Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Abe, K.
Right arrow Articles by Matsumoto, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Abe, K.
Right arrow Articles by Matsumoto, M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Developmental Changes in the Volumes, Protein, and Some Electrolyte Concentrations of Male and Female Rat Submandibular Saliva Secreted in Response to Methoxamine and Pilocarpine

K. Abe

Department of Oral Biochemistry, Fukuoka Dental College, 700, Ta, Sawara-ku, Fukuoka-shi, 814-01, Japan

S. Hidaka

Department of Oral Biochemistry, Fukuoka Dental College, 700, Ta, Sawara-ku, Fukuoka-shi, 814-01, Japan

K. Ishibashi

Department of Oral Biochemistry, Fukuoka Dental College, 700, Ta, Sawara-ku, Fukuoka-shi, 814-01, Japan

M. Yanabu

Department of Orthodontics, Fukuoka Dental College, 700, Ta, Sawara-ku, Fukuoka-shi, 814-01, Japan

K. Kamogashira

Department of Orthodontics, Fukuoka Dental College, 700, Ta, Sawara-ku, Fukuoka-shi, 814-01, Japan

T. Itoh

Department of Orthodontics, Fukuoka Dental College, 700, Ta, Sawara-ku, Fukuoka-shi, 814-01, Japan

M. Matsumoto

Department of Orthodontics, Fukuoka Dental College, 700, Ta, Sawara-ku, Fukuoka-shi, 814-01, Japan

Saliva secreted in response to methoxamine and pilocarpine was collected from the cannulated ducts of the submandibular glands of male and female rats at weekly intervals from two to 10 weeks of age. It was analyzed for volume and for concentrations of protein, potassium, calcium, and inorganic phosphate. Following the collection of saliva, the submandibular glands were removed and weighed.

The wet weights of the glands increased substantially up to seven weeks of age and then reached almost plateau values in both sexes. The salivary volumes secreted in response to both agents in both sexes were positively correlated with the gland weights, except that after five to six weeks of age there was no correlation between gland weight and methoxamine-stimulated salivary volume. The concentrations of protein, potassium, and inorganic phosphate were inversely related to the flow rates only at relatively low rates of flow. The concentration of calcium was positively correlated with the protein concentration and was independent of the nature of the stimulus and of sex differences during postnatal development.

