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EP-GP and the Lipocalin VEGh, Two Different Human Salivary 20-kDa Proteins
Leon C.P.M. Schenkels
Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), Vrije Universiteit, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
Enno C.I. Veerman
Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), Vrije Universiteit, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
Arie V. Nieuw Amerongen
Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), Vrije Universiteit, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
Two salivary 20-kDa proteins [the human lipocalin Von Ebner's gland protein (VEGh) and extra-parotid glycoprotein (EP-GP)] show several remarkable similarities and differences. The latter is identical to secretory actin-binding protein (SABP), gross cystic disease fluid protein-15 (GCDFP-15), prolactin-induced protein (PIP), and 17-kDA CD4-binding glycoprotein (gpl7). Much is known about the distribution, localization, biochemical characteristics, and molecular biology of these two proteins, yet there are only few clues about their functions.
Key Words: EP-GP lipocalin pre-albumin SABP VEG
REFERENCES
- Akerstrom B., Logdberg L. (1990). An intriguing member of the lipocalin protein family: β1-microglobulin. TIBS 15:240-243. Akiyama K., Kimura H. (1990). Isolation of a new actin-binding protein from human seminal plasma. Biochim Biophys Acta 1040:206-210.[CrossRef][Medline]
[Order article via Infotrieve]
- Autiero M., Cammarota G., Friedlein A., Zulauf M., Chiappetta G., Dragone V., et al. (1995). A 17 kDa CD4-binding glycoprotein present in human seminal plasma and in breast tumor cells. Eur J Immunol 25:1461-1464.[Medline]
[Order article via Infotrieve]
- Azen EA ( 1976). Genetic polymorphism of human anodal tear protein. Biochem Genet 14:225-235.[Medline]
[Order article via Infotrieve]
- Blais Y., Sugimoto K., Carriere MC, Haagensen DE, Labrie F., Simard J. (1994). Potent stimulatory effect of interleukin-1-alpha on apolipoprotein D and gross cystic disease fluid protein-15 expression in human breast-cancer cells. Int J Cancer 59:400-407.[Medline]
[Order article via Infotrieve]
- Blaker M., Kock K., Ahlers C., Buck F., Schmale H. (1993). Molecular cloning of human Von Ebner's gland protein, a member of the lipocalin superfamily highly expressed in lingual salivary glands. Biochim Biophys Acta 1172:131-137. Bocskei Z., Groom CR, Flower DR, Wright CE, Phillips SE, Cavaggioni A., et al. (1992). Pheromone binding to two rodent urinary proteins revealed by x-ray crystallography. Nature 360:186-188.[CrossRef][Medline]
[Order article via Infotrieve]
- Bonavida B., Sapse AT, Sercarz EE (1969). Specific tear prealbumin: a unique lachrymal protein absent from serum and other secretions. Nature 221:375-376.[CrossRef][Medline]
[Order article via Infotrieve]
- Booth WD, White CA (1988). The isolation, purification and some properties of pheromaxein, the pheromonal steroid-binding protein, in porcine submaxillary glands and saliva. J Endocrinol 118:47-57.[Abstract/Free Full Text]
- Bush TL, Helzlsouer KJ (1993). Tamoxifen for the primary prevention of breast cancer: a review and critique of the concept and trial. Epidemiol Rev 15:233-243.[Free Full Text]
- Cassoni P., Sapino A., Haagensen DE, Naldoni C., Bussolati G. (1995). Mitogenic effect of the 15-kDa gross cystic disease fluid protein (GCDFP-15) on breast-cancer cell lines and on immortal mammary cells. Int J Cancer 60:216-220.[Medline]
[Order article via Infotrieve]
- Chao CC, Butala SM (1986). Isolation and preliminary characterization of tear prealbumin from human ocular mucus. Curr Eye Res 5:895-901.[Medline]
[Order article via Infotrieve]
- Chalbos D., Haagensen D., Parish T., Rochefort H. (1987). Identification and androgen regulation of two proteins released by T47D human breast cancer cells. Cancer Res 47:2787-2792.[Abstract/Free Full Text]
- Chaubert P., Hurlimann J. (1992). Mammary origin of metastases: immunohistochemical determination. Arch Pathol Lab Med 116:1181-1188.[Medline]
[Order article via Infotrieve]
- Dear TN, Campbell K., Rabbitts TH (1991). Molecular cloning of putative odorant-binding and odorant-metabolizing proteins. Biochemistry 30:10376-10382.
