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Change of Salivary IgA Secretion and Caries Development in Irradiated Rats
T. Takei
Department of Pedodontics, Faculty of Dentistry, Osaka University, 1-8 Yamadaoka, Suita, Osaka 565, Japan
W. Aono
Department of Pedodontics, Faculty of Dentistry, Osaka University, 1-8 Yamadaoka, Suita, Osaka 565, Japan, Faculty of Dentistry, Osaka University, 1-8 Yamadaoka, Suita, Osaka 565, Japan
S. Nagashima
Department of Pedodontics
T. Yoshida
Department of Pedodontics, Faculty of Dentistry, Osaka University, 1-8 Yamadaoka, Suita, Osaka 565, Japan
T. Hashida
Oral and Maxillofacial Radiology, Faculty of Dentistry, Osaka University, 1-8 Yamadaoka, Suita, Osaka 565, Japan
S. Sobue
Department of Pedodontics, Faculty of Dentistry, Osaka University, 1-8 Yamadaoka, Suita, Osaka 565, Japan
T. Ooshima
Department of Pedodontics, Faculty of Dentistry, Osaka University, 1-8 Yamadaoka, Suita, Osaka 565, Japan
Xerostomia is a serious side-effect of radiotherapy for head and neck cancer and often enhances caries activity. However, the relationship between caries induction and the IgA level in saliva in rats subjected to irradiation of the salivary glands is unclear. The effect of salivary gland irradiation on salivary function was examined in specific pathogen-free Sprague-Dawley rats infected with or without Streptococcus mutans MT8148R (serotype c). The flow rate of saliva and the protein concentration in saliva were significantly reduced in irradiated rats, regardless of infection of S. mutans. The caries activity was enhanced in these rats, and an irradiation level of 50 Gy significantly increased the caries score. However, longitudinal study indicated that the salivary concentration of IgA reactive with S. mutans whole cells maintained similar or significantly higher levels in irradiated rats, when compared with those of nonirradiated rats. In addition, there was no negative correlation between the caries score and the salivary concentration of IgA reactive with S. mutans. These findings suggest that the secreted IgA against S. mutans may not play a significant role in the caries induction of hyposalivated rats.
Key Words: Dental Caries • Immunoglobulins • Rats • Saliva • Xerostomia.
REFERENCES
- Alvares O. (1978). The effects of protein malnutrition on monkey parotid saliva. In: Saliva and dental caries. Sp. Supp. Microbiol Abst. Kleinberg I, Ellison SA, Mandel ID, editors. New York and London: Information Retrieval, Inc., pp. 123-136.
- Anderson RE (1976). Ionizing radiation and the immune response. In: Advances in immunology. Vol. 24. Dixon FJ, Kunkel HG, editors. New York, San Francisco, and London: Academic Press, pp. 215-267.
- Brown LR, Dreizen S., Daly TE, Drane JB, Handler S., Riggan L., et al. (1978). Interrelations of oral microorganisms, immunoglobulins, and dental caries following radiotherapy. J Dent Res 57:882-893.
- Brown LR, Dreizen S., Rider LJ, Johnston DA (1976). The effect of radiation-induced xerostomia on saliva and serum lysozyme and immunoglobulin levels. Oral Surg 41: 83-92.
- Cole MF, Arnold RR, Rhodes MJ, McGhee JR (1977). Immune dysfunction and dental caries. A preliminary report. J Dent Res 56:198-204.
- Crawford JM, Taubman MA, Smith DJ (1975). Minor salivary glands as a major source of secretary immunoglobulin A in the human oral cavity. Science 190:1206-1208.[Abstract/Free Full Text]
- Dreizen S., Brown LR (1976). Xerostomia and dental caries. In: Microbial aspects of dental caries. Vol. 1. Stiles HM, Loesche WJ, O'Brien TC, editors. Washington, DC: IRL Press, pp. 263-273.
- Dreizen S., Brown LR, Daly TE, Drane JB (1977). Prevention of xerostomia-related dental caries in irradiated cancer patients. J Dent Res 56:99-104.
- Hajishengallis G., Nikolova E., Russell MW (1992). Inhibition of Streptococcus mutans adherence to saliva-coated hydroxyapatite by human secretory immunoglobulin A (S-IgA) antibodies to cell surface protein antigen I/II: Reversal by IgAl protease cleavage. Infect Immun 60:5057-5064.[Abstract/Free Full Text]
- Hirst JA, Dutton RW (1970). Cell component in the immune response. 3. Neonatal thymectomy restoration in culture. Cell Immunol 1:190-195.[Medline]
[Order article via Infotrieve]
- Joyston-Bechal S. (1992). Prevention of dental diseases following radiotherapy and chemotherapy. Int Dent J 42:47-53.[Medline]
[Order article via Infotrieve]
- Karmiol M., Walsh RF (1975). Dental caries after radiotherapy of the oral regions. J Am Dent Assoc 91:838-845.[Abstract]
- Keyes PH (1944). A method of recording and scoring gross carious lesions in the molar teeth of Syrian hamsters. J Dent Res 23:439-444.
- Legler DW, McGhee JR, Lynch DP, Mestecky JF, Schaefer ME, Carson J., et al. (1981). Immunodeficiency disease and dental caries in man. Arch Oral Biol 26:905-910.[CrossRef][Medline]
[Order article via Infotrieve]
- Makinodan T., Friedberg BH, Tolbert MG, Gengozian N. (1959). Relation of secondary antigen injection to time of irradiation on antibody production in mice. J Immunol 83:184-188.[Abstract/Free Full Text]
- Mandel ID, Wortman S. (1976). The salivary secretions in health and disease. Oral Rev 8:25-47.
- Miller JJ, Cole LJ ( 1967). The radiation resistance of long-lived lymphocytes and plasma cells in mouse and rat lymph nodes. J Immunol 98:982-990.[Abstract/Free Full Text]
- Ooshima T., Hashida T., Fuchihata H., Fujiwara T., Yoshida T., Izumitani A. (1990). Effect of experimental hyposalivation on the induction of dental caries in rats infected with Streptococcus mutans. Caries Res 24:446-451.[Medline]
[Order article via Infotrieve]
- Ooshima T., Izumitani A., Sobue S., Hamada S. (1983). Cariostatic effect of palatinose on experimental dental caries in rats. Jpn J Med Sci Biol 36:219-223.[Medline]
[Order article via Infotrieve]
- Ooshima T., Sobue S., Hamada S., Kotani S. (1981). Susceptibility of rats, hamsters, and mice to carious infection by Streptococcus mutans serotype c and d organisms. J Dent Res 60:855-859.
- Reinholdt J., Kilian M. (1987). Interference of IgA protease with the effect of secretory IgA on adherence of oral streptococci to saliva-coated hydroxyapatite. J Dent Res 66:492-497.
- Ritchie JR, Brown JR, Guerra LR, Mason G. (1985). Dental care for the irradiated cancer patient. Quintessence Int 12:837-842.
- Sado T. ( 1969). Functional and ultrastructural studies of antibody-producing cells exposed to 10,000 R in millipore diffusion chambers. Int J Radiat Biol 15:1-22.
- Sodicoff M., Pratt NE, Trepper P., Sholley MM, Hoffenberg S. (1977). Effects of x-irradiation and the resultant inanition on amylase content of the rat parotid gland. Arch Oral Biol 22:261-267.[Medline]
[Order article via Infotrieve]
Journal of Dental Research, Vol. 73, No. 9,
1503-1508 (1994)
DOI: 10.1177/00220345940730090401
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