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Effects of Eugenol on Polymorphonuclear Cell Migration and Chemiluminescence

Department of Oral Diagnosis and Radiology, West Virginia University School of Dentistry, Department of Medical Microbiology, West Virginia University School of Dentistry

C.J. Woolverton

Department of Medical Microbiology, West Virginia University School of Medicine, West Virginia University Medical Center, Morgantown, West Virginia 26506

K. Van Dyke

Department of Pharmacology and Toxicology, West Virginia University School of Medicine, West Virginia University Medical Center, Morgantown, West Virginia 26506

R.L. Powell

Department of Oral Diagnosis and Radiology, West Virginia University School of Dentistry

In this study, the effects of eugenol on human polymorphonuclear (PMN) cell migration and chemiluminescence were examined in vitro. Utilizing zymosan-activated serum or crude Bacteroides sonicate fractions as chemotractants, we found that eugenol inhibits PMN migration at 6.6 x 10^-2 to 6.6 x 10^-5 mol/L (P<0.05). Also, similar effects were observed in PMNs pre-incubated in eugenol. Regardless of concentration, eugenol was not found to induce chemotaxis of PMNs. An examination of PMN membrane activation through chemiluminescence gave results consistent with the chemotaxis data, demonstrating a decrease in light emission at concentrations as low as 6.6 x 10-6 mol/L (P<0.05). In view of these data, the potential effect of eugenol on in vivo (sulcular or periapical) PMN function deserves further study.

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Journal of Dental Research, Vol. 66, No. 3, 774-777 (1987)
DOI: 10.1177/00220345870660031401


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Fotos, P.G. Articles by Powell, R.L. Search for Related Content PubMed PubMed Citation Articles by Fotos, P.G. Articles by Powell, R.L. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB EUGENOL Social Bookmarking                         What's this?