|
Sign In to gain access to subscriptions and/or personal tools.
|
Factors Affecting Blood Mercury Concentrations in Practicing Dentists
S.-B. Chang
Department of Toxicology, Research Institute, American Dental Association, 211 East Chicago Avenue, Chicago, Illinois 60611
C. Siew
Department of Toxicology, Research Institute, American Dental Association, 211 East Chicago Avenue, Chicago, Illinois 60611
S.E. Gruninger
Department of Toxicology, Research Institute, American Dental Association, 211 East Chicago Avenue, Chicago, Illinois 60611
It has been suggested that mercury vapor may be transformed into highly toxic organomercury compounds by micro-organisms in the oral cavity and gastrointestinal tract. If this hypothesis is correct, practicing dentists might be expected to have concentrations of organic mercury in their blood higher than that found in non-dentists. Blood mercury concentrations of practicing dentists and non-dentists were determined by means of cold-vapor atomic absorption spectrophotometry. Potential sources of mercury exposure were identified in both dentists and non-dentists through a questionnaire completed at the time of sampling. Concentrations of total and inorganic blood mercury were significantly higher in dentists than in non-dentists. The organomercury concentrations of the two groups were not statistically different (p 0.05). The high concentration of inorganic mercury in the blood of dentists was not related to the organomercury level, suggesting that biotransformation of inorganic mercury to organomercury does not occur in vivo. However, the concentration of blood organomercury was positively correlated with the frequency of fish consumption. There was no correlation between the number of amalgam restorations and the concentration of inorganic blood mercury for both groups. Accidental mercury spills in the dental operatory may contribute most to the concentration of inorganic blood mercury in the blood of dentists.
REFERENCES
- Ada (1983): Safety in the Dental Office. In: Dentist's Desk Reference: Materials, Instruments and Equipment, 2nd ed., Chicago: ADA, pp. 23-50.
- Ahlqwist, M.; Bengtsson, C.; Furunes, B.; Hollender, L.; and Lapidus, L. (1988): Number of Amalgam Tooth Fillings in Relation to Subjectively Experienced Symptoms in a Study of Swedish Women, Community Dent Oral Epidemiol 16:227-231.[CrossRef][Medline]
[Order article via Infotrieve]
- Bauer, J.G. and First, H.A. (1982): The Toxicity of Mercury in Dental Amalgam, CA Dent Assoc J 10:47-61.
- Berglund, A. (1990): Estimation by a 24-hour Study of the Daily Dose of Intra-oral Mercury Vapor Inhaled after Release from Dental Amalgam, J Dent Res 69:1646-1651.[Abstract/Free Full Text]
- Berglund, A.; Pohl, L.; Olsson, S.; and Bergman, M. (1988): Determination of the Rate of Release of Intra-oral Mercury Vapor from Amalgam, J Dent Res 67:1235-1242.[Abstract/Free Full Text]
- Bernard, S.R. and Purdue, P. (1984): Metabolic Model for Methyl and Inorganic Mercury, Health Phys 46:695-699.[Medline]
[Order article via Infotrieve]
- Birke, G.; Johnels, A.G.; Plantin, L.-O.; Sjostrand, B.; Skerfving, S.; and Westermark, T. (1972): Studies on Humans Exposed to Methyl Mercury Through Fish Consumption, Arch Environ Health 25:77-91.[Medline]
[Order article via Infotrieve]
- Butler, G.C. (1978): Exposure to Mercury. In: Trace Metal- Exposure and Health Effect, E. Di Ferrante, Ed., New York: Pergamon Press, pp. 65-72.
- Chang, S.-B.; Siew, C.; and Gruninger, S.E. (1987): Examination of Blood Mercurials in Practicing Dentists Using CVAAS, J Anal Toxicol 11:149-153.[Medline]
[Order article via Infotrieve]
- Cherian, M.G.; Hursh, J.B.; Clarkson, T.W.; and Allen, J. (1978): Radioactive Mercury Distribution in Biological Fluids and Excretion in Human Subjects after Inhalation of Mercury Vapor, Arch Enairon Health 33:109-114.
- Clarkson, T.W. (1976): Quantitative Measures of the Toxicity of Mercury in Man. In: Trace Elements in Human Health and Disease, Vol. 2, A.S. Prasad, Ed., New York: Academic Press, pp. 453-475.
- Clarkson, T.W.; Hursh, J.B.; Sager, P.R.; and Syversen, T.L.M. (1988): Mercury. In: Biological Monitoring of Toxic Metals, T.W. Clarkson, L. Friberg, G.F. Nordberg, and P.R. Sager, Eds., New York: Plenum Press, pp. 199-264.
