stimulation. Brain Res Bull 33:655-662.[CrossRef][Medline] [Order article via Infotrieve]
  • Kuchiiwa S. (1990). Intraocular projections from the pterygopalatine ganglion in the cat. J Comp Neurol 300:301-308.[Medline] [Order article via Infotrieve]
  • Kuchiiwa S., Kuchiiwa T., Nakagawa S. (1994). Mode of autonomic and sensory nerve supplies to the cat palatine gland as revealed by a WGA-HRP method (abstract). Neurosci Res 19(Suppl 2018):230.
  • Lisney SJ, Matthews B. (1978). Branched afferent nerves supplying tooth-pulp in the cat. J Physiol (Lond) 279:509-517.[Abstract/Free Full Text]
  • Lundberg JM, Anggard A., Fahrenkrug J. (1981a). Complementary role of vasoactive intestinal polypeptide (VIP) and acetylcholine for cat submandibular gland blood flow and secretion, I. VIP release. Acta Physiol Scand 113:317-327.
  • Lundberg JM, Anggard A., Fahrenkrug J. (1981b). Complementary role of vasoactive intestinal polypeptide (VIP) and acetylcholine for cat submandibular blood flow and secretion, II. Effects of cholinergic antagonists and VIP antiserum. Acta Physiol Scand 114:329-336.
  • Lundberg JM, Anggard A., Fahrenkrug J. (1982). VIP as a mediator of hexamethonium-sensitive, atropine-resistant vasodilation in the cat tongue. Acta Physiol Scand 116:387-392.[Medline] [Order article via Infotrieve]
  • Lundberg J., Norgren L., Ribbe E., Rosen I., Steen S., Thome J., et al.(1989). Direct evidence of active sympathetic vasodilation in the skin of the human foot. J Physiol (Lond) 417:437-446.[Abstract/Free Full Text]
  • Nilsson SF, Linder J., Bill A. ( 1985). Characteristics of uveal vasodilation produced by facial nerve stimulation in monkeys, cats and rabbits. Exp Eye Res 40:841-852.[CrossRef][Medline] [Order article via Infotrieve]
  • Nomura S., Yasui Y., Takada M., Mizuno N. (1984). Trigeminal primary afferent neurons projecting directly to the solitary nucleus in the cat: a transganglionic and retrograde horseradish peroxidase study. Neurosci Lett 50:257-262.[Medline] [Order article via Infotrieve]
  • Nordin M. (1990). Sympathetic discharges in the human supraorbital nerve and their relation to pseudo- and vasomotor responses. J Physiol 423:241-255.[Abstract/Free Full Text]
  • Robinson PP (1979). The course, relations and distribution of the inferior alveolar nerve and its branches in the cat. Anat Rec 195:265-271.[Medline] [Order article via Infotrieve]
  • Sasano T., Kuriwada S., Shoji N., Sanjo D., Izumi H., Karita K. (1994). Axon reflex vasodilation in cat dental pulp elicited by noxious stimulation of the gingiva. J Dent Res 73:1797-1802.
  • Sasano T., Shoji N., Kuriwada S., Sanjo D. (1995a). Calibration of laser Doppler flowmetry for measurement of gingival blood flow. J Periodont Res 30:298-301.[Medline] [Order article via Infotrieve]
  • Sasano T., Shoji N., Kuriwada S., Sanjo D., Izumi H., Karita K. (1995b). Absence of parasympathetic vasodilation in cat dental pulp. J Dent Res 74:1665-1670.
  • Shoji N., Sasano T., Kuriwada S., Sanjo D. (1993). Characteristic pulpal vasodilation induced by antidromical inferior alveolar nerve stimulation (abstract). J Dent Res 72(Spec Iss):784.
  • Shoji N., Sasano T., Kuriwada S., Sanjo D. (1995). Reflex vasodilation in oral mucosa evoked by pulp stimulation in the cat (abstract). J Dent Res 74:969.
  • Van Buren J., Kleinknecht RA (1979). An evaluation of the McGill pain questionnaire for use in dental pain assessment. Pain 6:23-33.[Medline] [Order article via Infotrieve]

Journal of Dental Research, Vol. 75, No. 9, 1637-1643 (1996)
DOI: 10.1177/00220345960750090401
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This Article
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