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In vitro Modulation of T6 Expression on Gingival Langerhans Cells by Interleukin-1 Inhibitors and ETAF

Department of Social and Preventive Dentistry, University of Queensland Dental School, Turbot Street, Brisbane, QLD 4000, Australia

P.E. Lander

Department of Social and Preventive Dentistry, University of Queensland Dental School, Turbot Street, Brisbane, QLD 4000, Australia

G.J. Seymour

Department of Social and Preventive Dentistry, University of Queensland Dental School, Turbot Street, Brisbane, QLD 4000, Australia

R.N. Powell

Department of Social and Preventive Dentistry, University of Queensland Dental School, Turbot Street, Brisbane, QLD 4000, Australia

T6 antigen is a highly specific marker for human Langerhans cells (LC). Previous studies have demonstrated that Interleukin-1 (IL-1) and an IL-1 inhibitor (ILS) modulate LC T6 expression (T6E) in explant culture. The present study examined the in vitro modulation of T6E by two molecules: epidermal-cell-derived thymocyte-activating factor (ETAF), and a bone-derived protein (BP) implicated in the control of bone homeostasis. The effect of purified ILS was also examined. ETAF mimicked the stimulatory effect of IL-1 on LC T6E, while BP depressed T6E in a manner resembling that seen with ILS. No agents altered Class II (DR and DQ) expression by LC. BP was a specific IL-1 inhibitor, and did not inhibit thymocyte proliferation in the standard IL-1 bioassay in the absence of IL-1. These results demonstrate that molecules resembling IL-1 or ILS can modulate T6E, and implicate locally produced ETAF and ILS in the regulation of T6E in the oral mucosa in vivo.

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Journal of Dental Research, Vol. 66, No. 3, 766-769 (1987)
DOI: 10.1177/00220345870660031201


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Walsh, L.J. Articles by Powell, R.N. Search for Related Content PubMed PubMed Citation Articles by Walsh, L.J. Articles by Powell, R.N. Social Bookmarking                         What's this?