- Dales, L.G. (1972): The Neurotoxicity of Alkyl Mercury Compounds, Am J Med 53:219-232.[CrossRef][Medline]
[Order article via Infotrieve]
- Enwonwu, C.O. (1987): Potential Health Hazard of Use of Hg in Dentistry: Critical Review of the Literature, Environ Res 42:257-274.[Medline]
[Order article via Infotrieve]
- Friberg, L.; Kullman, L.; Lind, B.; and Nylander, M. (1986): Mercury in the Central Nervous System Correlated to Dental Amalgam Fillings, Lakartidningen 83:519-522.[Medline]
[Order article via Infotrieve]
- Friberg, L.B. and Nylander, M. (1988): Preliminary Studies on Methyl Mercury Biotransformation and Clearance in the Brain of Primates. II. Demethylation of Mercury in Brain, J Trace Elem Exp Med 1:49-56.
- Fung, Y.K.; Molvar, M.P.; Strom, A.; Schneider, N.R.; and Carlson, M.P. (1990): In vivo Mercury and Methyl Mercury Levels in Patients with Amalgam Restorations, Gen Dent 38:36-38.[Medline]
[Order article via Infotrieve]
- Gelbier, S. and Ingram, J. (1989): Possible Phytotoxic Effect of Hg Vapor: a Case Report, Public Health 103:35-40.[CrossRef][Medline]
[Order article via Infotrieve]
- Guyton, A.C. (1986): Textbook of Medical Physiology, 7th ed., Philadelphia: W.B. Saunders Co., p. 207.
- Heintze, U.; Edwardsson, S.; Derand, T.; and Birkhed, D. (1983): Methylation of Mercury from Dental Amalgam and Mercuric Chloride by Oral Streptococci in vitro, Scand J Dent Res 91:150-152.[Medline]
[Order article via Infotrieve]
- Hursh, J.B.; Clarkson, T.W.; Cherian, M.G.; Vostal, J.J.; and Mallie, R.V. (1976): Clearance of Mercury (Hg-197, Hg-203) Vapor Inhaled by Human Subjects, Arch Environ Health 31:302-309.[Medline]
[Order article via Infotrieve]
- Kudsk, F.N. (1973): Biological Oxidation Elemental Mercury. In: Mercury, Mercurials and Mercaptans, M.W. Miller and T.W. Clarkson, Eds., Springfield, IL: Thomas, pp. 355-372.
- Langan, D.C.; Fan, P.L.; and Hoos, A.A. (1987): The Use of Mercury in Dentistry: a Critical Review of the Recent Literature, J Am Dent Assoc 115:867-880.[Medline]
[Order article via Infotrieve]
- Mackert, J.R., Jr. (1987): Factors Affecting Estimation of Dental Amalgam Mercury Exposure from Measurement of Mercury Vapor Levels in Intra-oral and Expired Air, J Dent Res 66:1775-1780.[Abstract/Free Full Text]
- Magos, L.; Halbach, S.; and Clarkson, T.W. (1977): The Role of Catalase in the Oxidation of Mercury Vapor, Biochem Pharmacol 27:1373-1377.[CrossRef]
- Matsuo, N.; Suzuki, T.; and Akagi, H. (1989): Mercury Concentration in Organs of Contemporary Japanese, Arch Environ Health 44:298-303.[Medline]
[Order article via Infotrieve]
- Molin, M. (1990): Mercury Release from Dental Amalgam in Man, Swed Dent J 71 (Suppl): 1-73.
- Moller-Madsen, B.; Hansen, J.C.; and Kragstrup, J. (1988): Mercury Concentrations in Blood from Danish Dentists, Scand J Dent Res 96:56-59.[Medline]
[Order article via Infotrieve]
- Naleway, C.; Sakaguchi, R.; Mitchell, E.; Muller, T.; Ayer, W.A.; and Hefferren, J.J. (1985): Urinary Mercury Levels in US Dentists, 1975-1983: Review of Health Assessment Program, J Am Dent Assoc 111:37-42.[Medline]
[Order article via Infotrieve]
- Nylander, M.;Friberg, L.; Eggleston, D.; and Bjorkman, ( 1989): Mercury Accumulation in Tissues from Dental Staff and Controls in Relation to Exposure, Swed Dent J 13:235-243.[Medline]
[Order article via Infotrieve]
- Nylander, M.; Friberg, L.; and Lind, B. (1987): Mercury Concentrations in the Human Brain and Kidneys in Relation to Exposure from Dental Amalgam Fillings, Swed Dent J 11:179-187.[Medline]
[Order article via Infotrieve]
- Olsson, S. and Bergman, M. (1987): Letter to the Editor, J Dent Res 66:1288-1289.[Free Full Text]
- Olstad, M.L.; Holland, R.I.; andHensten Pettersen, A.H. (1990): Effect of Placement of Amalgam Restorations on Urinary Mercury Concentration, J Dent Res 69:1607-1609.[Abstract/Free Full Text]
- Rowland, I.R.; Grasso, P.; and Davies, M.J. (1975): The Methylation of Mercuric Chloride by Human Intestinal Bacteria, Experientia 31:1064-1065.[CrossRef][Medline]
[Order article via Infotrieve]
- Siew, C.; Chang, S.-B.; and Gruninger, S.E. (1987): Organomercury, Additional Threat?, CA Dent Assoc J 15:18-21.
