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The Concentration of Dietary Casein Required for Normal Mandibular Growth in the Rat

Department of Physiology, Faculty of Dentistry, University of Buenos Aires, M. T. de Alvear 2142, Buenos Aires (1122), República Argentina

A.C. Barcelo

Department of Physiology, Faculty of Dentistry, University of Buenos Aires, M. T. de Alvear 2142, Buenos Aires (1122), República Argentina

R.M. Alippi

Department of Physiology, Faculty of Dentistry, University of Buenos Aires, M. T. de Alvear 2142, Buenos Aires (1122), República Argentina

T.L. Leal

Department of Physiology, Faculty of Dentistry, University of Buenos Aires, M. T. de Alvear 2142, Buenos Aires (1122), República Argentina

C.E. Bozzini

Department of Physiology, Faculty of Dentistry, University of Buenos Aires, M. T. de Alvear 2142, Buenos Aires (1122), República Argentina

To determine a suitable casein concentration for normal, undeformed mandibular growth, we placed weanling male rats on diets containing graded levels of casein between 0% and 30% for 19 days. Some weanlings were killed so that initial values could be established. Ten linear dimensions corresponding to the six skeletal units of the mandible were evaluated so that their growth rates at the end of the experimental period could be established. Other dimensions were also evaluated for study of the growth rate of the bone as a whole. The macroscopic growth of the mandible showed a sigmoidal relationship with dietary casein concentration, most of the measurements reaching a plateau at 20% casein. Within the skeletal units, four dimensions corresponding to the alveolar and symphyseal regions did not change with age and were not affected by the casein content of the diet. The remaining six dimensions-corresponding to condylar, coronoid, angular, and basal regions of the mandible-increased with age and were related positively to dietary casein concentration. Their growth patterns were not uniform, although all of them reached maximal values when the diet contained 20% casein. Therefore, deformation of the mandible appears to occur in rats fed diets with a casein concentration lower than 20%. It appears that a dietary casein concentration of 20% is required for normal, undeformed mandibular growth.

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Journal of Dental Research, Vol. 68, No. 5, 840-842 (1989)
DOI: 10.1177/00220345890680051801


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Bozzini, C. Articles by Bozzini, C.E. Search for Related Content PubMed PubMed Citation Articles by Bozzini, C. Articles by Bozzini, C.E. Social Bookmarking                         What's this?