- Dejardin L., Gol-Winkler R., Collette J., Delvenne C., Carlisi I., Haagensen DE, et al. (1991). Stimulatory effect of oestradiol-17(3 and tamoxifen on gross cystic disease fluid protein 15,000 production and mRNA levels in T47D human breast cancer cells. J Molec Endocrinol 7:105-112. Eusebi V., Betts C., Haagensen DE Jr, Gugliotta P., Bussolati G., Azzopardi JG (1984). Apocrine differentiation in lobular carcinoma of the breast: a morphologic, immunologic, and ultrastructural study. Hum Pathol 15:134-140.[Medline]
[Order article via Infotrieve]
- Eusebi V., Foschini MP, Betts CM, Gherardi G., Millis RR, Bussolati G., et al. (1993). Microglandular adenosis, apocrine adenosis and tubular carcinoma of the breast: an immunohistochemical comparison. Am J Surg Pathol 17:99-109.[CrossRef][Medline]
[Order article via Infotrieve]
- Flower DR (1994). The lipocalin protein family: a role in cell regulation. FEBS Letts 354:7-11.[CrossRef][Medline]
[Order article via Infotrieve]
- Gachon AM (1993). Lipocalins: do we taste with our tears? Trends Biochem Sci 18:206-207.[Medline]
[Order article via Infotrieve]
- Gachon AM, Richard J., Dastugue B. (1982). Human tears-normal-protein pattern and individual protein determinators in adults. Curr Eye Res 5:301-308.
- Garibotti M., Christiansen H., Schamel H., Pelosi P. (1995). Porcine VEG proteins and tear prealbumins. Chem Senses 20:69-76. Glasgow BJ, Heinzmann C., Kojis T., Sparkes RS, Mohandas T., Bateman JB (1993). Assignment of tear lipocalin gene to human chromosome 9q34-9qter. Curr Eye Res 12:1019-1023. Haagensen DE Jr, Mazoujian G., Dilley WG, Pedersen CE, Kister SJ, Wells SA Jr (1979). Breast gross cystic disease fluid analysis. 1. Isolation and radioimmunoassay for a major component protein. J Natl Cancer Inst 62:239-247. Haagensen DE Jr, Dilley WG, Mazoujian G., Wells SA Jr (1990). Review of GCDFP-15, an apocrine marker protein. Ann NY Acad Sci 586:161-177.[Medline]
[Order article via Infotrieve]
- Haagensen DE, Stewart P., Dilley WG, Wells SA (1992). Secretion of breast gross cystic disease fluid proteins by T47D breast cancer cells in culture-modulation by steroid hormones. Breast Cancer Res Treat 23:77-86.[CrossRef][Medline]
[Order article via Infotrieve]
- Hahnel E., Harvey J., Robbins P., Sterrett G., Hahnel R. (1994). Hormone-regulated genes (pS2, PIP, FAS) in breast cancer and non tumoral mammary tissue. Pathobiol 62:82-89.
- Ham J., Thomson A., Needham M., Webb P., Parker M. (1988). Characterization of response elements for androgens, glucocorticoids and progestins in mouse mammary-tumour virus. Nucleic Acids Res 16:5263-5276.[Abstract/Free Full Text]
- Hashimoto K., Gross BG, Lever WF (1966). Electron microscopic study of apocrine secretion. J Invest Dermatol 46:378-390. Henzel WJ, Rodriguez H., Singer AG, Stults JT, Macrides F., Agosta WC, et al. (1988). The primary structure of
- aphrodisin. J Biol Chem 263:16682-16687.
