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The Growth-inhibitory Effect of the Enterococcus faecalis Bacteriocin Encoded by pADl Extends to the Oral Streptococci

University of Oklahoma Health Sciences Center, Department of Microbiology and Immunology, Biomedical Science Building, Room 1035, P.O. Box 26901, Oklahoma City, Oklahoma 73190

M.S. Gilmore

University of Oklahoma Health Sciences Center, Department of Microbiology and Immunology, Biomedical Science Building, Room 1035, P.O. Box 26901, Oklahoma City, Oklahoma 73190

Many strains of Enterococcus faecalis, a normal inhabitant of the oral cavity, elaborate a plasmid-encoded bacteriocin. The growth-inhibitory effect of this bacteriocin was observed to extend to a variety of pathogenic oral streptococci, including those that play a major role in tooth surface colonization and caries formation. These results suggest that transient colonization by bacteriocin-producing E. faecalis may effect shifts in oral colonization by susceptible organisms and that bacteriocin-producing E. faecalis may be a candidate for application in strain replacement therapy.

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Journal of Dental Research, Vol. 69, No. 10, 1640-1645 (1990)
DOI: 10.1177/00220345900690100301


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