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Journal of Dental Research
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Comparison of Fluoride Concentrations in Unstimulated whole Saliva Following the Use of a Fluoride Dentifrice and a Fluoride Rinse

D.T. Zero

Eastman Dental Center, 625 Elmwood Avenue, Rochester, New York 14620

J. Fu

Eastman Dental Center, 625 Elmwood Avenue, Rochester, New York 14620

M.A. Espeland

Center for Prevention Research and Biometry, Bowman-Gray School of Medicine, 300 S. Hathorne Road, Winston-Salem, North Carolina 27103

J.D.B. Featherstone

Eastman Dental Center, 625 Elmwood Avenue, Rochester, New York 14620

Recent evidence has suggested that the cariostatic effects of topical fluoride (F) are related to the presence of low concentrations of ionic F in the oral environment. The purpose of this study was to compare the retention of F in the oral environment over 24-hour periods after the use of a F dentifrice or a F rinse.

Groups of ten consenting adult subjects (age 18-52 years) brushed and/or rinsed (B/R) in a standardized manner twice per day in the morning (AM) and before bed (PM) with either a placebo dentifrice (8 ppm F), NaF dentifrice (1100 ppm F), or NaF rinse (225 ppm F). Experiments were performed with placebo dentifrice only (PD); F dentifrice only (FD); F dentifizce followed by F rinse (FD/FR); placebo dentifrice followed by F rinse (PD/FR); and F rinse followed by placebo dentifrice (FR/PD). Unstimulated whole saliva samples were collected at baseline and then at 0, 15, 30, and 45 min, 1, 2, and 8 hr after B/R in the AM, after B/R in the PM and upon rising the following morning. Salivary flow rate and F were determined for each sampling interval.

The results of this study suggest that: (1) F rinse may be a more effective way of delivering topical F than F dentifrice; (2) based on F retention, the combination of FD/FR was not more effective than FR only (PD/FR); (3) older individuals with gingival recession retained higher F levels; and (4) bedtime F application resulted in longer F retention than did daytime application, which may have important implications for enamel remineralization.

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Journal of Dental Research, Vol. 67, No. 10, 1257-1262 (1988)
DOI: 10.1177/00220345880670100201
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