- Herzog H., Baumgartner M., Holzfeind P., Redl B. ( 1995). Confirmation of 9q34 as the chromosomal site of the human lipocalin LCN1 gene. Cytogenet Cell Genet 69:108-109.[Medline]
[Order article via Infotrieve]
- Ho KC, Quarmby VE, French FS, Wilson EM (1992). Molecular cloning of rat prostate transglutaminase complementary DNA. The major androgen-regulated protein DP1 of rat dorsal prostate and coagulating gland. J Biol Chem 267:12660-12667.[Abstract/Free Full Text]
- Holden HM, Rypniewski WR, Law JH, Rayment I. (1987). The molecular structure of insecticyanin from the tobacco hornworm Manduca sexta L. at 2.6 A resolution. EMBO J 6:1565-1570.[Medline]
[Order article via Infotrieve]
- Holzfeind P., Redl B. ( 1994). Structural organization of the gene encoding the human lipocalin tear prealbumin and synthesis of the recombinant protein in Escherichia coli. Gene 139:177-183.[CrossRef][Medline]
[Order article via Infotrieve]
- Igarashi M., Nagata A., Toh H., Urade Y., Hayaishi O. (1992). Structural organization of the gene for prostaglandin D synthase in the rat brain. Proc Natl Acad Sci USA 89:5376-5380.[Abstract/Free Full Text]
- Inada K. (1984). Studies of human tear proteins. 3. Distribution of specific tear prealbumin in lacrimal glands and other ocular adnexa. Jpn J Ophthalmol 28:315-330.[Medline]
[Order article via Infotrieve]
- Janssen PT, Van Bijsterveld OP (1983). The relations between tear fluid concentrations of lysozyme, tear-specific prealbumin and lactoferrin. Exp Eye Res 36:773-779.[CrossRef][Medline]
[Order article via Infotrieve]
- Jones WK, Yu Lee LY, Clift SM, Brown TL, Rosen JM (1985). The rat casein multigene family. Fine structure and evolution of the (3-casein gene. J Biol Chem 260:7042-7050.[Abstract/Free Full Text]
- Kock K., Blaker M., Schmale H. (1992). Postnatal development of von Ebner's glands: accumulation of a protein of the lipocalin superfamily in taste papillae of rat tongue. Cell Tissue Res 267:313-320.[CrossRef][Medline]
[Order article via Infotrieve]
- Kock K., Ahlers C., Schmale H. (1994a). Structural organization of the genes for rat von Ebner's gland proteins 1 and 2 reveals their close relationship to lipocalins. Eur J Biochem 221:905-916.[Medline]
[Order article via Infotrieve]
- Kock K., Morley SD, Mullins JJ, Schmale J. (1994b). Denatonium bitter tasting among transgenic mice expressing rat von Ebner's gland protein. Physiol Behav 56:1173-1177. Lassagne H., Ressot C., Mattei MG, Gachon AM (1993). Assignment of the human tear lipocalin gene (LCN1) to 9q34 by in situ hybridization. Genomics 18:160-161. Mazoujian G., Pinkus GS, Davis S., Haagensen DE Jr (1983). Immunohistochemistry of a gross cystic disease fluid protein (GCDFP-15) of the breast. A marker of apocrine epithelium and breast carcinomas with apocrine features. Am J Pathol 110:105-112.[Abstract]
- Mazoujian G., Warhol MJ, Haagensen DE Jr (1984). The ultrastructural localization of gross cystic disease fluid protein (GCDFP-15) in breast epithelium. Am J Pathol 116:305-310.[Abstract]
- Mira E., Castano JG (1989). Insulin short-term control of rat liver alpha 2-microglobulin gene transcription. J Biol Chem 264:18209-18212.[Abstract/Free Full Text]
- Monahan JE, Kelton CA (1984). The cDNA cloning of the 15,000 Daltons human breast gross cystic disease fluid protein (abstract). Fed Proc 43:1419.
