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Hamster Cheek-pouch Testing of Dental Soft Polymers

Division of Oral Pathology, Faculty of Dentistry, Dalhousie University, Halifax, Nova Scotia, Canada B3H 3J5

W.C. Foong

Division of Dental Biomaterials Science, Faculty of Dentistry, Dalhousie University, Halifax, Nova Scotia, Canada B3H 3J5

R.E. Howell

Division of Oral Pathology, Faculty of Dentistry, Dalhousie University, Halifax, Nova Scotia, Canada B3H 3J5

P. Hidi

Division of Dental Biomaterials Science, Faculty of Dentistry, Dalhousie University, Halifax, Nova Scotia, Canada B3H 3J5

D.W. Jones

Division of Dental Biomaterials Science, Faculty of Dentistry, Dalhousie University, Halifax, Nova Scotia, Canada B3H 3J5

The hamster cheek pouch provides a suitable model system for the mucous-membrane irritation testing of dental materials. Poor retention of materials or difficulties in histopathological interpretation caused by surgical artifacts have been reported in published techniques. We describe a new "pouch-in-pouch" technique for mucous membrane irritation tests. The retention rate of polymer discs was 97% and 87% at 14 and 35 days, respectively. Clear differentiation was obtained between the tissue reaction to the test materials and the surgical procedure. Polymer discs containing dibutyltin diacetate (DBTD) or di-butyl phthalate (DBP) as plasticizer resulted in epithelial changes, including epithelial atypia, early papillomas, and areas resembling dysplasia. The potentially pre-malignant nature of these changes requires further investigation.

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Journal of Dental Research, Vol. 70, No. 6, 991-996 (1991)
DOI: 10.1177/00220345910700061701


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Harsanyi, B.B. Articles by Jones, D.W. Search for Related Content PubMed PubMed Citation Articles by Harsanyi, B.B. Articles by Jones, D.W. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Medline Plus Health Information Dentures Hazardous Substances DB DIBUTYL PHTHALATE DIBUTYLTIN DIACETATE TIN COMPOUNDS Social Bookmarking                         What's this?