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Journal of Dental Research
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Delivery of Antiplaque Agents from Dentifrices, Gels, and Mouthwashes

D. Cummins

Unilever Dental Research, Port Sunlight Laboratory, Quarry Road East, Bebington, Wirral L63 3JW, England

J.E. Creeth

Unilever Dental Research, Port Sunlight Laboratory, Quarry Road East, Bebington, Wirral L63 3JW, England

Antiplaque agents delivered from toothpastes, gels, or mouthrinses can augment mechanical oral hygiene procedures to control the formation of supragingival plaque and the development of early periodontal disease. Clinically effective antiplaque agents are characterized by a combination of intrinsic antibacterial activity and good oral retention properties.

The overall oral retention of an antiplaque agent is determined by the strength and rate of association of the agent with its receptor sites and the accessibility of these sites. The substantivity of an antiplaque agent and its clearance from the oral cavity are determined by the rate of dissociation of the agent from the receptor sites and the salivary composition and flow rate. Positively charged and non-charged organic molecules, metal ions, enzymes, and surface-active agents have all been considered as antiplaque agents. To exert clinical antiplaque activity, an antimicrobial agent must be formulated in a chemically compatible delivery vehicle to give optimal release and uptake to the sites of action in a biologically active form during its time of application.

In principle, antiplaque activity may be enhanced by combining antimicrobial agents with broadly similar, but complementary, modes of action. Alternatively, the activity of a single agent may be increased by use of a retention aid to enhance oral substantivity. Substantial evidence exists to demonstrate the validity of the first approach. However, there are few data, as yet, to support the effectiveness of the second.

The oral mucosa is the bulk retention site for all clinically proven antiplaque agents. Plaque, the pellicle-coated tooth surface, and saliva are probably all sites of biological action. A detailed understanding of the interactions between agents and the various receptor sites, and of the importance of these receptor sites to biological activity, is generally lacking.

