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Immunocytochemical Evidence for the Coexistence of Catecholestrogen and Catechol-O-methyltransferase in the Rat Parotid Gland

Department of Oral Anatomy, School of Dentistry, Okayama University, Okayama 700, Japan

I. Yoshizawa

Hokkaido Institute of Pharmaceutical Science, Otaru 047, Japan

C.R. Creveling

Laboratory of Bio-organic Chemistry, NIDDK, NIH, Bethesda, Maryland 20892

Catechol-O-methyltransferase (COMT) (EC 2.1.1.6) and catecholestrogen were localized in the parotid gland of the rat by immunocytochemical methods. Specific immunoreactive deposits for COMT and catecholestrogen were found in the cytoplasm of duct cells, but only those for COMT in myo-epithelial cells. The pattern of localization of COMT and catecholestrogen in the parotid gland suggests a functional relationship between COMT and catecholestrogen.

REFERENCES

• Almgren, O. and Jonason, J. (1976): Extraneuronal Amine Transport in Glandular Tissue. In: The Mechanism of Neuronal and Extraneuronal Transport of Catecholamines, D.M. Paton, Ed., New York: Raven Press, pp. 299-311.
• Ball, P.; Haupt, M.; and Knuppen, R. (1978): Comparative Studies on the Metabolism of Oestradiol in the Brain, the Pituitary and the Liver of the Rat, Acta Endocrinol 98:1-11.
• Ball, P. and Knuppen, R. (1980): Catecholestrogens (2- and 4-hydroxy-oestrogens) Chemistry, Biogenesis, Metabolism, Occurrence and Physiological Significance, Acta Endocrinol 93 (Supp. 232):1-127.[Abstract/Free Full Text]
• Creveling, C.R.; Dalgard, N.; Shimizu, H.; and Daly, J.W. (1970): Catechol-O-methyltransferase III. m- and p-O-methylation of Catecholamines and Their Metabolites, Mol Pharmacol 6:691-696.[Abstract/Free Full Text]
• Creveling, C.R.; Morris, N.; Shimizu, H.; Ong, H.H.; and Daly, J.W. (1972): Catechol-O-methyltransferase IV: Factors Affecting m- and p-O-methylation of Substituted Catechols, Mol Pharmacol 8:398-409.[Abstract/Free Full Text]
• Davies, I.J.; Naftolin, F.; Ryan, K.J.; Fishman, J.; and Siu, J. (1975): The Affinity of Catechol Estrogens for Estrogen Receptors in the Pituitary and Anterior Hypothalamus of the Rat, Endocrinology 97:554-557.[Abstract/Free Full Text]
• Ferguson, D.B. (1984): Physiological Considerations in the Use of Salivary Steroid Estimation for Clinical Investigations. In: Steroid Hormones in Saliva, Front Oral Physiol 5, D.B. Ferguson, Ed., Basel: Karger, pp. 1-20.
• Fujiwara, M.; Tanaka, C.; Honjo, T.; and Okegawa, T. (1965): Histochemical Demonstration of Noradrenalin in Rat Salivary Glands, Jpn J Pharmacol 15:369-372.[Medline] [Order article via Infotrieve]
• Grossman, M.H.; Creveling, C.R.; Rybcynski, R.; Braver-Man, M.; Isersky, C.; and Breakfield, X.O. (1985): Soluble and Particulate Forms of Rat Catechol-O-methyltransferase Distinguished by Gel Electrophoresis and Immune Fixation, J Neurochem 44:421-432.[CrossRef][Medline] [Order article via Infotrieve]
• Hasegawa, J.; Hashimoto, S.; Nemoto, K.; Ikeno, T.; and Kuzuya, H. (1978): Catecholamine Metabolism in Salivary Gland of the Rats. 5. Developmental Changes in Catecholamine, Normetanephrine and Metanephrine Contents, J Tohoku Dent Univ 5:36-40.
• Heydorn, W.E.; Creed, G-J.; Creveling, C.R.; and Jacobowitz, D.M. (1986): Studies on Catechol-O-methyltransferase in Rat Brain using Two-dimensional Gel Electrophoresis, Neurochem Int 8:581-586.