- Murphy LC, Tsuyuki D., Myal Y., Shiu RP ( 1987). Isolation and sequencing of a cDNA clone for a prolactin-inducible protein (PIP): regulation of PIP gene expression in the human breast cancer cell line, T-47D. J Biol Chem 262:15236-15241.[Abstract/Free Full Text]
- Myal Y., Gregory C., Wang H., Hamerton JL, Shiu RP ( 1989). The gene for prolactin-inducible protein (PIP), uniquely expressed in exocrine organs, maps to chromosome 7. Somat Cell Mol Genet 15:265-270.[CrossRef][Medline]
[Order article via Infotrieve]
- Myal Y., Robinson DB, Iwasiow B., Tsuyuki D., Wong P., Shiu RP ( 1991). The prolactin-inducible protein (PIP/GCDFP-15) gene: cloning, structure and regulation. Molec Cell Endocrinol 80:165-175.[CrossRef][Medline]
[Order article via Infotrieve]
- Myal Y., Iwasiow B., Yarmill A., Harrison E., Paterson JA, Shiu RP ( 1994). Tissue-specific androgen-inhibited gene expression of a submaxillary gland protein, a rodent homolog to the human prolactin-inducible protein/GCDFP-15 gene. Endocrinol 135:1605-1610.[Abstract]
- Nagata A., Suzuki Y., Igarashi M., Eguchi N., Toh H., Urade Y., et al. (1991). Human brain prostaglandin D synthase has been evolutionarily differentiated from lipophilic-ligand carrier proteins. Proc Natl Acad Sci USA 88:4020-4024.[Abstract/Free Full Text]
- Nieuw Amerongen AV, Oderkerk CH, Driessen AA (1987). Role of mucins from human whole saliva in the protection of tooth enamel against demineralization in vitro. Caries Res 21:297-309. Nieuw Amerongen AV, Oderkerk CH, Veerman ECI (1989). Interaction of human salivary mucins with hydroxyapatite. J Biol Buccale 17:85-92.[Medline]
[Order article via Infotrieve]
- North AC (1990). Structural homology in ligand-specific transport proteins. Biochem Soc Symp 57:35-48.[Medline]
[Order article via Infotrieve]
- Pagani A., Eusebi V., Bussolati G. (1994). Detection of PIPGCDFP-15 gene expression in apocrine epithelium of the breast and salivary glands. Appl Immunohistochem 2:29-35. Papiz MZ, Sawyer L., Eliopoulos EE, North AC, Findlay JB, Sivaprasadarao R., et al. (1986). The structure of β-lactoglobulin and its similarity to plasma retinol-binding protein. Nature 324:383-385.[CrossRef][Medline]
[Order article via Infotrieve]
- Paties C., Taccagni GL, Papotti M., Valente G., Zangrandi A., Aloi F. ( 1993). Apocrine carcinoma of the skin: a clinicopathologic, immunocytochemical, and ultrastructural study. Cancer 71:375-381.
- Peitsch MC, Boguski MS (1990). Is apolipoprotein D a mammalian bilin-binding protein? New Biologist 2:197-206. Pervaiz S., Brew K. (1987). Homology and structure-function correlations between β1-acid glycoprotein and serum retinol-binding protein and its relatives. FASEB J 1:209-214. Pevsner J., Reed RR, Feinstein PG, Snyder SH (1988). Molecular cloning of odorant-binding protein: member of a ligand carrier family. Science 241:336-339.[Abstract/Free Full Text]
- Pevsner J., Hou V., Snowman AM, Snyder SH (1990). Odorant-binding protein. Characterization of ligand binding. J Biol Chem 265:6118-6125.[Abstract/Free Full Text]
- Rathman WM, Van Zeyl MJ, Van den Keybus PAM, Bank RA, Veerman ECI, Nieuw Amerongen AV (1989). Isolation and characterization of three non-mucinous human salivary proteins with affinity for hydroxyapatite. J Biol Buccale 17:199-208.[Medline]
[Order article via Infotrieve]
- Rathman WM, Van den Keybus PAM, Van Zeyl MJ, Dopp EA, Veerman ECI, Nieuw Amerongen AV (1990). Characterization of monoclonal antibodies to human salivary (glyco)proteins. Cellular localization of mucin,
