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Effect of Age on Immunoglobulin Content and Volume of Human Labial Gland Saliva

Department of Immunology, Forsyth Dental Center, 140 The Fenway, Boston, Massachusetts 02115

K. Joshipura

Department of Biostatistics, Forsyth Dental Center, 140 The Fenway, Boston, Massachusetts 02115

R. Kent

Department of Biostatistics, Forsyth Dental Center, 140 The Fenway, Boston, Massachusetts 02115

M.A. Taubman

Department of Immunology, Forsyth Dental Center, 140 The Fenway, Boston, Massachusetts 02115

Stimulated lower labial (LLGF) and parotid salivary volumes and IgG, IgA, and IgM concentrations were measured in 264 subjects whose ages ranged from 17 to 76 years. A significant (p <0.001) age-related decline in LLGF output was observed for subjects over this age range. Sixty-three percent of the subjects in the 18-20-year-old group (n = 46) secreted at least 10 µL of labial saliva in a 7- 10-minute period, while approximately 70% of the subjects in the two oldest groups (61-70 and 71-76 years old) secreted less than 1 µL of LLGF during this time period (n = 64). No significant gender-based differences occurred in the volumes of labial saliva secreted. Stimulated parotid salivary flow showed no age-related trend in these subjects. Lower labial gland salivary IgA concentrations in an older population (mean age ± SD = 55.6 yr ± 1.3) were significantly lower (p < 0.025) than IgA concentrations in a younger population (20.7 yr ±0.8), when IgA was expressed as µg/mL LLGF collected. Immunoglobulin A concentrations in parotid saliva and IgG and IgM concentrations in labial and parotid saliva were not significantly different when the two age populations were compared. These data suggest that the physiological and immunological potential of labial gland saliva may decrease with age.

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Journal of Dental Research, Vol. 71, No. 12, 1891-1894 (1992)
DOI: 10.1177/00220345920710120701


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Smith, D.J. Articles by Taubman, M.A. Search for Related Content PubMed PubMed Citation Articles by Smith, D.J. Articles by Taubman, M.A. Pubmed/NCBI databases Substance via MeSH Medline Plus Health Information Seniors' Health Social Bookmarking                         What's this?