REFERENCES

  • Abe, K. and Dawes, C. (1978): The Effects of Electrical and Pharmacological Stimulation on the Types of Proteins Secreted by Rat Parotid and Submandibular Glands, Arch Oral Biol 23:367-372.[CrossRef][Medline] [Order article via Infotrieve]
  • Abe, K. and Dawes, C. (1980): The Secretion of Protein and of Some Electrolytes in Response to a- and β-Adrenergic Agonists by Rat Parotid and Submandibular Salivary Glands Enlarged by Chronic Treatment with Isoproterenol, J Dent Res 59:1081-1089.[Abstract/Free Full Text]
  • Abe, K. and Dawes, C. (1982): Dopamine-induced Secretion of Protein and of Some Electrolytes by Rat Submandibular and Parotid Gland, Arch Oral Biol 27:635-643.[CrossRef][Medline] [Order article via Infotrieve]
  • Abe, K. and Dawes, C. (1984): The Effects of a-Methylnoradrenaline on Protein and Electrolyte Secretion by Rat Submandibular and Parotid Glands, Comp Biochem Physiol 78C:383-389.
  • Abe, K. and Dawes, C. (1985): The Effects of Oxymetazoline on Secretion of Protein and Some Electrolytes by Rat Submandibular and Parotid Glands, Comp Biochem Physiol 80C:347-353.[CrossRef][Medline] [Order article via Infotrieve]
  • Abe, K.; Oikawa, M.; Abe, S.; and Takada, N. (1982): The Effects of Pilocarpine on Protein Concentration of the Submandibular Saliva of Rats, J Gifu Dent Soc 10:242-252.
  • Abe, K.; Oikawa, M.; and Abe, S. (1983): Rate of Protein Excretion of Rat Submandibular and Parotid Saliva Elicited by Different Stimuli, J Gifu Dent Soc 10:460-471.
  • Alvares, E.P. and Sesso, A. (1975): Cell Proliferation, Differentiation and Transformation in the Rat Submandibular Gland During Early Postnatal Growth. A Quantitative and Morphological Study, Arch Histol Jpn 38:177-208.[Medline] [Order article via Infotrieve]
  • Ball, W.D. and Redman, R.S. (1984): Two Independently Regulated Secretory Systems Within the Acini of the Submandibular Gland of the Perinatal Rat, Eur J Cell Biol 33:112-122.[Medline] [Order article via Infotrieve]
  • Barrett, M.L. and Ball, W.D. (1974): Development of the Rat Salivary Glands. II. The Identification of a Trypsinlike Protease in the Submaxillary Gland, Devel Biol 36:195-201.[CrossRef][Medline] [Order article via Infotrieve]
  • Bellavia, S.L.; Moreno, J.; Sanz, E.; Picas, E.J.; and Blanco, A. (1979): a-Amylase Activity of Human Neonatal and Adult Saliva, Arch Oral Biol 24:117-121.[Medline] [Order article via Infotrieve]
  • Butcher, F.R. (1978): Calcium and Cyclic Nucleotides in the Regulation of Secretion from the Rat Parotid by Autonomic Agonists, Adv Cyclic Nucleotide Res 9:707-721.[Medline] [Order article via Infotrieve]
  • Bylund, D.B.; Martinez, J.R.; Camden, J.; and Jones, S.B. (1982): Autonomic Receptors in the Developing Submandibular Glands of Neonatal Rats, Arch Oral Biol 27:945-950.[CrossRef][Medline] [Order article via Infotrieve]
  • Chen, P.S.; Toribara, T.Y.; and Warner, H. (1956): Micro-determination of Phosphorus, Anal Chem 28:1756-1758.
  • Chang, W.W.L. (1974): Cell Population Changes During Acinus Formation in the Postnatal Rat Submandibular Gland, Anat Rec 178:187-202.[CrossRef][Medline] [Order article via Infotrieve]
  • Cutler, L.S. and Chaudhry, A.P. (1974): Cytodifferentiation of the Acinar Cells of the Rat Submandibular Gland, Devel Biol 41:31-41.[Medline] [Order article via Infotrieve]
  • Cutler, L.S. and Chaudhry, A.P. (1975): Cytodifferentiation of Striated Duct Cells and Secretory Cells of the Convoluted Granular Tubules of the Rat Submandibular Gland, Am J Anat 143:201-217.[CrossRef][Medline] [Order article via Infotrieve]
  • Cutler, L.S.; Christian, C.P.; and Bottaro, B. (1981): Development of Stimulus-Secretion Coupling in Salivary Glands, Meth Cell Biol 23:531-545.[CrossRef][Medline] [Order article via Infotrieve]
  • Cutler, L.S. and Rodan, S.B. (1976): Biochemical and Cytochemical Studies on Adenylate Cyclase Activity in the Developing Rat Submandibular Gland: Differentiation of the Acinar Secretory Compartment, J Embryol Exp Morphol 36:291-303.[Medline] [Order article via Infotrieve]
  • Dawes, C. (1967): The Secretion of Magnesium and Calcium in Human Parotid Saliva, Caries Res 1:333-342.[Medline] [Order article via Infotrieve]
  • Dawes, C. (1969): The Effects of Flow Rate and Duration of Stimulation on the Concentrations of Protein and the Main Electrolytes in Human Parotid Saliva, Arch Oral Biol 14:277-294.[CrossRef][Medline] [Order article via Infotrieve]
  • Dawes, C. (1974): The Effects of Flow Rate and Duration of Stimulation on the Concentrations of Protein and the Main Electrolytes in Human Submandibular Saliva, Arch Oral Biol 19:887-895.[CrossRef][Medline] [Order article via Infotrieve]
  • Dawes, C.; Cross, H.G.; Baker, C.G.; and Chebib, F.S. (1978): The Influence of Gland Size on the Flow Rate and Composition of Human Parotid Saliva, J Can Dent Assoc 44:21-25.
  • De Champlain, J.; Malmors, T.; Olson, L.; and Sachs, C. (1970): Ontogenesis of Peripheral Adrenergic Neurons in the Rat. Pre- and Postnatal Observation, Acta Physiol Scand 80:276-288.
  • Ericson, S. (1971a): The Importance of Sialography for the Determination of the Parotid Flow. The Normal Variation in Salivary Output in Relation to the Size of the Gland at Stimulation with Citric Acid, Acta Otolaryngol 72:437-444.[Medline] [Order article via Infotrieve]
  • Ericson, S. (1971b): The Variability of the Human Parotid Flow on Stimulation with Citric Acid, with Special Reference to Taste, Arch Oral Biol 16:9-19.[CrossRef][Medline] [Order article via Infotrieve]
