|
Sign In to gain access to subscriptions and/or personal tools.
|
In vitro Studies on the Potential for Pulpal Cytotoxicity of Glass-Ionomer Cements
W.R. Hume
Department of Dentistry, The University of Adelaide, Adelaide 5000, Australia
G.J. Mount
Department of Dentistry, The University of Adelaide, Adelaide 5000, Australia
Elution samples of glass-ionomer cement were prepared in sterile tissue culture medium either by direct contact between the fluid and standard cement samples or through a layer of human dentin, and then tested for toxicity to cultured mouse fibroblasts (L929). The directly-prepared eluates of the cements were highly cytotoxic, but those prepared through dentin were of either limited or no cytotaxicity. The degree of toxicity of some directly-prepared eluates was reduced by adjustment of the pH to neutrality. It was apparent that dentin reduced the potential for cytotoxicity of glass-ionomer cements to a large degree. Proposed mechanisms for the reduction were limited availability of water at the dentin-cement interface and thus limited dissolution of components, buffering of acid components of the cements by dentin, or other chemical interactions with dentin.
REFERENCES
- Cooper, I.R. (1980): The Response of the Human Dental Pulp to Glass Ionomer Cements, Int Endodont J 13:76-88.
- Council On Dental Materials, Instruments And Equipment (1984): Reported Sensitivity to Glass Ionomer Luting Cements, J Am Dent Assoc 109:476.[Medline]
[Order article via Infotrieve]
- Dahl, B.L. and Tronstad, L. (1976): Biological Tests of an Experimental Glass Ionomer (Silicopolyacrylate) Cement, J Oral Rehabil 3:19-24.[CrossRef][Medline]
[Order article via Infotrieve]
- Hanks, C.T.; Anderson, M.; and Craig, R.G. (1981): Cytotoxic Effects of Dental Cements in Two Cell Culture Systems, J Oral Pathol 10:101-112.[CrossRef][Medline]
[Order article via Infotrieve]
- Hume, W.R. (1984a): An Analysis of the Release and the Diffusion Through Dentin of Eugenol from Zinc Oxide-Eugenol Mixtures, J Dent Res 63:881-884.[Abstract/Free Full Text]
- Hume, W.R. (1984b): Effect of Eugenol on Respiration and Division in Human Pulp, Mouse Fibroblasts, and Liver Cells in vitro, J Dent Res 63:1262-1265.
- Hume, W.R. (1985): A New Technique for Screening Chemical Toxicity to the Pulp from Dental Restorative Materials and Procedures, J Dent Res 64:1322-1325.[Abstract/Free Full Text]
- Kawahara, H.; Imanishi, Y.; and Oshima, H. (1979): Biological Evaluation on Glass Ionomer Cement, J Dent Res 58:1080-1086.[Abstract/Free Full Text]
- McLean, J.W. (1984): Alternatives to Amalgam Alloys: 1, Br Dent J 157:432-433.[Medline]
[Order article via Infotrieve]
- Meryon, S.D.; Stephens, P.G.; and Browne, R.M. (1983): Comparison of the in vitro Cytotoxicity of Two Glass Ionomer Cements, J Dent Res 62:769-773.[Abstract/Free Full Text]
- Mjor, LA (1980): Pre-clinical Requirements in the Evaluation of Dental Materials. Clinical Evaluation of the Dental Materials. Publication 80-1147 of the N.I.H., pp. 3-8.
- Nordenval, K.J.; Brannstrom, M.; and Torstenson, B. (1979): Pulp Reactions and Microorganisms under ASPA and Concise Composite Fillings, J Dent Child 46:449-453.[Medline]
[Order article via Infotrieve]
- Pameijer, C.H.; Segal, E.; and Richardson, J. (1981): Pulpal Response to a Glass Ionomer Cement in Primates, J Prosthet Dent 46:36-40.[CrossRef][Medline]
[Order article via Infotrieve]
- Plant, G.C.; Browne, R.M.; Knibbs, P.J.; Britton, A.S.; and Sorahan, T. (1984): Pulpal Effects of Glass Ionomer Cements, Int Endod J 17:51-59.[Medline]
[Order article via Infotrieve]
- Smith, D.C. and Ruse, N.D. (1986): Acidity of Glass Ionomer Cements During Setting and its Relation to Pulp Sensitivity, JAm Dent Assoc 112:654-657.
- Tobias, R.S.; Browne, R.M.; Plant, G.C.; and Ingram, D.V. (1978): Pulpal Response to a Glass Ionomer Cement, Br Dent J 144:345-350.[CrossRef][Medline]
[Order article via Infotrieve]
- Travis, B.J. (1977): Statistical Evaluation of Experimental Data. In: Animal Models in Dental Research, J.M. Navia, Ed., Birmingham: The University of Alabama Press, pp. 45-47 and 409.
- Ucok, M. (1986): Biological Evaluation of Glass Ionomer Cements, Int Endod J 19:285-297.[Medline]
[Order article via Infotrieve]
- Wang, J.-d. and Hume, W.R. (1988): Diffusion of Hydrogen Ion and Hydroxyl Ion from Various Sources through Dentine, Int Endod J 21:17-26.[Medline]
[Order article via Infotrieve]
- Wennberg, A. (1976): An in vitro Method for Toxicity Evaluation of Water Soluble Substances, Acta Odontol Scand 34:33-41.[CrossRef][Medline]
[Order article via Infotrieve]
Journal of Dental Research, Vol. 67, No. 6,
915-918 (1988)
DOI: 10.1177/00220345880670060501
 CiteULike  Complore  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter What's this?
This article has been cited by other articles:
|
|
|
|
 
H.-J. Chang, C.-M. Wu, Y.-C. Chang, J.-C. Fanchiang, D.-B. Shieh, and T.-Y. Wong
Collagen Enhances Compatibility and Strength of Glass Ionomers
Journal of Dental Research,
May 1, 2009;
88(5):
449 - 454.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Xie, J.-G. Park, M. Faddah, J. Zhao, and H. K. Khanijoun
Novel Amino Acid-constructed Polyalkenoates for Dental Glass-ionomer Restoratives
J Biomater Appl,
October 1, 2006;
21(2):
147 - 165.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D. Xie, I.-D. Chung, G. Wang, and J. Mays
Synthesis and Evaluation of Novel Bifunctional Oligomer-based Composites for Dental Applications
J Biomater Appl,
January 1, 2006;
20(3):
221 - 236.
[Abstract]
[PDF]
|
|
|
|
|
|
|
G. Bergenholtz
Evidence for Bacterial Causation of Adverse Pulpal Responses in Resin-Based Dental Restorations
Critical Reviews in Oral Biology & Medicine,
January 1, 2000;
11(4):
467 - 480.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. R. Stanley
Local and Systemic Responses To Dental Composites and Glass Ionomers
Advances in Dental Research,
September 1, 1992;
6(1):
55 - 64.
[Abstract]
[PDF]
|
|
|
|
|
