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Effects of Topical and Systemic Nicotine on Gingival Blood Flow in Dogs

University of Nebraska Medical Center, College of Dentistry, 40th and Holdrege Streets, Lincoln, Nebraska 68583-0740

G.L. Todd

University of Nebraska Medical Center, 600 South 42nd Street, Omaha, Nebraska 68198

W.T. Johnson

University of Nebraska Medical Center, College of Dentistry, 40th and Holdrege Streets, Lincoln, Nebraska 68583-0740

Y.K. Fung

University of Nebraska Medical Center, College of Dentistry, 40th and Holdrege Streets, Lincoln, Nebraska 68583-0740

L.M. Dubois

University of Nebraska Medical Center, College of Dentistry, 40th and Holdrege Streets, Lincoln, Nebraska 68583-0740

It has been suggested that due to its vasoconstrictive action, nicotine may have a deleterious effect on the periodontium. This study examined the effects of topical and systemic nicotine administration on gingival blood flow. Eighteen young adult dogs were divided into three groups receiving the following treatments for 28 days: topical nicotine in orabase, systemic nicotine via osmotic mini-pumps, and topical orabase or systemic saline via osmotic mini-pumps. Blood flow to the gingiva was measured (at days 0 and 28) by the radiolabeled microsphere method. Blood flow was consistently increased from day 0 to day 28 in the nicotine-treated animals. Comparison of days 0 and 28 blood-flow values demonstrated a statistically significant change (p<0.05) in the anterior regions of the topical-nicotine group as compared with the control group. The increased flow may be a reflection of the mode of nicotine delivery and timing of the blood-flow determination procedures.

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Journal of Dental Research, Vol. 70, No. 5, 906-909 (1991)
DOI: 10.1177/00220345910700050801


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Johnson, G.K. Articles by Dubois, L.M. Search for Related Content PubMed PubMed Citation Articles by Johnson, G.K. Articles by Dubois, L.M. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB NICOTINE NICOTINE TARTRATE Social Bookmarking                         What's this?