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Immunocytochemical Evidence for the Presence of Somatostatin-like Immunoreactive Nerves in Human Dental Pulp

Institute of Histology and Embryology, University of Pavia, Via Forlanini 10, 27100 Pavia, Italy

A. Calligaro

Institute of Histology and Embryology, University of Pavia, Via Forlanini 10, 27100 Pavia, Italy

M. Casasco

Institute of Histology and Embryology, University of Pavia, Via Forlanini 10, 27100 Pavia, Italy

D.R. Springall

Department of Histochemistry, Royal Postgraduate Medical School, Du Cane Road, London W12 ONN, England

J.M. Polak

Department of Histochemistry, Royal Postgraduate Medical School, Du Cane Road, London W12 ONN, England

C. Marchetti

Institute of Histology and Embryology, University of Pavia, Via Forlanini 10, 27100 Pavia, Italy

Specific antiserum to somatostatin was used for the immunocytochemical detection of this neuropeptide in human dental pulp. Immunoreactive axon varicosities were observed in the radicular as well as coronal pulp. Fibers displaying somatostatin-like immunoreactivity were detectable within radicular nerve trunks and were found to be associated mainly with blood vessels. Nevertheless, positive fibers with no apparent relation to blood vessels were also observed. No pulp cell was found to be immunoreactive. Previous physiological studies demonstrated that somatostatin may function as a regulatory peptide in feline dental pulp via a pre-synaptic inhibition of substance P release from sensory nerve terminals. It is tempting to speculate that such a mechanism may also be effective in human teeth and may be of value in the regulation of pulpal blood flow and in situations when sensory nerve fibers are activated, e.g., during pulpal inflammation.

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Journal of Dental Research, Vol. 70, No. 2, 87-89 (1991)
DOI: 10.1177/00220345910700021601


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Casasco, A. Articles by Marchetti, C. Search for Related Content PubMed PubMed Citation Articles by Casasco, A. Articles by Marchetti, C. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Social Bookmarking                         What's this?