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Physical Model for Non-steady-state Dissolution of Dental Enamel
M.V. Patel
Department of Pharmaceutics, University of Utah, Salt Lake City, Utah 84112
J.L. Fox
Department of Pharmaceutics, University of Utah, Salt Lake City, Utah 84112
W.I. Higuchi
Department of Pharmaceutics, University of Utah, Salt Lake City, Utah 84112
The purpose of this study was to provide a rigorous theoretical understanding of the dissolution behavior of dental enamel over the entire time-course of demineralization and to simulate by computer an erosion-type caries lesion according to the physical "hydroxyapa tite model".
The appropriate diffusion equations which accountfor simultaneous diffusion and equilibrium of all species in enamel pores, boundary layer, and bulk solution, and which also take into consideration surface reaction kinetics, were employed to allow for calculation of the micro-environmental solution concentration and changes in the mineral density as a function of time and distance within the enamel. This comprehensive physical model for non-steady-state enamel dissolution also explicitly takes into account changes in the diffusivity and the dissolution rate constant as a function of mineral density. Demineralization experiments were conducted in 0.1 mol/L sink acetate buffer (pH = 4.50, µ= 0.50), with ground bovine dental enamel blocks of known surface area mounted (with beeswax) in a rotating disk apparatus. Mineral density profiles were quantified by means of contact x-ray microradiography. The physical model was used to predict mineral density profiles for given demineralization treatments. The experimental profiles agreed quite well with the predicted profiles, when the effective diffusivity of the enamel was assumed to be a function of porosity and when changes in surface area of the crystallites were taken into consideration.
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Journal of Dental Research, Vol. 66, No. 9,
1418-1424 (1987)
DOI: 10.1177/00220345870660090201
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