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Effect of an Acute Maternal Fluoride Dose on Fetal Plasma Fluoride Levels and Enamel Fluoride Uptake in Guinea Pigs

Department of Pediatric Dentistry, the Dental Research Center, University of North Carolina at Chapel Hill, Department of Biostatistics, University of North Carolina at Chapel Hill

T.G. Deaton

Department of Pediatric Dentistry, the Dental Research Center, University of North Carolina at Chapel Hill, Department of Biostatistics, University of North Carolina at Chapel Hill

G.G. Koch

Department of Pediatric Dentistry, the Dental Research Center, University of North Carolina at Chapel Hill, Department of Biostatistics, University of North Carolina at Chapel Hill

B.P. Crawford

Department of Pediatric Dentistry, the Dental Research Center, University of North Carolina at Chapel Hill, Department of Biostatistics, University of North Carolina at Chapel Hill

We conducted this study to measure maternal plasma, fetal plasma, and fetal enamel fluoride concentrations for four hours following an oral F dose to near-term pregnant guinea pigs.

We placed female guinea pigs on de-ionized (Group I) or 3-ppm-F (Group II) drinking water prior to breeding and during gestation. On the 57th day of gestation, we administered a maternal dose of NaF solution (0.6 mg Flkg) by stomach tube. We collected samples of maternal plasma, fetal plasma, and fetal enamel at baseline, at 15 and 30 min, and at one, two, and four h after administration of the dose. We assayed samples for F using a modification of the micro-diffusion and ion-specific electrode method.

Group I mean baseline F values were: maternal plasma, 0.016; fetal plasma, 0.002 ; and fetal enamel, 7. 0 ppm. Group II mean values were: 0.055, 0.004, and 19.0 ppm. After the maternal fluoride dose, the mean maternal plasma [F] rose sharply for 30 to 60 min and declined to about 50% of peak values by four h. Fetal plasma [F] changed less in absolute values, but similarly to maternal changes relative to baseline. Fetal enamel mean [F] rose more in Group II than in Group I.

Baseline F status had an important effect on F uptake in fetal enamel following an actue maternal fluoride dose.

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Journal of Dental Research, Vol. 68, No. 7, 1169-1172 (1989)
DOI: 10.1177/00220345890680070601


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Bawden, J.W. Articles by Crawford, B.P. Search for Related Content PubMed PubMed Citation Articles by Bawden, J.W. Articles by Crawford, B.P. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Social Bookmarking                         What's this?