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Studies on Fluoride Concentrations in Human Submandibular/Sublingual Saliva and their Relation to Flow Rate and Plasma Fluoride Levels

Department of Cariology, School of Dentistry, Karolinska Institutet, Box 4064, S-141 04 Huddinge, Sweden

F. Lagerlof

Department of Cariology, School of Dentistry, Karolinska Institutet, Box 4064, S-141 04 Huddinge, Sweden

J. Ekstrand

College of Dentistry, Specialized Caries Research Center, University of Iowa, Iowa City, Iowa 52242, USA

C. Dawes

Department of Oral Biology, Faculty of Dentistry, University of Manitoba, Winnipeg, Canada R3E OW2

Submandibular/sublingual saliva and blood were collected from five subjects after ingestion of 1 mg fluoride as NaF. An individual collection device, made from a silicone impression material, was used to collect the saliva in 10-minute samples, before and during 2 hr after the fluoride intake. In two separate experiments on each individual, submandibular/sublingual saliva was collected continuously at different flow rates: without stimulation and with gustatory stimulation. Blood was also collected at intervals throughout the experiments. The concentration of fluoride in the submandibularlsublingual saliva was less than that in the plasma but independent of salivary flow rate. The ratio between the saliva and plasma fluoride concentrations at the peak of the mean plasma fluoride concentrations was 0.55 ± 0.13 and 0.69 ± 0.11 in the experiments on unstimulated and stimulated salivary flow rate, respectively. The total amount of the ingested fluoride dose that was excreted through the submandibular/sublingual glands during 130 min was highly correlated with the salivary flow rate. The fraction of the ingested fluoride dose excreted in 2 hr was 0.04 ± 0.02% in the unstimulated saliva and 0.15 ± 0.09% in the stimulated saliva.

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Journal of Dental Research, Vol. 68, No. 2, 146-149 (1989)
DOI: 10.1177/00220345890680020901


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Oliveby, A. Articles by Dawes, C. Search for Related Content PubMed PubMed Citation Articles by Oliveby, A. Articles by Dawes, C. Social Bookmarking                         What's this?