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Journal of Dental Research
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The Influence of Incorporated and Adsorbed Fluoride on the Dissolution of Powdered and Pelletized Hydroxyapatite in Fluoridated and Non-fluoridated Acid Buffers

L. Wong

Dental Research Unit, Medical Research Council, P.O. Box 27007, Wellington, New Zealand

T.W. Cutress

Dental Research Unit, Medical Research Council, P.O. Box 27007, Wellington, New Zealand

J.F. Duncan

Chemistry Department, Victoria University of Wellington, Wellington, New Zealand

The effects of fluoride (F) incorporated into hydroxyapatite (HA), adsorbed onto the HA surface, and fluoride in solution were studied during HA dissolution. Dissolution rates at pH 5. and 25°C were determined in fluoridated (0.1, 5.0 µg/mL) and non-fluoridated buffers for the following powdered and pelletized synthesized HAs: non-fluoridated HA, partially-fluoridated (100, 1000, 37,000 µglg) HA, and surface-adsorbed fluoridated (100, 1000 µg/g) HA. The dissolution rate curves were used to derive two components we have called 'diffusion' and 'surface chemical reactivity'. With powders, the rate-determining factor was surface chemical reactivity during the first 60 min. Diffusion was reduced by increasing the F levels in the apatite or buffer. In non-fluoridated buffers, diffusion was reduced 29% for apatite with 100 µg/g incorporated F and 99% with 37,000 µg/g-Diffusion was reduced by 37% and 81 % by 0.1 and 5.0 µg/mL F, respectively, in the buffer. With pelletized HA, the rate-determining factor during the first 10 min was surface chemical reactivity. Diffusion then became relatively more important, but the diffusion rate was independent of F content. During the dissolution of powdered apatites, F was taken up by the remaining apatite solid, as evidenced by the lower F concentration in solution than that calculated to be released during dissolution. There was also a decrease in the F concentration of the 0.1 µg/mL buffer as reaction progressed. Pelletized apatites did not release enough F to influence dissolution significantly. Surface-adsorbed F was more effective than incorporated F in reducing HA dissolution. However, solution F present at the apatite surface in small concentrations (<5.0 µg/mL) was more effective than much higher concentrations (1000 µg/g) of adsorbed or incorporated F in reducing dissolution.