  • Fukuda, M. (1967): Histological Studies on the Rat Submaxillary Gland During Post-natal Development, Histochemie 8:342-354.[Medline] [Order article via Infotrieve]
  • Grand, R.J. and Schay, M.I. (1978): Development of Secretory Function in Rat Parotid Gland, Pediatr Res 12:100-104.[Medline] [Order article via Infotrieve]
  • Holzgreve, H.; Martinez, J.R.; and Vogel, A. (1966): Micropuncture and Histologic Study of Submaxillary Glands of Young Rats, Pflüger Arch 290:134-143.[CrossRef]
  • Ikeno, K.; Kuzuya, H.; and Ishiguro, I. (1984): Developmental Changes of Trypsin-like Protease Activity in the Submandibular Glands of Male and Female Young Growing Rats, Arch Oral Blol 29:669-674.
  • Inoue, H.; Hidaka, S.; and Abe, K. (1986): Developmental Changes of Secretory Responses in Young Rat Submandibular Gland, J Dent Res 65:834, Abstr. No. 977 (IADR).
  • Jacoby, F. and Leeson, C.R. (1959): The Postnatal Development of the Rat Submaxillary Gland, J Anat 93:201-216.[Medline] [Order article via Infotrieve]
  • Kim, S.K.; Han, S.S.; and Nasjleti, C.E. (1970): The Fine Structure of Secretory Granules in Submandibular Glands of the Rat During Early Postnatal Development, Anat Rec 168:463-476.[Medline] [Order article via Infotrieve]
  • Kim, S.K. and Calkins, D.W. (1983): Secretory Protein Synthesis in Parotid Glands of Young and Old Rats, Arch Oral Biol 28:1-4.[CrossRef][Medline] [Order article via Infotrieve]
  • Lagerlof, F. and Ekstrand, J. (1982): The Effects of Flow Rate on the Ionized Calcium Concentration of Human Parotid Saliva, Caries Res 16:123-128.[Medline] [Order article via Infotrieve]
  • Lowry, O.H.; Rosebrough, N.J.; Farr, A.L.; and Ran-Dall, R.J. (1951): Protein Measurement with the Folin Phenol Reagent, J Biol Chem 193:265-275.[Free Full Text]
  • Maier, H.; Triebel, C.; and Heidland, A. (1983): The FlowRate-Dependent Excretion of Ionized Calcium in Pilocarpine-Stimulated Human Submandibular Saliva, Arch Oral Biol 28:907-909.[Medline] [Order article via Infotrieve]
  • Martinez, J.R. and Camden, J. (1982): In-vitro Release of K+ from the Developing Submandibular Gland of Early Postnatal Rats, Arch Oral Biol 27:939-944.[CrossRef][Medline] [Order article via Infotrieve]
  • Mangos, J.A. (1978): Micropuncture Study of Postnatal Functional Maturation of the Rat Parotid, J Dent Res 57:826-833.[Abstract/Free Full Text]
  • Parvinen, T. and Larmas, M. (1982): Age Dependency of Stimulated Salivary Flow Rate, pH, and Lactobacillus and Yeast Concentrations, J Dent Res 61:1052-1055.[Abstract/Free Full Text]
  • Reynolds, J.M. and Pull, S.L. (1983): The Concentrations of Sodium, Potassium and Chloride in Rabbit Submandibular Saliva During Postnatal Development, Arch Oral Biol 28:879-883.[Medline] [Order article via Infotrieve]
  • Schneyer, C.A. and Schneyer, L.H. (1960): Electrolyte Levels of Rat Salivary Secretions in Relation to Fluid-Flow Rate, Am J Physiol 199:55-58.[Abstract/Free Full Text]
  • Schneyer, C.A. and Hall, H.D. (1967a): Autonomic Regulation of the Immature and Adult Rat Parotid Gland. In: Secretory Mechanisms of Salivary Glands, L.H. Schneyer and C.A. Schneyer, Eds., New York: Academic Press, pp. 155-177.
  • Schneyer, C.A. and Hall, H.D. (1967b): Effects of Denervation on Development of Function and Structure of Immature Rat Parotid, Am J Physiol 214:808-813.
  • Schneyer, C.A. and Hall, A.D. (1968): Time Course and Autonomic Regulation of Development of Secretory Function of Rat Parotid, Am J Physiol 214:808-813.[Free Full Text]
  • Schneyer, L.H.; Schneyer, C.A.; and Yoshida, Y. (1968): Membrane Potentials of Developing Cells in Immature Rat Submaxillary Gland, Am J Physiol 215:1146-1150.[Free Full Text]
  • Sreebny, L.M.; Meyer, J.; Bachem, E.; and Weinmann, J.P. (1955): Postnatal Changes in Proteolytic Activity and in the Morphology of the Submaxillary Gland in Male and Female Albino Rats, Growth 19:57-74.[Medline] [Order article via Infotrieve]
  • Srinivasan, R. and Chang, W.W.L. (1975): The Development of the Granular Convoluted Duct in the Rat Submandibular Gland, Anat Rec 182:29-40.[CrossRef][Medline] [Order article via Infotrieve]
  • Strum, J.M. (1971): Unusual Peroxidase-Positive Granules in the Developing Rat Submaxillary Gland, J Cell Biol 51:575-579.[Free Full Text]
  • Wallach, D. and Schramm, M. (1971): Calcium and the Exportable Protein in Rat Parotid Gland. Parallel Subcellular Distribution and Concomitant Secretion, Eur J Biochem 21:433-437.[Medline] [Order article via Infotrieve]
  • Windeler, A.S. and Shannon, I.L. (1967): Effects of Flow Rate on Parotid Fluid Calcium, Magnesium and Protein Concentrations in Man, Arch Oral Biol 12:1063-1069.[Medline] [Order article via Infotrieve]
  • Yamashina, S. and Barka, T. (1972): Localization of Peroxidase Activity in the Developing Submandibular Gland of Normal and Isoproterenol-treated Rats, J Histochem Cytochem 20:855-872.[Medline] [Order article via Infotrieve]
  • Yamashina, S. and Barka, T. (1974): Peroxidase Activity in the Developing Rat Submandibular Gland, Lab Invest 31:82-89.
  • Yaegaki, K.; Satake, T.; Ogura, R.; Kameyama, T.; and Sujaku, C. (1982): Influence of Aging on DNase Activity in Human Parotid Saliva, J Dent Res 61:1222-1224.[Abstract/Free Full Text]
  • Yoshida, Y.; Sprecher, R.L.; Schneyer, C.A.; and Schneyer, L.H. (1967): Role of β-Receptors in Sympathetic Regulation of Electrolytes in Rat Submaxillary Saliva, Proc Soc Exp Biol Med 126:912-916.[CrossRef]
  • Zajicek, G.; Yagil, C.; and Michaeli, Y. (1985): The Streaming Submandibular Gland, Anat Rec 213:150-158.[CrossRef][Medline] [Order article via Infotrieve]

