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Comparison of Whole Saliva Flow Rates and Mucin Concentrations in Healthy Caucasian Young and Aged Adults
M. Navazesh
Department of Dental Medicine and Public Health
R.A. Mulligan
Department of Dental Medicine and Public Health
V. Kipnis
Department of Preventive Medicine, School of Medicine, University of Southern California, Los Angeles, California 90033
P.A. Denny
Department of Basic Sciences, School of Dentistry, University of Southern California, Los Angeles, California 90089-0641
P.C. Denny
Department of Basic Sciences, School of Dentistry, University of Southern California, Los Angeles, California 90089-0641
Unstimulated and chewing-stimulated whole saliva samples were obtained from 42 healthy Caucasians; 21 were between 18 and 35 years of age, and 21 between 65 and 83 years of age. The unstimulated salivary flow rate was significantly lower in the aged group, but the stimulated flow rate was significantly higher in the aged than in the young group. Both groups showed significantly increased flow during salivary stimulation. MG1 and MG2 concentrations in unstimulated and stimulated saliva samples were significantly lower in the aged group. There were no significant correlations between salivary flow rates and MG1 and MG2 concentrations.
REFERENCES
- Baum BJ ( 1981). Evaluation of stimulated parotid saliva flow rate in different age groups. J Dent Res 60:1292-1296.[Abstract/Free Full Text]
- Ben-Aryeh H., Miron D., Szargel R., Gutman D. (1984). Whole-saliva secretion rates in old and young healthy subjects. J Dent Res 63:1147-1148.[Abstract/Free Full Text]
- Ben-Aryeh H., Shalev A., Szargel R., Laor A., Laufer D., Gutman D. (1986). The salivary flow rate and composition of whole and parotid resting and stimulated saliva in young and old healthy subjects. Biochem Med and Metabolic Biol 36:260-266.[CrossRef]
- Bertram U. (1967). Xerostomia: studies on salivary secretion (Thesis). Acta Odontol Scand 25 (49 suppl):1-126.[Medline]
[Order article via Infotrieve]
- Chauncey HH, Brokan GA, Wayler AH, Feller RP, Kapur KK (1981). Parotid fluid composition in healthy aging males. Adv Physiol Sci 28:323-328.
- Dawes C. (1975). Rhythms in salivary flow rate and composition. Int J Chronobiol 2:253-277.
- Dawes C., Jenkins GN (1964). The effects of different stimuli on the composition of saliva in man. J Physiol (Lond) 170:86-100.[Free Full Text]
- Denny PC, Denny PA, Klauser DK, Hong SH, Navazesh M., Tabak LA (1991). Age-related changes in mucins from human whole saliva. J Dent Res 70:1320-1327.[Abstract/Free Full Text]
- Gandara BK, Izutsu KT, Truelove EL, Ensign WY, Sommers EE (1985). Age-related salivary flow rate changes in controls and patients with oral lichen planus. J Dent Res 64:1149-1151.[Abstract/Free Full Text]
- Gutman D., Ben-Aryeh H. (1974). The influence of age on salivary contents and rate of flow. Int J Oral Surg 3:314-317.[Medline]
[Order article via Infotrieve]
- Heft MH, Baum BJ ( 1984). Unstimulated and stimulated parotid salivary flow rate in individuals of different ages. J Dent Res 63:1182-1185.[Abstract/Free Full Text]
- Kerr AC ( 1961). The physiological regulation of salivary secretion in man. In: International series of monographs on oral biology. Oxford (UK): Pergamon Press, 9.
- Kirk ER ( 1982). Experimental design. 2nd ed. Pacific Grove (CA): Brooks/ Cole Publishing Company, 365-379.
- Mandel ID (1987). The function of saliva. J Dent Res 66:623-627. Navazesh M, Christensen CM (1982). A comparison of whole mouth resting and stimulated salivary measurement procedures. J Dent Res 61:1158-1162.
- Parvinen T., Larmas M. (1982). Age dependency of stimulated salivary flow rate, pH, and lactobacillus and yeast concentrations. J Dent Res 61:1052-1055.[Abstract/Free Full Text]
- Pedersen W., Schubert M., Izutsu K., Mersai T., Truelove EL (1985). Age-dependent decreases in human submandibular gland flow rates as measured under resting and post-stimulation conditions. J Dent Res 64:822-825.[Abstract/Free Full Text]
- Persson RE, Izutsu KT, Truelove EL, Persson R. (1991). Differences in salivary flow rates in elderly subjects using xerostomatic medications. Oral Surg Oral Med Oral Pathol 72:42-46.[CrossRef][Medline]
[Order article via Infotrieve]
- Scott J. (1975). Age, Sex and Contralateral Differences in the volume of human submandibular salivary glands. Arch Oral Biol 20:885-887.[CrossRef][Medline]
[Order article via Infotrieve]
- Scott J. (1977). Quantitative age changes in the histological structure of human submandibular salivary glands. Arch Oral Biol 22:221-227.[CrossRef][Medline]
[Order article via Infotrieve]
- Scott J. (1979). The proportional volume of mucous acinar cells in normal human submandibular salivary glands. Arch Oral Biol 24:479-481.[CrossRef][Medline]
[Order article via Infotrieve]
- Tabak LA Levine MJ, Mandel ID, Ellison SA (1982). Role of salivary mucins in the protection of the oral cavity. J Oral Pathol 11:1-17.[Medline]
[Order article via Infotrieve]
- Tylenda CA, Ship JA, Fox PC, Baum BJ ( 1988). Evaluation of submandibular salivary flow rate in different age groups. J Dent Res 67:1225-1228.[Abstract/Free Full Text]
- Waterhouse JP, Chisholm DM, Winter RB, Patel M., Yale RS ( 1973). Replacement of functional parenchymal cells by fat and connective tissue in human submandibular salivary glands. An age-related study. J Oral Pathol 2:16-27.[CrossRef][Medline]
[Order article via Infotrieve]
- Woolson RF (1987). Statistical methods for the analysis of biomedical data. New York (NY): John Wiley and Sons, 106-114.
- Yaegaki K., Ogura R., Kameyama T., Sujaku L. (1985). Biochemical diagnosis of reduced salivary gland function. Int J Oral Surg 14:47-49.[CrossRef][Medline]
[Order article via Infotrieve]
Journal of Dental Research, Vol. 71, No. 6,
1275-1278 (1992)
DOI: 10.1177/00220345920710060201

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