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Developmental Changes of Esteroprotease and Androgen Receptors in the Mouse Submandibular Gland

Department of Biochemistry, Iwate Medical University, School of Dentistry, Morioka, Iwate 020, Japan

R. Kurokawa

Department of Biochemistry, Iwate Medical University, School of Dentistry, Morioka, Iwate 020, Japan

M. Ota

Department of Biochemistry, Iwate Medical University, School of Dentistry, Morioka, Iwate 020, Japan

The activities of p-tosyl-L-arginine methyl ester (TAMEase) and cytosolic and nuclear androgen receptors in the submandibular glands of male and female mice were determined at various developmental stages. In males, the activity of TAMEase was detectable at four weeks after birth, and thereafter it increased rapidly. Cytosolic androgen receptor increased gradually with age, whereas nuclear androgen receptor, which was minimal one week after birth, increased remarkably four weeks after birth. In females, the minimal activity of TAMEase was detectable at five weeks after birth and increased very slowly with age. Cytosolic receptor increased with age, but nuclear receptor level was unchanged. These findings suggest that the appearance of TAMEase was in accordance with an elevation of nuclear androgen receptor in mice submandibular glands.

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Journal of Dental Research, Vol. 66, No. 11, 1623-1626 (1987)
DOI: 10.1177/00220345870660110301


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Baba, R. Articles by Ota, M. Search for Related Content PubMed PubMed Citation Articles by Baba, R. Articles by Ota, M. Social Bookmarking                         What's this?