Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Cutler, L.S.
Right arrow Articles by Mooradian, B.A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cutler, L.S.
Right arrow Articles by Mooradian, B.A.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Lumen Formation During Development of the Rat Submandibular Gland

L.S. Cutler

Department of Oral Diagnosis, University of Connecticut, School of Dental Medicine, Farmington, Connecticut 06032

B.A. Mooradian

Department of Oral Diagnosis, University of Connecticut, School of Dental Medicine, Farmington, Connecticut 06032

This study utilized electron microscopy and enzyme histochemistry to examine the morphological steps associated with the formation of a lumen in the end-buds of the embryonic rat submandibular gland. Lumen formation involved the development of junctional complexes by the central cells of the end-buds late on the 16th day of gestation. These junctional complexes established the apical domains of the presecretory cells, and cytofilament aggregates were observed beneath the presumptive luminal plasma membranes. This central area of the end-buds showed strong myosin ATPase activity, presumably associated with the cytofilaments. On the 17th day of gestation, small lumina appeared at the sites delineated by the junctional complexes. The myosin ATPase activity appeared to surround the newly opened lumina. By the 18th day of gestation, microvilli were seen projecting into the lumina, and secretory granules were often visible in the apical cytoplasm near the luminal plasma membranes of the early secretory cells. Myosin ATPase activity was greatly reduced once the lumina had formed.

REFERENCES

  • Cutler, L.S. (1973): Morphogenesis and Functional Differentiation of the Rat Submandibular Gland in vivo and in vitro: Ultrastructural and Biochemical Studies. Ph.D. Thesis, State University of New York at Buffalo, Buffalo, NY.
  • Cutler, L.S. (1977): Intercellular Contacts at the Epithelial-Mesenchymal Interface of the Developing Rat Submandibular Gland in vitro, J Embryol Exp Morphol 39:71-77.[Medline] [Order article via Infotrieve]
  • Cutler, L.S. (1980): The Dependent and Independent Relationships Between Cytodifferentiation and Morphogenesis in Developing Salivary Gland Secretory Cells, Anat Rec 196:341-347.[Medline] [Order article via Infotrieve]
  • Cutler, L.S. and Chaudhry, C.P. (1973): Intercellular Contacts at the Epithelial-Mesenchymal Interface During the Prenatal Development of the Rat Submandibular Gland, Dev Biol 33:229-240.[CrossRef][Medline] [Order article via Infotrieve]
  • Cutler, L.S. and Chaudhry, A.P. (1974): Cytodifferentiation of the Acinar Cells of the Rat Submandibular Gland, Am J Anat 143:201-218.
  • Cutler, L.S.; Christian, D.P.; and Bottaro, B. (1981): Development of Stimulus-Secretion Coupling in Salivary Glands. In: Methods in Cell Biology, Vol. 23. A.R. Hand and C. Oliver, Eds., New York: Academic Press, pp. 531-545.
  • Cutler, L.S.; Schneyer, C.; and Christian, C.P. (1985): The Influence of the Sympathetic Nervous System on the Development of β-adrenergic Receptors in the Rat Submandibular Salivary Gland, Arch Oral Biol 30:341-344.[CrossRef][Medline] [Order article via Infotrieve]
  • Guth, L. and Samaha, F.J. (1970): Procedure for the Histochemical Demonstration of Actinomyosin ATPase, Exp Neurol 28:365-367.[CrossRef][Medline] [Order article via Infotrieve]
  • Leblond, C.P. and Clermont, Y. (1960): The Cell Web, A Fibrillar Structure Found in a Variety of Cells and Animal Tissues, Anat Rec 136:230.
  • Madara, J.L.; Neutra, M.R.; and Trier, J.S. (1981): Junctional Complexes in Fetal Rat Small Intestine During Morphogenesis, Dev Biol 86:170-178.[CrossRef][Medline] [Order article via Infotrieve]
  • Mathan, M.; Moxey, P.C.; and Trier, J.S. (1976): Morphogenesis of Fetal Rat Duodenal Villi, Am J Anat 146:73-92.[CrossRef][Medline] [Order article via Infotrieve]
  • Pictet, R.L.; Clark, W.R.; Williams, R.H.; and Rutter, W.J. (1972): An Ultrastructural Analysis of the Developing Embryonic Pancreas, Dev Biol 29:436-467.[CrossRef][Medline] [Order article via Infotrieve]
  • Plasmeyer, J.H.J. (1969): The Action of Parathyroid Hormone on Salivary Glands in Culture. I. Some Aspects of the Organ Culture of Mouse and Rat Embryonic Salivary Glands with Special Reference to the Duct System, Proc Kon Ned Akad Wet C 73:75-92.
  • Redman, R.S. and Ball, W.D. (1978): Cytodifferentiation of the Secretory Cells of the Sublingual Gland of the Prenatal Rat: A Histochemical and Ultrastructural Study, Am J Anat 153:367-390.[CrossRef][Medline] [Order article via Infotrieve]
  • Redman, R.S. and Sreebny, L.M. (1970): The Prenatal Phase of Morphosis of the Rat Parotid Gland, Anat Rec 168:127-138.[Medline] [Order article via Infotrieve]
  • Shimono, M.; Nishihara, K.; and Yamamura, T. (1981): Intercellular Junctions in Developing Rat Submandibular Glands. (I) Tight Junctions, J Electron Microsc 30:29-45.[Abstract/Free Full Text]

Journal of Dental Research, Vol. 66, No. 10, 1559-1562 (1987)
DOI: 10.1177/00220345870660100901
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?



This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Cutler, L.S.
Right arrow Articles by Mooradian, B.A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cutler, L.S.
Right arrow Articles by Mooradian, B.A.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?