This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Henry, R.J. Articles by Quock, R.M. Search for Related Content PubMed PubMed Citation Articles by Henry, R.J. Articles by Quock, R.M. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Medline Plus Health Information Alcoholism Hazardous Substances DB ETHANOL NITROUS OXIDE Social Bookmarking                         What's this?

Influence of Chronic Ethanol Exposure on Nitrous Oxide Analgesia in Mice

Department of Pediatric Dentistry, University of Florida College of Dentistry, Box J-426, J. Hillis Miller Health Center, Gainesville, Florida 32610

M.M. Ishii

Department of Psychology, Marquette University

R.M. Quock

Department of Basic Sciences, Marquette University School of Dentistry, Milwaukee, Wisconsin 53233

The purpose of this study was to determine whether sensitivity to nitrous oxide analgesia was altered by chronic ethanol exposure. Control mice exposed to 25%, 50%, and 75% nitrous oxide in oxygen demonstrated a concentration-related analgesic effect, as measured by the acetic acid abdominal constriction test. Other mice previously exposed to ethanol vapors for 72 h exhibited a significantly reduced sensitivity to nitrous oxide analgesia. The dose-response curve of the chronic ethanol-exposed group was shifted to the right of that of the control mice. These findings suggest the possibility that subjects with a history of alcohol abuse might have reduced responsiveness to nitrous oxide in a clinical setting.

