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Caries Incidence in Intact Rats Infected with Streptococcus sobrinus via Transmission from Desalivated Cagemates

University of Rochester, Rochester Cariology Center, Department of Dental Research, 601 Elmwood Avenue, Rochester, New York 14642

W.H. Bowen

University of Rochester, Rochester Cariology Center, Department of Dental Research, 601 Elmwood Avenue, Rochester, New York 14642

S.K. Pearson

University of Rochester, Rochester Cariology Center, Department of Dental Research, 601 Elmwood Avenue, Rochester, New York 14642

J.L. Falany

University of Rochester, Rochester Cariology Center, Department of Dental Research, 601 Elmwood Avenue, Rochester, New York 14642

The purpose of this study was to determine the influence of caging desalivated S. sobrinus-infected rats on the caries incidence in intact, previously uninfected cagemates. Weanlings were divided as follows: Stage I: Twenty desalivated animals paired with 20 intact animals (Group I); 20 intact animals paired with 20 intact animals (Group II). Animals were infected with S. sobrinus and fed diet 2000 and 10% sucrose water. After five weeks, ten paired animals from each group were killed. Desalivated animals had statistically higher (p<0.05) caries scores than did other animals. Stage II: The remaining Stage I infected animals from Groups I and II were paired with 40 new uninfected animals 15 days of age and fed cariogenic diets. After five weeks, new intact animals paired with Stage I desalivated animals had significantly higher smooth-surface enamel caries scores (38.0; SE 7.84) than new intact animals paired with Stage I intact animals (11.15 ; SE 3.69). Moreover, new intact animals caged for only five weeks with Stage I desalivated animals developed smooth-surface caries (38.0; SE 7.84) to a degree comparable with that in all Stage I intact animals in the experiment for ten weeks (36.6, SE 9.5 ; and 30.05, SE 4.1). The data suggest that desalivation may select a readily transmissible strain of S. sobrinus, which demonstrates enhanced virulence.

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Journal of Dental Research, Vol. 69, No. 5, 1154-1159 (1990)
DOI: 10.1177/00220345900690050701


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Madison, K.M. Articles by Falany, J.L. Search for Related Content PubMed PubMed Citation Articles by Madison, K.M. Articles by Falany, J.L. Pubmed/NCBI databases Medline Plus Health Information Streptococcal Infections Social Bookmarking                         What's this?