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A Fluoride Dose-response Evaluation in an Anticaries Clinical Trial

J-212 JHMHC, Division of Biostatistics, Department of Statistics, University of Florida, Gainesville, FL 32610

R. D'Agostino

Department of Mathematics, Boston University, Boston, MA 02215

J.E. Moorhead

J-212 JHMHC, Division of Biostatistics, Department of Statistics, University of Florida, Gainesville, FL 32610

A.J. Conti

J-404 JHMHC, Department of Community Dentistry, College of Dentistry, University of Florida, Gainesville, FL 32610

L. Cancro

Chesebrough-Pond's Inc., Trumbull, CT 06611

This study evaluated the dose-response relationship between four increasing levels of fluoride from 1000 to 2500 ppm F as sodium monofluorophosphate (MFP) and three-year dental caries increments, as measured by DMFS, DMFT, and DFS-A on 4424 schoolchildren. The results indicated consistent linear decreases in all three dental indices as the dose level increased to 2500 ppm F MFP, with slopes (average reductions) of 0.32 in DMFS for an increase of 1000 ppm F, 0.13 in DMFT, and 0.17 in DFS-A when all children were evaluated, p < 0.03 for each index. For children 11 years and older at baseline, the slopes quadrupled, p < 0.01 for each index. Age and baseline DMFS were shown to be the most important covariates to control for in the statistical models. No differences in adverse reactions, or other safety problems, were observed at the different dose levels.

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Journal of Dental Research, Vol. 71, No. 6, 1286-1291 (1992)
DOI: 10.1177/00220345920710060401


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Marks, R.G. Articles by Cancro, L. Search for Related Content PubMed PubMed Citation Articles by Marks, R.G. Articles by Cancro, L. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Social Bookmarking                         What's this?