This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Inoue, K. Articles by Creveling, C.R. Search for Related Content PubMed PubMed Citation Articles by Inoue, K. Articles by Creveling, C.R. Pubmed/NCBI databases Substance via MeSH Social Bookmarking                         What's this?

Immunocytochemical Evidence for the Site of O-methylation in Rat Dental Pulp

Department of Oral Anatomy, Okayama University, Dental School, Okayama 700, Japan

T. Nishino

Department of Oral Anatomy, Okayama University, Dental School, Okayama 700, Japan

C.R. Creveling

Laboratory of Bio-organic Chemistry, NIDDK, NIH, Bethesda, Maryland 20892

Immunocytochemical observations by light and electron microscopy of catechol-O-methyltransferase (COMT) were conducted in dental pulp by use of a specific antibody to soluble rat-liver COMT and the peroxidase-antiperoxidase technique. Immunoreactive deposits were found in macrophages. The pattern of localization suggests that COMT may function in extraneuronal inactivation of catecholamines in dental pulp.

REFERENCES

• Amin, A.M.; Creveling, C.R.; and Lowe, M.C. (1983): Immunohistochemical Localization of Catechol Methyltransferase in Normal and Cancerous Breast Tissues of Mice and Rats, J Natl Cancer Inst 70:337-342.[Medline] [Order article via Infotrieve]
• Bryan, L.I.; Fleig, H.; and Trendelenburg, H. (1983): A Comparative Study of the Properties of the Catechol-O-methyltransferase Inhibitors, U-0521 and Tropolone Acetamide, in Rat Perfused Heart, Naunyn-Schmiedeberg's Arch Pharmacol 322:6-19.[CrossRef][Medline] [Order article via Infotrieve]
• Creveling, C.R. (1984): The Functional Significance of the Cellular Localization of Catechol-O-methyltransferase. In: Stress: The Role of Catecholamine and Other Neurotransmitters, E. Usdin, R. Kvetnansky, and J. Axelrod, Eds., New York: Gordon and Breach, pp. 447-455.
• Creveling, C.R. and Hartman, B.K. (1982): Relationships between the Cellular Localization and the Physiological Function of Catechol-O-methyltransferase. In: Biochemistry of S-Adenosylmethionine and Related Compounds, E. Usdin, R.T. Borchardt, and C.R. Creveling, Eds., London: Macmillan, pp. 473-485.
• Fujita, H. (1989): Non-inflammatory and Non-immunological Defense Reaction by Fibroblasts, Biomed Res 10 (Suppl. 3):527-535.
• Fujita, H.; Nishii, Y.; Yamashita, K.; Kawamata, S.; and Yoshikawa, K. (1988): The Uptake and Long-term Storage of India Ink Particles and Latex Beads by Fibroblasts in the Dermis and Subcutis of Mice, with Special Regard to the Non-inflammatory Defense Reaction by Fibroblasts, Arch Histol Cytol 51:285-294.[Medline] [Order article via Infotrieve]
• Fujita, H.; Ueda, A.; Nishida, T.; and Otori, T. (1987): Uptake of India Ink Particles and Latex Beads by Comeal Fibroblasts, Cell Tissue Res 250:251-255.[Medline] [Order article via Infotrieve]
• Groshong, R.; Baldessarini, R.J.; and Gibson, D.A. (1978): Activities of Type A and B MAO and Catechol-O-methyltransferase in Blood Cells and Skin Fibroblasts of Normal and Chronic Schizophrenic Subjects, Arch Gen Psychiatry 35:1198-1205.[Abstract/Free Full Text]
• Grossman, M.H.; Creveling, C.R.; Rybcynski, R.; Braverman, M.; Isersky, C.; and Breakfield, X.O. (1985): Soluble and Particulate Forms of Rat Catechol-O-methyltransferase Distinguished by Gel Electrophoresis and Immune Fixation, J Neurochem 44:421-432.[CrossRef][Medline] [Order article via Infotrieve]
• Inoue, K. and Creveling, C.R. (1980): Immunocytochemical Localization of Catechol-0-methyltransferase in Lymphoid Tissue and Bone Marrow of Rat, Acta Histochem Cytochem 13:368-376.
• Inoue, K. and Creveling, C.R. (1986): Immunocytochemical Localization of Catechol-O-methyltransferase in the Oviduct and in Macrophages in Corpora Lutea of Rat, Cell Tissue Res 245:623-628.[Medline] [Order article via Infotrieve]
• Inoue, K.; Tice, L.W.; and Creveling, C.R. (1977): Immunocytochemical Localization of Catechol-O-methyltransferase. In: Biochemistry and Function of Monoamine Enzymes, E. Usdin, N. Weiner, and M.B.H. Youdim, Eds., New York: Marcel Dekker, Inc., pp. 835-859.
• Jacobowitz, D.M. (1972): Localization of Catechol-O-methyltransferase and Monoamine Oxidase in Fibroblasts in Tissue Culture, Life Sci 11:965-974.[CrossRef]
• Parker, D.A.S.; De LA Landa, I.S.; Proctor, C.; Mario, V.; Lam, N.X.; and Parker, I. (1987): Cocaine-sensitive 0-methylation of Noradrenaline in Dental Pulp of the Rabbit: Comparison with the Rabbit Ear Artery, Naunyn-Schmiedeberg's Arch Pharmacol 335:32-39.[CrossRef][Medline] [Order article via Infotrieve]
• Sontheimer, R.D. (1989): Perivascular Dendritic Macrophages and Immunobiological Constituents of the Human Dermal Microvascular Unit, J Invest Dermatol 93 (Suppl 2):96-101.[CrossRef][Medline] [Order article via Infotrieve]
• Speer, C.P. and Gahr, M. (1989): The Monocyte-Macrophage System in the Human, Monatsschr Kinderheilkd 137:390-395.[Medline] [Order article via Infotrieve]
• Stefanni, M.; DE Martino, C.; and Zamboni, L. (1967): Fixation of Ejaculated Spermatozoa for Electron Microscopy, Nature 216:173-174.[CrossRef][Medline] [Order article via Infotrieve]
• Ten Cate, A.R. (1989): Oral Histology, 3rd ed., St. Louis: The C.V. Mosby Company, p. 180.
• Thakker, D.R. and Creveling, C.R. (1989): O-methylation. In: Conjugation Reactions in Drug Metabolism, G.J. Mulder, Ed., London: Taylor and Francis, pp. 193-232.
• Trendelenburg, U. (1980): A Kinetic Analysis of the Extra-neuronal Uptake and Metabolism of Catecholamines, Rev Physiol Biochem Phannacol 87:33-115.[CrossRef]

Journal of Dental Research, Vol. 70, No. 6, 966-969 (1991)
DOI: 10.1177/00220345910700061101


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Inoue, K. Articles by Creveling, C.R. Search for Related Content PubMed PubMed Citation Articles by Inoue, K. Articles by Creveling, C.R. Pubmed/NCBI databases Substance via MeSH Social Bookmarking                         What's this?