REFERENCES

  • Abdellatif HM, Burt BA ( 1987). An epidemiological investigation into the relative importance of age and oral hygiene status as determinants of periodontitis. J Dent Res 66:13-18.[Abstract/Free Full Text]
  • Addy M. ( 1986). Chlorhexidine compared with other locally delivered antimicrobials. J Clin Periodontol 13:951-964.
  • Afflitto J., Fakhry-Smith S., Gaffar A. (1989). Salivary and plaque Triclosan levels after brushing with a 0.3% Triclosan/copolymer/NaF dentifrice. Am J Dent 2 (Spec Iss):207-210.[Medline] [Order article via Infotrieve]
  • Afseth J. (1983). Some aspects of the dynamics of copper and zinc retained in plaque as related to that effect on plaque pH. Scand J Dent Res 91:169-174.[Medline] [Order article via Infotrieve]
  • Afseth J., Helgeland K. (1986). Factors affecting the retention of copper in the human oral cavity after mouthrinses. Scand J Dent Res 99:141-145.
  • Afseth J., Helgeland K., Bonesvoll P. (1983). Retention of copper and zinc in the oral cavity following rinsing with aqueous solutions of copper and zinc salts. Scand J Dent Res 91:42-45.[Medline] [Order article via Infotrieve]
  • Attramadal A., Svatun B. (1984). In vivo antibacterial effect of tin on the oral flora. Scand J Dent Res 92:161-164.[Medline] [Order article via Infotrieve]
  • Attstrom R. (1988). Does supragingival plaque removal prevent further breakdown? In: Guggenheim B, editor. Periodontology today. Basel (Switzerland): Karger, 251-259.
  • Axelsson P., Lindhe J. (1978). Effect of controlled oral procedures on caries and periodontal disease in adults. J Clin Periodontol 14:524-527.[CrossRef]
  • Bonesvoll P.( 1977a). Oral pharmacology of chlorhexidine. J Clin Periodontol 4:49-65.[CrossRef][Medline] [Order article via Infotrieve]
  • Bonesvoll P. (1977b). Influence of ionic strength, calcium, sodium dodecyl sulphate and urea on the retention of chlorhexidine in the human mouth after mouthrinses. Arch Oral Biol 22:273-279.[CrossRef][Medline] [Order article via Infotrieve]
  • Bonesvoll P. (1978). Retention and plaque inhibiting effect in man of chlorhexidine after multiple mouthrinses and retention and release of chlorhexidine after toothbrushing with a chlorhexidine gel. Arch Oral Biol 23:295-300.[CrossRef][Medline] [Order article via Infotrieve]
  • Bonesvoll P., Gjermo P. (1978). A comparison between chlorhexidine and some quaternary ammonium compounds with regard to retention, salivary concentrations and plaque-inhibiting effect in the human oral cavity after mouthrinses. Arch Oral Biol 23:289-294.[CrossRef][Medline] [Order article via Infotrieve]
  • Bonesvoll P., Lokken P., Rølla G. (1974a). Influence of concentration time, temperature and pH on the retention of chlorhexidine in the oral cavity after mouthrinses. Arch Oral Biol 19:1025-1029.[CrossRef][Medline] [Order article via Infotrieve]
  • Bonesvoll P., Lokken P., Rølla G., Pans PN ( 1974b). Retention of chlorhexidine in the human oral cavity after mouthrinses. Arch Oral Biol 19:209-212.[CrossRef][Medline] [Order article via Infotrieve]
  • Bonesvoll P., Olsen I. (1974). Influence of teeth, plaque and dentures on the retention of chlorhexidine in the human oral cavity. J Clin Periodontol 1:214-221.[CrossRef][Medline] [Order article via Infotrieve]
  • Ciancio SG (1989). Adjunctive uses of topical antimicrobial mouthrinses. Am J Dent 2 (Spec Iss):299-302.[Medline] [Order article via Infotrieve]
  • Clerehugh V., Worthington H., Clarkson J., Davies Tgh (1989). The effectiveness of two test dentifrices on dental plaque formation: a 1-week clinical study. Am J Dent 2 (Spec Iss):221-224.[Medline] [Order article via Infotrieve]
  • Cummins D. (1991a). Routes to chemical plaque control. Biofouling 4:199-207.[CrossRef]
  • Cummins D. (1991b). Zinc citrate/Triclosan: a new antiplaque system for the control of plaque and the prevention of gingivitis: short term clinical and mode of action studies. J Clin Periodontol 18:455-461.[CrossRef][Medline] [Order article via Infotrieve]
  • Cummins D. (1992). Mechanism of action of clinically proven antiplaque agents. In: Embery G, Rølla G, editors. Clinical and biological aspects of dentifrices. Oxford (England): Oxford University Press, Chapter 18, 205-228.
  • Cummins D., Watson GK (1989). Computer model relating chemistry to biological activity of metal antiplaque agents. J Dent Res 68 (Spec Iss):1702-1705.
  • Dawes C. (1983). A mathematical model of salivary clearance of sugar from the oral cavity. Caries Res 17:321-334.[Medline] [Order article via Infotrieve]
  • De Salva SJ, Kong BM, Lin Y-K.( 1989). Triclosan: a safety profile. Am JDent 2 (Spec Iss):185-196.
  • Gilbert RJ (1987). The oral clearance of zinc and Triclosan from a dentifrice. J Pharm Pharmacol 39:480-483.[Medline] [Order article via Infotrieve]
