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Root Surface Caries and Periodontal Disease in Long-term Alloxan Diabetic Rats

Department of Oral Pathology, University of Umea

E. Haggz

Department of Medicine, University of UmeÅ. S-901 87 UmeÅ. Sweden

G.T. Gustafson

Department of Oral Pathology, University of Umea

Caries, periodontal disease, and occlusal wear were studied in rats with short-term (one month) and long-term (12 months) untreated alloxan diabetes and in age-matched control rats. Standard laboratory diet and water were given ad libitum. Streptococcus mutans and lactobacilli were naturally occurring inhabitants of the oral bacterial flora. In short-term diabetic rats, there was less dental plaque in the gingival region of the first mandibular molar than in control rats, but the density of leukocytes in the junctional epithelium was increased. Interdentally, the gingival papillae were intact, and the prevalence of foreign material was as low as for the controls. No caries lesions were seen. The proportion of the oral flora which was lactobacilli was positively correlated with the blood glucose level. In long-term diabetic rats, there was more periodontal breakdown than in the age-matched control rats. The periodontal breakdown was always associated with large interdental impactions of foreign material. Caries was seen only in the diabetic rats and in sites with interdental impactions. The decay was shown to start in the cementurn at the cemento-enamel junction. The amount of alveolar bone loss, but not the amount of dental caries, was related to the degree of hyperglycemia. Occlusal wear of the molars in long-term diabetic rats was significantly increased as compared with that in the controls.

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Journal of Dental Research, Vol. 65, No. 5, 689-694 (1986)
DOI: 10.1177/00220345860650051201


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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Reuterving, C.-O. Articles by Gustafson, G.T. Search for Related Content PubMed PubMed Citation Articles by Reuterving, C.-O. Articles by Gustafson, G.T. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Social Bookmarking                         What's this?