- Redl B., Holzfeind P., Lottspeich F. (1992). cDNA cloning and sequencing reveals human tear prealbumin to be a member of the lipophilic-ligand carrier protein superfamily. J Biol Chem 267:20282-20287.[Abstract/Free Full Text]
- Riley CT, Barbeau BK, Keim PS, Kezdy FJ, Heinrikson RL, Law JH (1984). The covalent protein structure of insecticyanin, a blue biliprotein from the hemolymph of the tobacco hornworm, Manduca sexta L. J Biol Chem 259:13159-13165. Rost B., Sander C. (1993). Prediction of protein secondary structure at better than 70% accuracy. J Molec Biol 232:584-599. Schaller J., Akiyama K., Kimura H., Hess D., Affolter M., Rickli EE (1991). Primary structure of a new actin-binding protein from human seminal plasma. Eur J Biochem 196:743-750. Schenkels Lcpm, Rathman WM, Veerman ECI, Nieuw Amerongen AV (1991). Detection of proteins related to a salivary glycoprotein (EP-GP). Concentrations in human secretions (saliva, sweat, tears, nasal mucus, cerumen, seminal plasma). Biol Chem Hoppe-Seyler 372:325-329. Schenkels LCPM, Ligtenberg AJM, Veerman ECI, Nieuw Amerongen AV (1993). Interaction of the salivary glycoprotein EP-GP with the bacterium Streptococcus salivarius HB. J Dent Res 72:1559-1565.
- Schenkels LCPM, Schaller J., Walgreen-Weterings E., Schadee-Eestermans IL, Veerman ECI, Nieuw Amerongen AV (1994). Identity of human extra parotid glycoprotein (EP-GP) with secretory actin binding protein (SABP) and its biological properties. Biol Chem Hoppe-Seyler 375:609-615. Schiefferdecker P. (1922). Die Hautdriisen des Menschen und der Saugetiere, ihre Bedeutung sowie die Muscularis sexualis. Zoologica 75:1-52.
- Schmale H., Ahlers C., Blaker M., Kock K., Spielman AI (1993). Perireceptor events in taste. In: The molecular basis of smell and taste transduction. Ciba Foundation Symposium 179. Chichester: Wiley, pp. 167-185.
- Seppala M., Riittinen L., Julkunen M., Koistinen R., Wahlstrom T., Iino K., et al. (1988). Structural studies, localization in tissue and clinical aspects of human endometrial proteins. J Reproduct Fertil 36:127-141.
- Shiu RP, Iwasiow BM (1985). Prolactin-inducible proteins in human breast cancer cells. J Biol Chem 260:11307-11313. Singer AG, Macrides F. (1990). Aphrodisin: pheromone or transducer? Chem Senses 15:199-203.[Abstract/Free Full Text]
- Spielman AI, D'Abundo A., Field RB, Schmale H. (1993). Protein analysis of human von Ebner saliva and a method for its collection from the foliate papillae J Dent Res 72:1331-1335. Swanson PE, Pettinato G., Lillemoe TJ, Wick MR (1991). Gross cystic disease fluid protein-15 in salivary gland tumors. Arch Pathol Lab Med 115:158-163.[Medline]
[Order article via Infotrieve]
- Windass JD, Mullins JJ, Beecroft LJ, George H., Meacock PA, Williams BRG, et al. (1984). Molecular cloning of cDNAs from androgen-independent mRNA species of DBA/2 mouse submaxillary glands. Nucleic Acids Res 12:1361-1376. Yoshida A., Kodama Y., Hatanaka S., Takasaki T., Kuriwaki K., Yoshida H. (1991). Apocrine adenocarcinoma of the bilateral axillae. Acta Pathol Jpn 41:927-932.[Medline]
[Order article via Infotrieve]
- Yoshida A., Hatanaka S., Oneda S., Yoshida H. (1992). Signet ring cells in breast carcinoma: an immunohistochemical and ultrastructural study. Acta Pathol Jpn 42:523-528[Medline]
[Order article via Infotrieve]
Journal of Dental Research, Vol. 74, No. 9,
1543-1550 (1995)
DOI: 10.1177/00220345950740090701

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