  • Gilbert RJ, Baehni P. (1986). Uptake and desorption of Triclosan and zinc by gingival tissue (abstract). J Dent Res 65:787.
  • Gilbert RJ, Ingram GS (1988). The oral disposition of zinc following the use of an anticalculus toothpaste containing 0.5% zinc citrate. J Pharm Pharmacol 40:399-402.[Medline] [Order article via Infotrieve]
  • Gilbert RJ, Tan Walker Rlb, van der Ouderaa Fjg (1989). Delivery of zinc and Triclosan to micro-reservoirs of antibacterial activity. J Dent Res 68:1706-1707.
  • Gilbert RJ, Watson GK (1986). The tooth surface as a reservoir of antimicrobial activity (abstract). J Dent Res 65:817.
  • Gilbert RJ, Williams Peo (1987). The oral retention and antiplaque efficacy of Triclosan in human volunteers. Br Clin Pharmacol 23:579-583. Gjermo P. (1989). Chlorhexidine and related compounds. J Dent Res 68 (Spec Iss):1602-1608.
  • Gjermo P., Baastad KL, Rølla G. (1970). The plaque-inhibiting capacity of 11 antibacterial compounds. J Periodont Res 5:102-109.[CrossRef][Medline] [Order article via Infotrieve]
  • Gjermo P., Bonesvoll P., Rølla G. (1974). Relationship between plaque-inhibiting effect and retention of chlorhexidine in the human oral cavity. Arch Oral Biol 19:1031-1034.[CrossRef][Medline] [Order article via Infotrieve]
  • Gjermo P., Bonesvoll P., Hjeljord LG, Rølla G. (1975). Influence of variation of pH of chlorhexidine mouthrinses on oral retention and plaque inhibiting effect. Caries Res 9:74-82.[Medline] [Order article via Infotrieve]
  • Gjermo P., Saxton CA (1991). Antibacterial dentifrices: clinical data with emphasis on zinc/Triclosan. J Clin Periodontol 18:468-473.[CrossRef][Medline] [Order article via Infotrieve]
  • Goodson JM (1989). Pharmacokinetic principles controlling efficacy of oral therapy. J Dent Res 68 (Spec Iss): 1625-1632.
  • Hjeljord LG, R0lla G., Bonesvoll P. (1973). Chlorhexidine protein interactions. J Periodont Res 8 (12 Suppl):11-16.[Medline] [Order article via Infotrieve]
  • Jenkins S., Addy M., Newcombe R. (1989). Toothpastes containing 0.3% and 0.5% Triclosan. 1. Effects on 4 day plaque regrowth. Am J Dent 2 (Spec Iss):211-214.[Medline] [Order article via Infotrieve]
  • Jenkins S., Addy M., Wade WO ( 1988). The mechanism of action of chlorhexidine. A study of plaque growth on enamel inserts, in vivo. J Clin Periodontol 15:415-424.[CrossRef][Medline] [Order article via Infotrieve]
  • Johansen JR, Gjermo P., Eriksen HN (1975). Effect of 2 years' use of chlorhexidine-containing dentifrices on plaque, gingivitis and caries. Scand J Dent Res 83:288-292.[Medline] [Order article via Infotrieve]
  • Jones CL, Stephen KW, Ritchie JA, Huntington E., Saxton CA, van der Ouderaa Fjg (1988). Long term exposure of plaque to zinc citrate. Caries Res 22:84-90.[Medline] [Order article via Infotrieve]
  • Kornman KS (1986). Antimicrobial agents. In: Löe H, Kleinman D, editors. Dental plaque control measures and oral hygiene practices. Oxford (England): IRL Press, 121-142.
  • Lane RM, Hull Dmc, Saxton CA, van der Ouderaa Fjg (1985). Dentifrice composition. European Patent Appl. 85 303216.7.
  • LeComte P., Dawes C. (1987). The influence of salivary flow rate on the diffusion of potassium chloride from artificial plaque at different sites in the mouth. J Dent Res 66:1614-1618.[Abstract/Free Full Text]
  • Lindhe J., Nyman S. (1975). The effect of plaque control and surgical pocket elimination on the establishment and maintenance of periodontal health. A longitudinal study of periodontal therapy in cases of advanced disease. J Clin Periodontol 2:67-69.[CrossRef][Medline] [Order article via Infotrieve]
  • Mandel ID (1988). Chemotherapeutic agents for controlling plaque and gingivitis. J Clin Periodontol 15:488-498.[CrossRef][Medline] [Order article via Infotrieve]
  • Marsh PD (1991). Dentifrices containing new agents for the control of plaque and gingivitis: microbiological aspects. J Clin Periodontol 18:462-467.[CrossRef][Medline] [Order article via Infotrieve]
  • Moran J., Addy M. ( 1984). The effect of surface adsorption and staining reactions on the antimicrobial properties of some cationic antiseptic mouthwashes. J Periodontol 55:278-282.[Medline] [Order article via Infotrieve]
  • Nabi N., Mukerjee C., Schmid R., Gaffar A. (1989). In vitro and in vivo studies on Triclosan/PVM/MA copolymer/NaF combination as an antiplaque agent. Am J Dent 2 (Spec Iss):197-206.[Medline] [Order article via Infotrieve]
  • Newman HN (1986). Modes of application of antiplaque chemicals. J Clin Periodontol 13:965-975.[CrossRef][Medline] [Order article via Infotrieve]
  • Oppermann RV (1980). The effect of organic and inorganic ions on the acidogenicity of dental plaque in vivo (thesis). Oslo (Norway): Dental Faculty, University of Oslo, 1-53.
  • Pader M. (1988). Oral hygiene products and practice. 1sted. New York: Dekker, 9-20.
