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Differential Modulation of Adherence of Oral Streptococci by Human Neutrophil Myeloperoxidase

Section of Periodontics, Center for the Health Sciences, University of California, Los Angeles, California 90024, Section of Oral Biology, School of Dentistry, Center for the Health Sciences, University of California, Los Angeles, California 90024

P.M. de Camargo

Section of Periodontics, Center for the Health Sciences, University of California, Los Angeles, California 90024

L.E. Wolinsky

Section of Oral Biology, School of Dentistry, Center for the Health Sciences, University of California, Los Angeles, California 90024

In this study, the modulation of adherence of hydrogen peroxide (H₂O₂)-producing and non-H₂O₂-producing strains of oral streptococci by the host leukocyte enzyme myeloperoxidase (MPO) was examined. It was found that exposure to MPO decreased adherence of many strains of oral streptococci to saliva-coated hydroxyapatite beads in the presence of exogenous H₂O ₂ and chloride. The MPO-H₂O₂-Cl^- system increased the adherence of one strain. In the absence of exogenous H ₂O₂, the MPO-H₂O₂-Cl^- system decreased the adherence of H₂O₂producing strains only. Glucose increased streptococcal H₂O₂ production and also increased the anti-adhesive activity of MPO in the absence of exogenous H₂O₂. We conclude that: (1) host leukocytes can modulate the adherence of oral streptococci via MPO; (2) endogenous production of H ₂O₂ by the oral streptococci can provide sufficient substrate H₂O₂ to drive this system; and (3) MPO will exert differential modulatory effects on the adherence of oral streptococci, based in part upon the level of endogenous H₂O₂ production and in part upon the particular characteristics of the adhesins of the bacteria.

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Journal of Dental Research, Vol. 67, No. 10, 1300-1306 (1988)
DOI: 10.1177/00220345880670101101


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Miyasaki, K.T. Articles by Wolinsky, L.E. Search for Related Content PubMed PubMed Citation Articles by Miyasaki, K.T. Articles by Wolinsky, L.E. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB CALCIUM COMPOUNDS GLUCOSE HYDROGEN PEROXIDE HYDROXYAPATITE Social Bookmarking                         What's this?