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Upper Central Incisor and Canine Tooth Crown Size in 47,XXY Males

Institute of Dentistry, University of Oulu, Aapistie 3, SF-90220 Oulu, Finland

E. Tammisalo

Institute of Dentistry, University of Turku, Lemminkäisenkatu 2, SF-20520 Turku, Finland

G. Townsend

Department of Dentistry, The University of Adelaide, G.P.O. Box 498, Adelaide, South Australia 5001

Enamel and dentin thicknesses were measured in permanent tooth crowns of 47,XXY (Klinefelter syndrome) males. In 47,XXY males, enamel thickness in maxillary central incisors was significantly greater than that in control males or females, and dentin thickness in incisors and canines was significantly greater than that in control females, but smaller than that in normal males. These findings confirm the concept that human dental growth is affected by sex chromosomes. Amelogenesis is promoted by both X and Y chromosome genes, and sexual dimorphism in average tooth size is evidently determined by a promoting effect of the Y chromosome on dentin growth, probably through cell proliferation. This effect can also explain sex predilection for males in the numbers of supernumerary and ordinary teeth.

REFERENCES

• Alvesalo, L. (1971): The Influence of Sex-chromosome Genes on Tooth Size in Man, Proc Finn Dent Soc 67:3-54.
• Alvesalo, L. (1985): Dental Growth in 47,XYY Males and in Conditions with Other Sex-chromosome Anomalies. In: The Y Chromosome, Part B: Clinical Aspects, A.A. Sandberg, Ed., New York: Liss, pp. 277-300.
• Alvesalo, L. and de la Chapelle, A. (1981): Tooth Sizes in Two Males with Deletions of the Long Arm of the Y-chromosome, Ann Hum Genet 45:49-54.[Medline] [Order article via Infotrieve]
• Alvesalo, L. and Kari, M. (1977): Sizes of Deciduous Teeth in 47,XYY Males, Am J Hum Genet 29:486-489.[Medline] [Order article via Infotrieve]
• Alvesalo, L.; Osborne, R.; and Kari, M. (1975): The 47,XYY Males, Y-chromosome and Tooth Size , Am J Hum Genet 27:53-61.[Medline] [Order article via Infotrieve]
• Alvesalo, L. and Portin, P. (1980): The 47,XXY Males, Sex-chromosomes and Tooth Size , Am J Hum Genet 32:955-959.[Medline] [Order article via Infotrieve]
• Alvesalo, L. and Tammisalo, E. (1981): Enamel Thickness in 45,X Females' Permanent Teeth, Am J Hum Genet 33:464-469.[Medline] [Order article via Infotrieve]
• Alvesalo, L.; Tammisalo, E.; and Hakola, P. (1985): Enamel Thickness in 47,XYY Males' Permanent Teeth, Ann Hum Biol 12:421-427.[CrossRef][Medline] [Order article via Infotrieve]
• Alvesalo, L.; Tammisalo, E.; and Therman, E. (1987): 47,XXX Females, Sex Chromosomes and Tooth Crown Structure, Hum Genet 77:345-348.[CrossRef][Medline] [Order article via Infotrieve]
• Alvesalo, L. and Varrela, J. (1980): Permanent Tooth Sizes in 46,XY Females, Am J Hum Genet 32:736-742.[Medline] [Order article via Infotrieve]
• Ferguson-Smith, M.A. (1965): Karyotype-phenotype Correlations in Gonadal Dysgenesis and their Bearing on the Pathogenesis of Malformation, J Med Genet 2:142-155.[Free Full Text]
• Filipsson, R.; Lindsten, J.; and Almquist, S. (1965): Time of Eruption of the Permanent Teeth, Cephalometric and Tooth Measurements and Sulphation Factor Activity in 45 Patients with Turner's Syndrome with Different Types of X-chromosome Aberration, Acta Endocrinol (Kbh) 48:91-113.
