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Effects of Thyroxine and Dexamethasone on Rat Submandibular Glands

Departments of Prosthodontics and Physiology, Karolinska Institutet, Box 4064, S141-04 Huddinge, Sweden

G.M. Roomans

Department of Ultrastructure Research, University of Stockholm, Department of Human Anatomy, University of Uppsala, Uppsala, Sweden

Glucocorticoids and thyroxine are known to have a marked effect on the flow rate and protein composition of rat parotid saliva in hormonally intact animals. In the present study, the effects of a one-week treatment of male rats with dexamethasone and thyroxine were studied by electron microscopy and x-ray micro-analysis, and by measurement of the flow rate and determination of the chemical composition of pilocarpine-induced submandibular saliva. Thyroxine had the most extensive effects on the submandibular gland. The acinar cells were enlarged and filled with mucus; the cellular calcium concentration was significantly increased. The flow rate of the submandibular saliva was significantly reduced compared with that in saline-injected control animals. Thyroxine caused an increase in the concentrations of protein, total calcium, and potassium in the saliva. Dexamethasone had no significant effects on gland ultrastructure or on the elemental composition of the acinar cells; flow rate was not affected, but the concentrations of protein, calcium, and potassium were significantly increased. The effects of dexamethasone and thyroxine on the flow rate and protein composition of pilocarpine-induced rat submandibular saliva differ from those reported earlier for rat parotid saliva after simultaneous stimulation with pilocarpine and isoproterenol.

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Journal of Dental Research, Vol. 68, No. 8, 1247-1251 (1989)
DOI: 10.1177/00220345890680080701


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Sagulin, G.-B. Articles by Roomans, G.M. Search for Related Content PubMed PubMed Citation Articles by Sagulin, G.-B. Articles by Roomans, G.M. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB CALCIUM COMPOUNDS CALCIUM, ELEMENTAL DEXAMETHASONE LEVOTHYROXINE POTASSIUM Social Bookmarking                         What's this?