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Journal of Dental Research
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Concise Review: Saliva and Growth Factors: The Fountain of Youth Resides in Us All

T. Zelles

Department of Oral Biology, Semmelweis University Medical School, Budapest, Hungary

K.R. Purushotham

Department of Oral Biology, PO Box 100424, University of Florida, Gainesville, FL 32610

S.P. Macauley

Department of Oral Biology, PO Box 100424, University of Florida, Gainesville, FL 32610

G.E. Oxford

Department of Oral Biology, PO Box 100424, University of Florida, Gainesville, FL 32610

M.G. Humphreys-Beher

Department of Oral Biology, PO Box 100424, University of Florida, Gainesville, FL 32610

The predominant focus of research dealing with saliva revolves around the role in the maintenance of oral health through a number of physiological and biological properties of constituent proteins. An ever-expanding literature exists indicating that the salivary glands additionally synthesize, and secrete into saliva, a wide range of growth factors. Animal studies with epidermal growth factor have provided evidence for a role in both oral and systemic health, through the promotion of wound healing rates. Thus, the ability to manipulate their rates of synthesis and absorption from saliva holds the potential to enhance tissue regeneration and homeostasis.

Key Words: salivary glands • epidermal growth factor • saliva • wound healing

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Journal of Dental Research, Vol. 74, No. 12, 1826-1832 (1995)
DOI: 10.1177/00220345950740120301
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