• Garn, S.M. and Rohmann, C.G. (1962): X-linked Inheritance of Developmental Timing in Man, Nature 196:695-696.[CrossRef][Medline] [Order article via Infotrieve]
• Garn, S.M.; Lewis, A.B.; and Kerewsky, R.S. (1965): X-linked Inheritance of Tooth Size, J Dent Res 44:439-441.[Free Full Text]
• Kari, M.; Alvesalo, L.; and Manninen, K. (1980): Sizes of Deciduous Teeth in 45,X Females, J Dent Res 59:1382-1385.[Abstract/Free Full Text]
• Kraus, B.S. and Jordan, R.E. (1965): The Human Dentition before Birth, Philadelphia: Lea & Febiger, pp. 119-144.
• Lau, E.C.; Mohandas, T.K.; Shapiro, L.J.; Slavkin, H.C.; and Snead, M.L. (1989): Human and Mouse Amelogenin Gene Loci are on the Sex Chromosomes, Genomics 4:162-168.[CrossRef][Medline] [Order article via Infotrieve]
• Mayhall, J.T.; Alvesalo, L.; and Townsend, G. (1991): Tooth Crown Size in 46,Xi(Xq) Females, Arch Oral Biol (in press).
• Mittwoch, U. (1985): Males, Females and Hermaphrodites, Ann Hum Genet 50:103-121.[CrossRef]
• Osborne, R.H.; Horowitz, S.L.; and DeGeorge, F.V. (1958): Genetic Variation in Tooth Dimensions, A Twin Study of the Permanent Anterior Teeth, Am J Hum Genet 10:350-356.[Medline] [Order article via Infotrieve]
• Ounsted, C. and Taylor, D.C. (1972): The Y-chromosome Message: a Point of View. In: Gender Differences: Their Ontogency and Significance, C. Ounsted and D.C. Taylor, Eds., Edinburgh: Churchill Livingstone, pp. 241-262.
• Polani, P.B. and Polani, N. (1979): Dermatoglyphics in the Testicular Feminization Syndrome, Ann Hum Biol 6:417-430.[CrossRef][Medline] [Order article via Infotrieve]
• Simpson, J.L. (1976): Disorders of Sexual Differentiation, London: Academic Press, pp. 152-155, 292-293.
• Tanner, J.M.; Prader, A.; Habich, H.; and Ferguson-Smith, M.A. (1959): Genes on the Y-chromosome Influencing Rate of Maturation in Man, Lancet 2:141-144.[Medline] [Order article via Infotrieve]
• Townsend, G. and Alvesalo, L. (1985a): Tooth Size in 47,XYY Males-Evidence of a Direct Effect of the Y-chromosome on Growth, Aust Dent J 30:268-272.[Medline] [Order article via Infotrieve]
• Townsend, G. and Alvesalo, L. (1985b): The Size of Permanent Teeth in Klinefelter (47,XXY) Syndrome in Man, Arch Oral Biol 30:83-84.[CrossRef][Medline] [Order article via Infotrieve]
• Townsend, G.C.; Alvesalo, L.; Jensen, B.L.; and Kari, M. (1988): Patterns of Tooth Size in Chromosomal Aneuploidies. In: Teeth Revisited: Proceedings of VIIth International Symposium on Dental Morphology, D.E. Russell, J.P. Santoro, and D. Signogneau-Russell, Eds., Memoires Series, Paris: Museum National d'Histoire Naturelle, pp. 25-45.
• Townsend, G.; Jensen, B.L.; and Alvesalo, L. (1984): Reduced Tooth Size in 45,X (Turner Syndrome) Females, Am J Phys Anthropol 54:367-371.
• Varrela, J.; Townsend, G.; and Alvesalo, L. (1988): Tooth Crown Size in Human Females with 45, X/46,XX Chromosomes, Arch Oral Biol 33:291-294.[CrossRef][Medline] [Order article via Infotrieve]

Journal of Dental Research, Vol. 70, No. 7, 1057-1060 (1991)
DOI: 10.1177/00220345910700070801


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