REFERENCES

• Allen, G.D. (1984): Dental Anesthesia and Analgesia (Local and General), 3rd ed., Baltimore: Williams and Wilkins, pp. 254-266.
• Belknap, J.K.; Laursen, S.E.; and Crabbe, J.C. (1987): Ethanol and Nitrous Oxide Produce Withdrawal-induced Convulsions by Similar Mechanisms in Mice, Life Sci 41:2033-2040.[CrossRef][Medline] [Order article via Infotrieve]
• Berkowitz, B.A.; Finck, A.D.; Hynes, M.D.; and Ngai, S.H. (1979): Tolerance to Nitrous Oxide Analgesia in Rats and Mice, Anesthesiol 51:309-312.[CrossRef][Medline] [Order article via Infotrieve]
• Blum, K. (1977): Alcohol and Opiates. Neurochemical and Behavioral Mechanisms, New York: Academic Press, pp. 203-236.
• Boada, J.; Feria, M.; and Sanz, E. (1981): Inhibitory Effect of Naloxone on the Ethanol-induced Antinociception in Mice, Pharmacol Res Comm 13:673-678.[Medline] [Order article via Infotrieve]
• Bourne, J.G. (1967): Studies in Anaesthetics, Including Intravenous Dental Anaesthesia, London: Lloyd-Luke, pp. 131-137.
• Christen, A.G. (1983): Dentistry and the Alcoholic Patient, Dent Clin North Am 27:341-361.[Medline] [Order article via Infotrieve]
• Fidecka, A.; Tamborska, E.; and Langwinski, R. (1986): The Development of Cross Tolerance Between Ethanol and Morphine, Pol J Pharmacol Pharm 38:277-284.[Medline] [Order article via Infotrieve]
• Gillman, M.A. (1984): Possible Mechanisms of Action of Nitrous Oxide at the Opioid Receptor, Med Hypoth 15:109-114.[Medline] [Order article via Infotrieve]
• Goldstein, D.B. (1972): An Animal Model for Testing Effects of Drugs on Alcohol Withdrawal Reactions, J Pharmacol Exp Ther 183:14-22.[Abstract/Free Full Text]
• Goldstein, D.B. and Pal, N. (1971): Alcohol Dependence Produced in Mice by Inhalation of Ethanol: Grading Withdrawal Reaction, Science 172:288-290.[Abstract/Free Full Text]
• Han, Y.H. (1969): Why Do Chronic Alcoholics Require More Anesthesia?, Anesthesiol 30:341-342.
• James, M.F.M.; Duthie, A.M.; Duffy, B.K.; McKeag, A.M.; and Rice, C.P. (1978): Analgesic Effect of Ethyl Alcohol, Br J Anaesth 50:139-141.[Abstract/Free Full Text]
• Keilty, S.R. (1969): Anesthesia for the Alcoholic Patient, Anesth Analg 48:659-664.[Free Full Text]
• Koblin, D.D. and Deady, J.E. (1981): Anaesthetic Requirement in Mice Selectively Bred for Differences in Ethanol Sensitivity, Br J Anaesth 53:5-10.[Abstract/Free Full Text]
• Koblin, D.D.; Deady, J.E.; Dong, D.E.; and Eger, E.I. (1980): Mice Tolerant to Nitrous Oxide are Also Tolerant to Alcohol, J Pharmacol Exp Ther 213:309-312.[Abstract/Free Full Text]
• Koblin, D.D.; Deady, J.E.; and Eger, E.I. (1982): Potencies of Inhaled Anesthetics and Alcohol in Mice Selectively Bred for Resistance and Susceptibility to Nitrous Oxide Anesthesia, Anesthesiol 56:18-24.[CrossRef][Medline] [Order article via Infotrieve]
• Langa, H. (1976): Relative Analgesia in Dental Practice - Inhalation Analgesia with Nitrous Oxide, Philadelphia: Saunders, pp. 79-102.
• Malec, D.; Kotlinska, J.; and Langwinski, R. (1987): Cross-Tolerance between Morphine and Ethanol and Their Antinociceptive Effects, J Stud Alcohol 48:507-510.[Medline] [Order article via Infotrieve]
• Mello, N.K. (1976): Animal Models for the Study of Alcohol Addiction, Psychoneuroendocrinol 1:347-357.[CrossRef]
• Pohorecky, L.A. and Shah, P. (1987): Ethanol-induced Analgesia, Life Sci 41:1285-1289.
• Quock, R.M. and Graczak, L.M. (1988): Influence of Narcotic Antagonist Drugs Upon Nitrous Oxide Analgesia in Mice, Brain Res 440:35-41.[Medline] [Order article via Infotrieve]
• Quock, R.M.; Kouchich, F.J.; and Tseng, L.F. (1986): Does Nitrous Oxide Induce Release of Brain Opioid Peptides?, Pharmacology 30:95-99.
• Tammisto, T. and Takki, S. (1973): Nitrous Oxide-Oxygen-Relaxant Anaesthesia in Alcoholics: A Retrospective Study, Acta Anaesth Scand 53 (Suppl):68-75.
• Tammisto, T. and Tigerstedt, 1. ( 1977): The Need for Halothane Supplementation of N2O-O2 Relaxant Anesthesia in Chronic Alcoholics, Acta Anaesthesiol Scand 21:17-23.[Medline] [Order article via Infotrieve]
• Williamson, R. and Davis, C.L. (1973): Drug-dependent, Alcohol-dependent, and Mental Patients: Clinical Study of Oral Surgery Procedures, J Am Dent Assoc 86:416-419.[Medline] [Order article via Infotrieve]
• Woodrow, K.M. and Eltherington, L.G. (1988): Feeling No Pain: Alcohol as an Analgesic, Pain 32:159-163.[CrossRef][Medline] [Order article via Infotrieve]
• Zuniga, J.R.; Joseph, S.A.; and Knigge, K.M. (1987a): The Effects of Nitrous Oxide on the Central Endogenous Pro-opiomelanocortin System in the Rat, Brain Res 420:57-65.[Medline] [Order article via Infotrieve]
• Zuniga, J.R.; Joseph, S.A.; and Knigge, K.M. (1987b): The Effects of Nitrous Oxide on the Secretory Activity of Pro-opiomelanocortin Peptides from Basal Hypothalamic Cells Attached to Cytodex Beads in a Superfusion in vitro System, Brain Res 420:66-72.[CrossRef][Medline] [Order article via Infotrieve]

Journal of Dental Research, Vol. 69, No. 10, 1674-1677 (1990)
DOI: 10.1177/00220345900690100901


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				T. D. Rees Oral Effects of Drug Abuse Critical Reviews in Oral Biology & Medicine, January 1, 1992; 3(3): 163 - 184. [Abstract] [Full Text] [PDF]

This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Henry, R.J. Articles by Quock, R.M. Search for Related Content PubMed PubMed Citation Articles by Henry, R.J. Articles by Quock, R.M. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Medline Plus Health Information Alcoholism Hazardous Substances DB ETHANOL NITROUS OXIDE Social Bookmarking                         What's this?