  • Roberts WR, Addy M. ( 1981). Comparison of the in vivo and in vitro antibacterial properties of antiseptic mouthrinses containing chlorhexidine alexidine, cetylpyridinium chloride and hexetidine. J Clin Periodontol 8:295-310.[CrossRef][Medline] [Order article via Infotrieve]
  • Rølla G., Melsen B. (1975). On the mechanism of plaque inhibition by chlorhexidine. J Dent Res 54 (Spec Iss):B57-B62.[Free Full Text]
  • Saxton CA (1986). The effects of a dentifrice containing zinc citrate and 2,4,4' trichloro-2'-dihydroxydiphenyl ether. J Periodontol 57:555-556.[Medline] [Order article via Infotrieve]
  • Saxton CA, Cummins D. (1989). The effect of zinc citrate dentifrices on the development of gingivitis (abstract). J Dent Res 68:971.
  • Saxton CA, Harrap GJ, Lloyd AM (1986). The effect of dentifrices containing zinc citrate on plaque growth and oral zinc levels. J Clin Periodontol 13:301-306.[CrossRef][Medline] [Order article via Infotrieve]
  • Saxton CA, Svatun B., Lloyd AM (1988). The antiplaque effects and mode of action of combinations of zinc citrate and a nonionic antimicrobial agent. Scand J Dent Res 96:212-217.[Medline] [Order article via Infotrieve]
  • Scheie AAa (1989). Modes of action of currently known chemical antiplaque agents other than chlorhexidine. J Dent Res 68 (Spec Iss):1609-1618.
  • Scheie AAa, Assev S., Rølla G. (1985). The effect of SnF2 and NaF on glucose uptake and metabolism in S. mutans OMZ 176. In: Leach SA, editor. Factors relating to demineralisation and remineralisation of teeth. Oxford (England): IRL Press, 99-104.
  • Scheie AAa, Assev S., Rølla G. (1988). Combined effect of xylitol, NaF and ZnCl2 on growth and metabolism of Streptococcus sobrinus OMZ 176. APMIS 96:761-767.[Medline] [Order article via Infotrieve]
  • Senior N. (1972). Some observations on the formulation and properties of chlorhexidine. J Soc Cosmet Chem 11:1-19.
  • Singh SM, Rustogi KN, Volpe AR, Petrone M., Kirkup R., Collins M. (1989). Effect of a dentifrice containing Triclosan and a copolymer on plaque formation: A 6-week clinical study. Am J Dent 2(Spec Iss): 225-230.[Medline] [Order article via Infotrieve]
  • Sjoblöm M., Ainamo A., Ainamo J. (1976). Antimicrobial effect of four different toothpastes. Scand J Dent Res 84:377-380.[Medline] [Order article via Infotrieve]
  • Southard GL, Boulware RT, Walborn DR, Groznic WJ, Senior SL, Yankell SL (1984). Sanguinarine-a new antiplaque agent. Am J Dent (Suppl) 5:572-575.
  • Stephen KW, Saxton CA, Jones CL, Ritchie JA, Morrison T. (1990). Control of gingivitis and calculus by a dentifrice containing a zinc salt and Triclosan. J Periodont Res 61:674-679.
  • Svatun B. (1981). Effect on plaque formation and gingival conditions of self-performed toothbrushing with a stannous fluoride/stannous pyrophosphate dentifrice. In: Rølla G, Sonju T, Embery G, editors. Tooth surface interactions and preventive dentistry. London (England): IRL Press, 33-37.
  • Svatun B., Saxton CA, Rølla G. (1990). Six month study of the effect of a dentifrice containing zinc citrate and Triclosan on plaque, gingival health and calculus. Scand J Dent Res 98:301-304.[Medline] [Order article via Infotrieve]
  • Tan Walker Rlb, Gilbert RJ (1989). Oral delivery of zinc from slurries and separated supernatant fractions of dentifrices. J Dent Res 68 (Spec Iss):1708-1709.
  • van der Ouderaa Fjg (1991). Antiplaque agents-rationale and prospects for prevention of early gum disease. J Clin Periodontol 18:447-454.[CrossRef][Medline] [Order article via Infotrieve]
  • van der Ouderaa Fjg (1992). Clinically proven antiplaque agents. In: Embery G, Rølla G, editors. Clinical and biological aspects of dentifrices. Oxford (England): Oxford University Press, Chapter 17, 181-204.
  • van der Ouderaa Fjg, Cummins D. (1989). Delivery systems for agents for supra- and sub-gingival plaque control. J Dent Res 68 (Spec Iss):1617-1624.
  • van der Ouderaa Fjg, Cummins D. 1991). Anti-plaque dentifrices: current status and prospects. Int Dent J 41:117-123.[Medline] [Order article via Infotrieve]
  • van Ginneken Cam (1977). Kinetics of drug-receptor interaction. In: van RossumJM, editor. Kinetics of drug action. Berlin (Germany): Springer Verlag, 357-411.
  • Waaler SM (1990). Further in vivo studies on the plaque-inhibiting effect of chlorhexidine and its binding mechanisms. Scand J Dent Res 98:422-427.[Medline] [Order article via Infotrieve]
  • Waaler SM, Rølla G. (1983). Effect of chlorhexidine and lanthanum on plaque formation. Scand J Dent Res 91:260-262.[Medline] [Order article via Infotrieve]
  • Wagner JG (1975). Fundamentals of clinical pharmacokinetics. Illinois: Hamilton Press Inc.

Journal of Dental Research, Vol. 71, No. 7, 1439-1449 (1992)
DOI: 10.1177/00220345920710071601
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