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Morphological Changes of Intercellular Junctions in the Rat Submandibular Gland Treated by Long-term Repeated Administration of Isoproterenol

2nd Department of Pathology, Tokyo Dental College, 1-2-2 Masago, Chiba-shi, Chiba 260, Japan

H. Yamane

2nd Department of Pathology, Tokyo Dental College, 1-2-2 Masago, Chiba-shi, Chiba 260, Japan

T. Yamamura

2nd Department of Pathology, Tokyo Dental College, 1-2-2 Masago, Chiba-shi, Chiba 260, Japan

M. Shimono

2nd Department of Pathology, Tokyo Dental College, 1-2-2 Masago, Chiba-shi, Chiba 260, Japan

Long-term repeated administration of isoproterenol (lPR) 2 mg/100 g bw, once daily for ten days, resulted in morphological changes in the intercellular junctions of rat submandibular glands, which were investigated by means of the freeze fracture technique. A significantly increased number of tight-junctional strands was present. These junctional strands extended much deeper toward the basal membrane than those in normal acinar cells. The basal frontier strands that branched from the networks of tight junctions were elongated and had either free-endings or terminal loops, which were more frequently observed in the IPR-treated acinar cells than in untreated acinar cells. Some of the strands of tight junctions were connected to small gap junctions. The diameters of gap junctions were not significantly different from those of control acinar cells. However, smooth areas devoid of particles were found intermingling with the usual packed particles in irregularly shaped small gap junctions. There was no significant difference between the desmosomes of IPR-treated and untreated acinar cells, in terms of either morphology or distribution. These changes in junctional morphology in the IPR-treated acinar cells resemble those seen in salivary glands during development, and in some experimental conditions including tumorous changes.

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Journal of Dental Research, Vol. 66, No. 8, 1303-1309 (1987)
DOI: 10.1177/00220345870660080301


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Inoue, T. Articles by Shimono, M. Search for Related Content PubMed PubMed Citation Articles by Inoue, T. Articles by Shimono, M. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Social Bookmarking                         What's this?