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Fluoride Redeposition and Retention during Bone Turnover in Lactating Rats

Department of Oral Biology and Program in Biochemistry, School of Dentistry, University of Minnesota, Minneapolis, Minnesota 55455

M.K. Guo

Department of Oral Biology and Program in Biochemistry, School of Dentistry, University of Minnesota, Minneapolis, Minnesota 55455

H.H. Messer

Department of Oral Biology and Program in Biochemistry, School of Dentistry, University of Minnesota, Minneapolis, Minnesota 55455

R.H. Ophaug

Department of Oral Biology and Program in Biochemistry, School of Dentistry, University of Minnesota, Minneapolis, Minnesota 55455

The ability of the adult skeleton to retain fluoride (F) during times of Ca stress was assessed in lactating rats. Rats incorporated F into their skeletons throughout growth by consumption of water containing 50 ppm F from weaning to 11 weeks of age. The rats were then changed to a low-F intake and mated. At delivery, nine dams were killed as a baseline group, and 20 dams were fed a low-F diet plus distilled water during lactation. Half of the rats were subjected to the additional stress of a low-Ca intake to stimulate bone resorption. F loss was determined during lactation. Bone turnover was measured by the loss of previously incorporated tritiated tetracycline (³H-TC), and changes in bone Ca and F contents were compared with changes in ³H-TC content. The extent of bone resorption ranged from 16.5% in the humerus of the adequate-Ca group to 77.1% in the vertebrae of Ca-deficient dams. Loss of bone F was greatest in animals with greatest loss of 3H-TC. Once F was resorbed from bone, only a relatively small portion was redeposited (0-31.4%). The low extent of F redeposition appears to be related to a low Ca deposition in lactating rats.

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Journal of Dental Research, Vol. 67, No. 9, 1213-1216 (1988)
DOI: 10.1177/00220345880670091201


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Nopakun, J. Articles by Ophaug, R.H. Search for Related Content PubMed PubMed Citation Articles by Nopakun, J. Articles by Ophaug, R.H. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB CALCIUM COMPOUNDS CALCIUM, ELEMENTAL Social Bookmarking                         What's this?