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Journal of Dental Research
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Gallotannins Inhibit Growth, Water-insoluble Glucan Synthesis, and Aggregation of Mutans Streptococci

C.D. Wu-Yuan

Department of Biological Sciences, Chicago State University, 95th Street and King Drive, Chicago, Illinois 60628

C.Y. Chen

c/o Dr. R. T. Wu, Graduate Institute of Microbiology and Immunology, National Yang-Ming Medical College, Taipei, Taiwan

R.T. Wu

c/o Dr. R. T. Wu, Graduate Institute of Microbiology and Immunology, National Yang-Ming Medical College, Taipei, Taiwan

During screening for anti-plaque agents of plant origin, ethanolic extracts from Melaphis chinensis (Bell), the Chinese Nutgall, exhibited strong inhibition of glucosyltransferase (GTF), in vitro adherence and glucan-induced agglutination of Streptococcus mutans 3209 and S. sobrinus B13. More than 91% inhibition of water-insoluble glucan synthesis from sucrose by GTF was noted at a concentration as low as 7.8 µg/mL. Bactericidal effects on other mutans streptococci, S. salivarius, and Actinomyces viscosus were also evident. Through chemical fractionation and analyses, along with bioassays, the active components were identified as gallotannins.

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Journal of Dental Research, Vol. 67, No. 1, 51-55 (1988)
DOI: 10.1177/00220345880670011001
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