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Twin Half-sibs: A Research Design for Genetic Epidemiology of Common Dental Disorders
R.H. Potter
Indiana University Oral Health Research Institute, 415 Lansing Street, Indianapolis, Indiana 46202
Dental caries and the chronic type of periodontal disease are classic examples of common familial diseases that are complex and multifactorial in etiology. Due to previous methodological limitations, there is no information at present on the genetic and shared environmental risks within families that account for familial aggregation of these diseases. Such information, however, is needed in the long run to help specify modifiable family environments that affect the frequency and/or severity of the disease, and thereby to aid in the planning of prevention strategies to be targeted at the family level. Recently, an innovative genetic model has been described to test the genetic and environmental basis of chronic familial diseases in identical (monozygotic) twins, their spouses, and their offspring, who are genetically half-sibs. In this paper, the method is detailed and shown to be appropriate not only for partitioning shared genetic and environmental risks within families, but also for delineating maternal effects and assortative mating as two non-genetic mechanisms that may ultimately be found to affect the incidence of disease.
REFERENCES
- Christian, J.C. (1978): The Use of Twin Registers in the Study of Birth Defects, Birth Defects: Orig Art Ser 14(6A):167-178.[Medline]
[Order article via Infotrieve]
- Christian, J.C. and Kang, K.W. (1977): Maternal Influence on Plasma Cholesterol Variation, Am J Hum Genet 29:462-467.[Medline]
[Order article via Infotrieve]
- Falconer, D.S. (1981): Introduction to Quantitative Genetics, New York: Longman, pp. 134-169.
- Fisher, R.A. (1918): The Correlation Between Relatives on the Supposition of Mendelian Inheritance, Trans R Soc Edinb 52:399-433.
- Kang, K.W.; Lindemann, J.P.; Christian, J.C.; Nance, W.E.; and Norton, J.A., Jr. (1974): Sampling Variances in Twin and Sibling Studies of Man, Human Heredity 24:363-372.[Medline]
[Order article via Infotrieve]
- Morton, N.E. and Rao, D.C. (1978): Quantitative Inheritance in Man, Yearbook Phys Anthropol 21:12-41.
- Myrianthopoulos, N.C. (1978): An Approach to the Investigation of Maternal Factors in Congenital Malformations. In: Genetic Epidemiology, N.E. Morton and C.S. Chung, Eds., New York: Academic Press, pp. 363-374.
- Nance, W.E. (1976): Genetic Studies of the Offspring of Identica Twins, Acta Genet Med Gemellol 25:96-104.
- Nance, W.E.; Corey, L.A.; and Boughman, J.A. (1978): Monozygotic Twin Kinships: A New Design for Genetic and Epidemiologic Research. In: Genetic Epidemiology, N.E. Morton and C.S. Chung, Eds., New York: Academic Press, pp. 87-132.
- Potter, R.H. (1989): Etiology of Periodontitis: The Heterogeneity Paradigm (Guest Editorial), J Periodontol 60:593-597.[Medline]
[Order article via Infotrieve]
- Reed, T.; Evans, M.M.; Norton, J.A., Jr.; and Christian, J.C. (1979): Maternal Effects on Fingertip Dermatoglyphics, Am J Hum Genet 31:315-323.[Medline]
[Order article via Infotrieve]
- Rose, R.J.; Boughman, J.A.; Corey, L.A.; Nance, W.E.; Christian, J.C.; and Kang, K.W. (1980): Data from Kinships of Monozygotic Twins Indicate Maternal Effects on Verbal Intelligence, Nature 283:375-377.[Medline]
[Order article via Infotrieve]
- Sperber, G.H. (1989): Craniofacial Embryology, Boston: John Wright and Sons, pp. 215-228.
Journal of Dental Research, Vol. 69, No. 8,
1527-1530 (1990)
DOI: 10.1177/00220345900690081601
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