- Snapp, K.R.; Boyer, D.B.; Peterson, L.C.; and Svare, C.W. (1989): The Contribution of Dental Amalgam to Mercury in Blood, J Dent Res 68:780-785.[Abstract/Free Full Text]
- Svare, C.W.; Peterson, L.C.; Reinhardt, J.W.; Boyer, D.B.; Frank, C.W.; Gay, D.D.; and Cox, R.D. (1981): The Effects of Dental Amalgams on Mercury Levels in Expired Air, J Dent Res 60:1668-1671.[Abstract/Free Full Text]
- Tejning, S. and Ohman, H. (1966): Uptake and Retention of Metallic Mercury in Chlor-Alkali Workers. In: Proceedings of the 15th International Congress on Occupational Health, Vienna: Verlag der Wiener Medizinischen Akademie, pp. 239-242.
- US Department of Commerce (1978): Report on the Chance that US Seafood Consumers Exceed the Current Acceptable Daily Intake for Mercury and Recommended Regulatory Controls, Washington, DC: US Department of Commerce, pp. 1-30.
- US Environmental Protection Agency (EPA) ( 1984): Mercury Health Effects Update-Final Report, EPA-600/8-84-019F.
- Uthe, J.F.; Solomon, J.; and Grift, B. (1972): Rapid Semimicro Method for the Determination of Methyl Mercury in Fish Tissue, JAssoc Official Agricultural Chemists 55:583-589.
- Vander, A.J.; Sherman, J.H.; and Luciano, D.S. (1985): Human Physiology, 4th ed., New York: McGraw-Hill, p. 303.
- Venugopal, B. and Luckey, T.D. (1977): Metal Toxicity in Mammals, Vol. 2, New York: Plenum Press, p. 91.
- Vimy, M.J. and Lorscheider, F.L. (1985a): Intra-oral Air Mercury Released from Dental Amalgam, J Dent Res 64:1069-1071.[Abstract/Free Full Text]
- Vimy, M.J. and Lorscheider, F.L. (1985b): Serial Measurements of Intra-oral Air Mercury: Estimation of Daily Dose from Dental Amalgam, J Dent Res 64:1072-1075.[Abstract/Free Full Text]
- Vimy, M.J.; Luft, A.J.; and Lorscheider, F.L. (1986): Estimation of Mercury Body Burden from Dental Amalgam: Computer Simulation of a Metabolic Compartmental Model, J Dent Res 65:1415-1419.[Abstract/Free Full Text]
- Weiner, I.M.; Levy, R.I.; and Mudge, G.H. (1962): Studies on Mercurial Diuresis: Renal Excretion, Acid Stability and Structure-Activity Relationship of Organic Mercurials, J Pharmacol Exp Ther 138:99-104.
- Who (1976): Environmental Health Criteria I-Mercury, Geneva: World Health Organization.
Journal of Dental Research, Vol. 71, No. 1,
66-74 (1992)
DOI: 10.1177/00220345920710011101

CiteULike Complore Connotea Del.icio.us Digg Reddit Technorati Twitter What's this?
This article has been cited by other articles:

|
 |

|
 |
 
A. Kingman, T. Albertini, and L.J. Brown
Mercury Concentrations in Urine and Whole Blood Associated with Amalgam Exposure in a US Military Population
Journal of Dental Research,
March 1, 1998;
77(3):
461 - 471.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
H.A. Lyttle and G.H. Bowden
The Level of Mercury in Human Dental Plaque and Interaction in vitro between Biofilms of Streptococcus mutans and Dental Amalgam
Journal of Dental Research,
September 1, 1993;
72(9):
1320 - 1324.
[Abstract]
[PDF]
|
 |
|
|
|