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Increased Condylar Growth after Experimental Relocation of the Glenoid Fossa

Department of Orthodontics, Institute of Dentistry, University of Oulu, Aapistie 2, 90220 Oulu, Finland

T. Kantomaa

Department of Orthodontics, Institute of Dentistry, University of Oulu, Aapistie 2, 90220 Oulu, Finland

M. Tuominen

Department of Orthodontics, Institute of Dentistry, University of Oulu, Aapistie 2, 90220 Oulu, Finland

Attempts to increase mandibular growth by the stimulation of condylar proliferative activity, either experimentally or with functional appliances in humans, have led to controversial results. The aim of this study was to measure changes in proliferative activity in the mandibular condyle after steady experimental posterior relocation of the glenoid fossa in the rabbit without actively interfering with normal masticatory action. The method differed from most previous experimental procedures, which force the mandible anteriorly to simulate functional appliance therapy. Twelve 5-day-old rabbits underwent gluing of the interparietal, temporoparietal, and lambdoidal sutures. Three experimental and three control rabbits were injected with tritiated thymidine at 10, 15, 20, and 30 days and were killed after 2 h for histological and autoradiographic examination. The total number of labeled cells in the prechondroblastic layer was higher in the experimental group, the difference being greatest in the 20-day-old rabbits. The highest proliferative activity in the experimental group was found in the area immediately posterior to the articular contact surface. There was a tendency for the cartilage layers to be thicker in the experimental group, especially in the extreme anterior segments of the condyle.

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Journal of Dental Research, Vol. 72, No. 9, 1356-1359 (1993)
DOI: 10.1177/00220345930720091701


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Pirttiniemi, P. Articles by Tuominen, M. Search for Related Content PubMed PubMed Citation Articles by Pirttiniemi, P. Articles by Tuominen, M. Pubmed/NCBI databases Medline Plus Health Information Head and Brain Malformations Social Bookmarking                         What's this?