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Factors Associated with Hepatitis B Vaccine Response Among Dentists

Centers for Disease Control & Prevention, Division of Oral Health, Mailstop F10, 1600 Clifton Road, Atlanta, Georgia 30333

C. Siew

American Dental Association Health Foundation Research Institute

S.A. Lockwood

Centers for Disease Control & Prevention, Division of Oral Health, Mailstop F10, 1600 Clifton Road, Atlanta, Georgia 30333

S.E. Gruninger

American Dental Association Health Foundation Research Institute

S.-B. Chang

American Dental Association Health Foundation Research Institute

E.A. Neidle

School of Dental and Oral Surgery, Columbia University

C.M. Russell

Office of Biostatistics, Medical College of Georgia

The objective of this study was to evaluate personal and immunization factors associated with serologic evidence of hepatitis B virus (HBV) vaccine response. A study was conducted using data from United States dentists participating from 1987 to 1991 in the Health Screening Program of the American Dental Association's annual session. This study included dentists (n = 507) who (1) received their most recent dose of HBV vaccine within the previous 10 months, (2) completed a core questionnaire, and (3) were tested for HBV markers (HBsAg, anti-HBs, and anti-HBc) and were found not to have evidence of past or present infection. Non-responders were defined as dentists testing negative for all three markers (n = 100). Responders were defined as dentists having serological evidence of anti-HBs alone (n = 407). Logistic regression models were used to assess the relationship of vaccine response to the variables sex, age, number of vaccine doses, site of vaccination, type of vaccine, and history of hepatitis. Vaccine response was most strongly associated with sex, age, and number of doses. Factors unrelated to vaccine response included type of vaccine and history of hepatitis. Adherence to the recommended number of doses and early vaccination are critical to adequate protection against hepatitis B infection of dentists, who are often exposed to blood and other body fluids.

Key Words: Antibodies • Dentists • Hepatitis B • Immunity • Vaccine.

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Journal of Dental Research, Vol. 73, No. 5, 1029-1035 (1994)
DOI: 10.1177/00220345940730050301


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Cleveland, J.L. Articles by Russell, C.M. Search for Related Content PubMed PubMed Citation Articles by Cleveland, J.L. Articles by Russell, C.M. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Medline Plus Health Information Hepatitis B Immunization Social Bookmarking                         What's this?