Journal of Dental Research, Vol. 66, No. 3, 745-750 (1987)
DOI: 10.1177/00220345870660030801
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 CROBMHome page
G. S. Bedi
The Effect of Adrenergic Agonists and Antagonists on the Expression of Proteins in Rat Submandibular and Parotid Glands
Critical Reviews in Oral Biology & Medicine, January 1, 1993; 4(3): 565 - 571.
[Abstract] [Full Text] [PDF]

Home page
 JDRHome page
E. Tanaka, T. Habu, A. Letic-Gavrilovic, and K. Abe
Changes in Protein Secretion by Rat Submandibular Glands in Response to Isoproterenol, a-Methylnoradrenaline, and Clonidine during Post-natal Development
Journal of Dental Research, January 1, 1990; 69(1): 60 - 66.
[Abstract] [PDF]

Home page
 JDRHome page
A. Inanaga, T. Habu, E. Tanaka, T. Taniguch, T. Nishiura, K. Ishibashi, S. Naruse, and K. Abe
Age Changes in Secretory Function of Male and Female Rat Parotid Glands in Response to Methoxamine and Pilocarpine
Journal of Dental Research, March 1, 1988; 67(3): 565 - 573.
[Abstract] [PDF]

This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Abe, K.
Right arrow Articles by Matsumoto, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Abe, K.
Right arrow Articles by Matsumoto, M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?