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Abnormal Amino Acid Analyses Obtained from Osteogenesis Imperfecta Dentin

Department of Restorative Dentistry, University of Queensland Dental School, Turbot Street, Brisbane, Queensland 4000, Australia

M.J.O. Francis

Nuffield Orthopœdic Centre, Oxford, United Kingdom

R. Smith

Nuffield Orthopœdic Centre, Oxford, United Kingdom

Amino acid analyses were carried out on dentin proteins obtained from 33 normal teeth and 59 teeth from osteogenesis imperfecta patients. The analyses revealed that in the control teeth approximately 95% of the insoluble dentin fraction was collagen. The majority of the analyses for teeth obtained from the O.I. patients were biochemically abnormal (55 out of 59). Specifically, there was a significant increase in the acidic amino acids, with a corresponding decrease in the basic amino acids. A small group of patients showed double peaks in the histidine, hydroxylysine, and lysine areas of the chromatograms. These results emphasize that despite the fact that the teeth of O.I. patients may appear to be clinically normal, all but four of the teeth examined had abnormal dentin collagen.

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Journal of Dental Research, Vol. 67, No. 8, 1097-1102 (1988)
DOI: 10.1177/00220345880670080701


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Gage, J.P. Articles by Smith, R. Search for Related Content PubMed PubMed Citation Articles by Gage, J.P. Articles by Smith, R. Pubmed/NCBI databases Substance via MeSH Genetics Home Reference Medline Plus Health Information Osteogenesis Imperfecta Social Bookmarking                         What's this?