REFERENCES

  • American Society for Testing and Materials ( 1969): Inorganic Index to the Powder Diffraction File, Philadelphia: pp. 648-649.
  • Arends, J.; Nelson, D.G.A.; Dijkman, A.G.; and Jongebloed, W.L. (1984): Effect of Various Fluorides on Enamel Structure and Chemistry. In: Cariology Today, Int. Congr., Zurich (1983), B. Guggenheim, Ed., Basel: Karger, pp. 245-258.
  • Barton, A.F.M. and McConnel, S.R. (1979): Dissolution Behavior of Solids: The Rotating Disc Method, Chem Aust 46:427-433.
  • Chander, S.; Chiao, C.C.; and Fuerstenau, D.W. (1982): Transformation of Calcium Fluoride for Caries Prevention, J Dent Res 61:403-407.[Abstract/Free Full Text]
  • Chen, P.S.; Toribara, T.Y.; and Warner, H. (1956): Micro-determination of Phosphorus, Anal Chem 28:1756-1758.
  • Dijkman, A.G.; Tak, J.; and Arends, J. (1982): Fluoride Deposited by Topical Applications in Enamel, Caries Res 16:147-155.[Medline] [Order article via Infotrieve]
  • Driessens, F.C.M. (1973a): Relation between Apatite Solubility and Anti-cariogenic Effect of Fluoride, Nature 243:420-421.[CrossRef][Medline] [Order article via Infotrieve]
  • Driessens, F.C.M. (1973b): Fluoride Incorporation and Apatite Solubility, Caries Res 7:297-314.[Medline] [Order article via Infotrieve]
  • Duff, E.J. (1973): Orthophosphates XIV. Thermodynamical Factors Influencing the Stability of Dental Enamel to Decay, Caries Res 7:70-78.[Medline] [Order article via Infotrieve]
  • Featherstone, J.D.B.; Duncan, J.F.; and Cutress, T.W. (1979): A Mechanism for Dental Caries based on Chemical Processes and Diffusion Phenomena during in-vitro Caries Simulation in Human Tooth Enamel, Arch Oral Biol 24:101-112.[CrossRef][Medline] [Order article via Infotrieve]
  • Featherstone, J.D.B.; Shields, C.P.; Khademazad, B.; and Oldershaw, M.D. (1983): Acid Reactivity of Carbonated Apatites with Strontium and Fluoride Substitutions, J Dent Res 62:1049-1053.[Abstract/Free Full Text]
  • Forward, G.C. (1977): A New Method of Measuring Hydroxyapatite Dissolution Rate, Caries Res 11:9-15.[Medline] [Order article via Infotrieve]
  • Glass, R.L. (1982): The First International Conference on the Declining Prevalence of Dental Caries, J Dent Res 61 (Sp Iss): 1304.
  • Gray, J.A.; Francis, M.D.; and Griebstein, W.J. (1962): Chemistry of Enamel Dissolution. In: Chemistry and Prevention of Dental Caries, R.F. Sognnaes, Ed., Springfield: Charles C. Thomas Publisher, pp. 164-179.
  • Gregg, S.J. and Sing, K.S.W. (1967): Adsorption, Surface Area and Porosity, London: Academic Press, pp. 339-343.
  • Hardwick, J.L.; Teasdale, J.; and Bloodworth, G. (1982): Caries Increments over 4 years in Children aged 12 at the Start of Water Fluoridation, Br Dent J 153:217-222.[CrossRef][Medline] [Order article via Infotrieve]
  • Jordan, W. (1962): The Austin School Health Study. Dental Health, Am J Public Health 52:301-303.
  • Kunzel, W. (1980): Effect of an Interruption in Water Fluoridation on the Caries Prevalence of Primary and Secondary Dentition, Caries Res 14:304-310.[Medline] [Order article via Infotrieve]
  • Lemke, C.W.; Doherty, J.M.; and Arra, M.C. (1970): Controlled Fluoridation; the Dental Effects of Discontinuation in Antigo, Wisconsin, J Am Dent Assoc 8:782-786.
  • Leverett, D.H. (1982): Fluorides and the Changing Prevalence of Dental Caries, Science 217:26-30.[Abstract/Free Full Text]
  • Lin, J.; Raghavan, S.; and Fuerstenau, D.W. (1981): The Adsorption of Fluoride Ions by Hydroxyapatite from Aqueous Solution, Colloids Surf 3:357-370.[CrossRef]
  • Ludwig, A.; Dave, S.C.; Higuchi, W.I.; and Fox, J.L. (1982): Influence of Fluoride Ions on the Dissolution Kinetics of Apatite Powders, J Pharm Belg 37:141-149.
  • McCann, H.G. (1968): The Solubility of Fluorapatite and its Relationship to that of Calcium Fluoride, Arch Oral Biol 13:987-1001.[CrossRef][Medline] [Order article via Infotrieve]
  • Mellberg, J.R.; Laakso, P.V.; and Nicholson, C.R. (1966): The Acquisition and Loss of Fluoride by Topical Fluoridated Human Tooth Enamel, Arch Oral Biol 11:1213-1220.[CrossRef][Medline] [Order article via Infotrieve]
  • Moreno, E.C.; Kresak, M.; and Zahradnik, R.T. (1974): Fluoridated Hydroxyapatite Solubility and Caries Formation, Nature 247:64-65.[CrossRef][Medline] [Order article via Infotrieve]
  • Murray, J.J. (1986): Appropriate Use of Fluorides for Human Health, Geneva: World Health Organisation.
  • Nelsen, F.M. and Eggertsen, F.T. (1958): Determination of Surface Area. Adsorption Measurements by a Continuous Flow Method, Anal Chem 30:1387-1390.
  • Nelson, D.G.A. and Featherstone, J.D.B. (1982): Preparation, Analysis, and Characterization of Carbonated Apatites, Calcif Tissue Int 34:S69-S81.[Medline] [Order article via Infotrieve]
  • Nelson, D.G.A.; Featherstone, J.D.B.; Duncan, J.F.; and Cutress, T.W. (1983): Effect of Carbonate and Fluoride on the Dissolution Behaviour of Synthetic Apatites, Caries Res 17:200-211.[Medline] [Order article via Infotrieve]
  • Nelson, D.G.A.; Jongebloed, W.L.; and Arends, J. (1984): Crystallographic Structure of Enamel Surfaces Treated with Topical Fluoride Agents: TEM and XRD Considerations, J Dent Res 63:6-12.[Abstract/Free Full Text]
  • Okazaki, M.; Aoba, T.; Doi, Y.; Takahashi, J.; and Moriwaki, Y. (1981a): Solubility and Crystallinity in Relation to Fluoride Content of Fluoridated Hydroxyapatites, J Dent Res 60:845-849.[Free Full Text]
  • Okazaki, M.; Moriwaki, Y.; Aoba, T.; Doi, Y.; and Takahashi, J. (1981b): Dissolution Rate Behavior of Fluoridated Apatite Pellets, J Dent Res 60:1907-1911.[Abstract/Free Full Text]
  • Perrin, D.D. and Dempsey, B. (1974): Buffers for pH and Metal Ion Control, London: Chapman and Hall, pp. 62-76.
  • Ramsey, A.C.; Duff, E.J.; Paterson, L.; and Stuart, J.L. (1973): The Uptake of F- by Hydroxyapatite at Varying pH, Caries Res 7:231-244.[Medline] [Order article via Infotrieve]
  • Renson, C.E.; Crielaers, P.J.A.; Ibikunle, S.A.J.; Pinto, V.G.; Ross, C.B.; Sardo Infirri, J.; Takazoe, I.; and Tala, H. (1985): Changing Patterns of Oral Health and Implications for Oral Health Manpower: Part I, Int Dent J 35:235-251.[Medline] [Order article via Infotrieve]
  • Speake, J.D.; Cutress, T.W.; and Ball, M.E. (1979): The Prevalence of Dental Caries and the Concentration of Fluoride in the Enamel of the Children of the South Pacific, NZ Dent J 75:94-106.
  • Thylstrup, A.; Bille, J.; and Bruun, C. (1982): Caries Prevalence in Danish Children living in Areas with Low and Optimal Levels of Natural Water Fluoride, Caries Res 16:413-420.[Medline] [Order article via Infotrieve]
  • Voegel, J.C. and Garnier, P. (1979): Biological Apatite Crystal Dissolution, J Dent Res 58(B):852-856.[Abstract/Free Full Text]

Journal of Dental Research, Vol. 66, No. 12, 1735-1741 (1987)
DOI: 10.1177/00220345870660120801
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