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Pharmacological of an Intra-oral Fluoride-releasing Device in Adolescents
K. Kula
Department of Pediatric Dentistry, University of Maryland at Baltimore. Baltimore, Maryland 21201
T. Kula
Department of Pathology, Medical Technology Program, University of Maryland at Baltimore. Baltimore, Maryland 21201
W. Davidson
Department of Orthodontics, University of Maryland at Baltimore. Baltimore, Maryland 21201
E. Parker
Department of Dental Hygiene, University of Maryland at Baltimore. Baltimore, Maryland 21201
The purpose of this study was to quantify fluoride (F) concentrations in body fluids of adolescents wearing two intra-oral fluoride-releasing devices (IFRDs) designed to release 0.10 mg Fiday. Fluoride concentrations were determined potentiometrically.
No significant increases occurred in urine or serum F concentratiotis during the 26-week device phase. Elevated salivary F concentrations were maintained throughout the device phase when broken or depleted IFRDs were replaced. However, salivary F concentrations returned to pre-device phase values, by 26 weeks when the original IFRDs were maintained. These findings suggest that IFRDs can significantly elevate salivary F concentrations of adolescents without significant elevations in systemic F concentrations.
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Journal of Dental Research, Vol. 66, No. 10,
1538-1542 (1987)
DOI: 10.1177/00220345870660100501
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