• Inoue, K.; Creveling, C.R.-; and Tice, L-W. (1982): Immunocytochemical Localization of Catechol-O-methyltransferase in Rat Parotid Gland, Proc Soc Exp Biol Med 171:65-71.[CrossRef][Medline] [Order article via Infotrieve]
• Inoue, K.; Tice, L.W.; and Creveling, C.R. (1977): Immunocytochemical Localization of Catechol-O-methyltransferase. In: Structure and Function of Monoamine Enzymes, E. Usdin, N. Weiner, and M.B.H. Youdim, Eds., New York: Dekker, pp. 835-859.
• Inoue, K.; Tice, L.W.; and Creveling, C.R. (1980): Immunocytochemical Localization of Catechol-O-methyltransferase in the Pregnant Rat Uterus, Endocrinology 107:1833-1840.[Abstract/Free Full Text]
• Inoue, K. and Yoshizawa, I. (1985): Immunocytochemical Localization of Catechol Estrogen in the Rat Liver After Using Various Fixatives, Acta Histochem Cytochem 18:597-603.
• Inoue, K. and Yoshizawa, I. (1986): Immunocytochemical Localization of Catechol Estrogen in the Rat Pituitary Gland. I. Posterior Lobe, Acta Histochem Cytochem 19:767-774.
• Isobe, Y.; Chen, S.-T.; Nakane, P.K.; and Brown, W.R. (1977): Studies on Translocation of Immunoglobulins Across Intestinal Epithelium. I. Improvements in the Peroxidase-labeled Antibody Method for Application to Study of Human Intestinal Mucosa, Acta Histochem Cytochem 10:161-171.
• Kirchoff, J.; Hornung, E.; Ghraf, R.; Ball, P.; and Kuppen, R. (1981): Interactions of Catecholestrogens with Cytoplasmic and Nuclear Estrogen Receptors in Rat Pituitary Gland and Hypothalamus, J Neurochem 37:1546-1547.
• Kopin, I.J. (1985): Catecholamine Metabolism: Basic Aspects and Clinical Significance, Pharmacol Rev 37:333-364.[Medline] [Order article via Infotrieve]
• Kuzuya, H. (1978): Catecholamine Metabolism in Salivary Gland of the Rats. 5. Developmental Changes in Catecholamine, Normetanephrine and Metanephrine Contents, J Tohoku Dent Univ 5:36-40.
• MacLusky, N.J.; Barnea, E.R.; Clark, C.R.; and Naftolin, F. (1983): Catechol Estrogens and Estrogen Receptors. In: Catechol Estrogens, G.R. Merriam and M.B. Lipsett, Eds., New York: Raven Press, pp. 151-165.
• Martucci, C. and Fishman, J. (1976): Uterine Estrogen Receptor Binding of Catechol Estrogens and Estetrol (1,3,5,(10) estratriene-3,5,16,17-tetrol), Steroids 27:325-333.[CrossRef][Medline] [Order article via Infotrieve]
• Martucci, C.P. (1983): Metabolic Fate of Catechol Estrogens. In: Catechol Estrogens, G.R. Merriam and M.B. Lipsett, Eds., New York: Raven Press, pp.115-121.
• Merriam, G.R.; MacLusky, N.J.; Johnson, L.A.; and Naftolin, F. (1980a): 2-hydroxyestradiol-17 and 4-hydroxyestradiol-17, Catechol Estrogen Analogs with Reduced Estrogen Receptor Affinity, Steroids 36:13-20.[CrossRef][Medline] [Order article via Infotrieve]
• Merriam, G.R.; MacLusky, N.J.; Picard, M.K.; and Naftolin, F. (1980b): Comparative Properties of the Catechol Estrogens I: Methylation by Catechol-O-methyltransferase and Binding to Cytosol Estrogen Receptors, Steroids 31:1-11.
• Stefanini, M.; DE Martino, C.; and Zamboni, L. (1967): Fixation of Ejaculated Spermatozoa for Electron Microscopy, Nature 216:173-174.[CrossRef][Medline] [Order article via Infotrieve]

Journal of Dental Research, Vol. 66, No. 11, 1627-1629 (1987)
DOI: 10.1177/00220345870660110401


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Inoue, K. Articles by Creveling, C.R. Search for Related Content PubMed PubMed Citation Articles by Inoue, K. Articles by Creveling, C.R. Social Bookmarking                         What's this?